Dermatology exam part one

12/2013
1) The skin compartments, dermis& epidermis are:
a.
b.
c.
d.

Independent functionally.
Develop from the same origin.
Have little anatomical difference.
Inter dependent functionally.

ANS: D
2) Regarding cell differentiation the following factor affect its
sequence:
a.
b.
c.
d.
e.

Calcium concentration.
Protein kinas c.
Retinoic acid.
Expression of k1,k10
Interleukin 1.

ANS: C

3) Profilaggrin:
a.
b.
c.
d.
e.

A large calcium binding glycoprotein.

Expressed in chromosome 1q21.
High calcium concentration result in its assembly.
Synthesized in spinous layer.
Contain 15-20 repetition of filaggrin.

ANS:B

4) Filaggrin:

a. Cationic protein rich in histamine.

b. Is a molecule that organizes intermediate filaments
into macromolecules.
c. Disappear in the corneal layer.
ANS:B

5) The following cells are mesenchymal in origin:

a.
b.
c.
d.
e.

Melanocytes
Merkls cells.
Langerhans cells.
Stem cells.
Keratinocytes.

ANS: D?

6) periderm:
a. Highly differentiated cells.
b. Cells filled with glutamine.
c. It eventually shed out into the amniotic fluid as
development proceeds.
d. Its cells undergo apoptosis and disappear.
ANS: C

7) Spinous layer:
a.
b.
c.
d.

Found in the upper part of epidermis.

Have round cell nuclei.
Completely loses keratin 5 &14
Have fine and short keratin fibrils.

ANS: B

8) The skin layers in an embryo of 6 weeks:

a.
b.
c.
d.

Single layer of periderm.

Three layers.
Single layer of germenativum cell.
Two layers.

ANS:D

9) Which of the following regarding development is correct:

a.
b.
c.
d.

Desmosomal protein in 10 week.

Filaggrin in 12 wks.
Hair follicles in 15 wks.
Nail in 25 wks.

ANS:A

10) Which of the following is a component of sebum:

a.
b.
c.
d.

Phospholipids
Glycolipids.
Squalene.
Glycoprotein.

ANS:C

11) The antimicrobial effect of the skin can organized by:

a.
b.
c.
d.

Specific peptides.
Phospholipids.
Glycolipids.
Pyrolidon.

e. Carpoxyurocrnic acid.
ANS:A

12) In the Desmosomal junctions which of the following takes

part:
a.
b.
c.
d.
e.

Desmoglyins.
Desmocolins.
Desmoglyins & Desmocolins only.
Desmoplakins & desmoglyins.
Desmoglyins, Desmoplakins & Desmocolins.
ANS:E

13) In tight junction the following molecules are included:

a.
b.
c.
d.

Desmoglyins.
Catinins.
Claudins & ocludins
Connexons.

ANS: C

14) In alopecia areata the following feature is present:

a.
b.
c.
d.

Papules.
Itching
Exclamation mark hair.
Scales.

ANS: C

15) Regarding formation of corneal envelop:

a. Organized by single compartment.

b. Organized by two compartments.
c. Purely organized by lipid devoid protein
corneocytes.
d. Lipids have no role in envelop formation.
e. Organized by 3 compartments.
ANS: D

16) Langerhans cells are:

a.
b.
c.
d.

Round in shape.
Localized in spinous layer.
Are pigmented cells.
Have granulated cytoplasm.

ANS: D

17) Regarding pigmentary cells:

a. They travel to epidermis as
melanocytes.
b. Contain only one pigment.
c. Pigments are passed to other cells
in vesicular structure.
d. Pigments are passed to other cells
through MELANosmoses
ANS: A? MELANOBLASTS

18) SPRP:
a. Have 5 subtypes.
b. Cross link with involucrine.

c. Synthesis stimulated with ultraviolet

light.
d. SPRP3 is much expressed in vivo.
e. SPRP 2 is scanty in vivo.
ANS: C

19) Collagen:
a. Is formed of two chains.
b. Some are helical others are not.
c. Undergoes glycosylation before
expressed procollagen.
d. Collagen 4 has staggered
appearance.
ANS: C

20) Griseofulvin dosage is:

a.
b.
c.
d.
e.

2 mg /kg /day.
100/kg /day.
50/kg /day.
20/kg /day.
10/kg /day

ANS: E

21) The antilepromatous drug that has inflammatory action:

a.
b.
c.
d.
e.

Dapsone.
Rifampecine.
Corticosteroids.
Clofazimine.
Tetracycline.

ANS: A

22) In sever dehydration the following are characteristic

features except:
a.
b.
c.
d.
e.

Lethargy.
Sunken eyes.
Absent tears.
Eager to drink.
Depressed anterior fontanel.
ANS: D

23) In addition to water what are important components of

ORS (oral rehydration salt) was for rehydration:
a.
b.
c.
d.

Bicarbonate & potassium.

Chloride & potassium.
Sodium & glucose.
Sodium & lactate.

ANS: C

24) Neurosyphills:
a. Tabes dorsalis is a feature.
b. Appears after 6 month from
primary chancer.
c. Are reversible.
d. Abscess formation.
e. Organism can be isolated from
the lesion.
ANS: A

25) Chancroid has:

a.
b.
c.
d.

Clean shallow erosion.

Deep dirty ulcer.
Shallow ulcer.
Discrete enlarged lymph node.

ANS:C
26) Gonorrheal urethritis best treated by:
a.
b.
c.
d.
e.

Crystalline penicillin.
Procaine penicillin.
Tetracycline.
Erythromycin.
Ciprofloxacin.

ANS B
27) The main causative agent of non specific urethritis is:
a.
b.
c.
d.
e.

Mycoplasma spp.
Staphylococcus.
Streptococcus.
Chlamydia trachomatis.
Niseria gonorrhea.

ANS:D
28) Bullous impetigo is caused by:
a.
b.
c.
d.

Streptococcus.
Staphylococcus.
Mycobacterium
Chlamydia.

ANS:B
29) Pimphigus is skin condition:
a. Caused by microbial infection.
b. Malignant form

c. Auto immune disease.

ANS:C
30) The following are STD except:
a.
b.
c.
d.
e.

Scabies.
Molloscum contagiosum.
Syphilis.
Herpes simplex.
Gonorrhea.

ANS: B
31) The following are caused by dermatophytes except:
a.
b.
c.
d.
e.

Favus.
Kerion.
Piedra.
T.capitis.
T.corporis

ANS: C

32) Regarding spermatozoa:

a. Are motile in seminiferous
tubules.
b. Contain 46 chromosomes.
c. Contain enzymes in its head
aids in penetrating the ovum.
d. Stored in prostate.
ANS: C

33) Regarding dermis:

a. It is unlike epidermis doesnt

undergo sequential
differentiation.
b. Structure & organization are not
predictable.
c. Structure dont undergo
turnover in normal conditions.
d. Remodeling occur only under
pathological process.
ANS: A

34) In Non Hodgkins lymphoma the following are true

except:
a. Affect the lymph nodes.
b. Start in T cells.
c. Does not commonly extend to
other tissue.
d. The international WHO
classification is the latest
classification.
ANS: C

35) The following cause generalized hyper pigmentation:

a.
b.
c.
d.

Xeroderma pigmintosa.
Tattooing.
Addisons disease.
Crohns disease.

ANS:C

36) The following is best media to grow Chlamydia:

a. MC MOY cells.
b. Treated . MC MOY
cells.
c. Yolk sac of hen.
d. Chocolate agar.
e. Blood agar.
ANS: A OR B

37) The following is true about gonad tumors except:

a. Seminoma is the most common
type.
b. UN descended testis is prone to be
malignant.
c. Seminoma is radio resistant.
d. Presence of alfafeto protein.
ANS: A

38) In the stem cell cycle:

a.
b.
c.
d.

G1 is greatly variable in duration.

S phase takes from 4-6 hrs.
G0 is constant in the cycle.
G2 takes from 10-12 hrs.

ANS: A

39) In eccrine sweat gland:

a. The secretory part contain 2 layers
one clear cell secrete water &
electrolyte & other larger of dark
cells.

b. The intraepidermal part is known

as acrosyringium.
ANS:C

40) Concerning allergic dermatitis in children it start at the

age of:
a.
b.
c.
d.
e.

3 days.
3 months.
3 years.
5 years.
10 years.

ANS: C 3years in children , 3month in

infants

41) Multiple Myeloma all are true except:

a. There is a monoclonal raise in the
immunoglobulin electrophoresis.
b. IGA the highest immunoglobulin.
c. One of the most aggressive tumors.
ANS: B

42) The following are glycoproteins except:

a.
b.
c.
d.
e.
ANS: E

Laminin
Vitronictin.
Tinacin
Thrombospondin
Syndican.

43) The following are used in treatment of acne except:

a.
b.
c.
d.
e.

Dapsone.
Retinoic acid.
Anti androgens.
Steroids.
Tetracycline.

ANS: C?

44) The following is true about erector Pilli muscle:

a. Appear from the lateral wall to the hair
canal.
b. Aids in thermoregulation.
c. Contract in high temperature.
d. Connected to the basement membrane.
e. Support the sebaceous gland.
ANS: B

45) Apocrine gland:

a.
b.
c.
d.

Found in palms & soles.

The glands secreting milk is one of forms.
Develop in second month.
Sweat contains water, glucose &
electrolyte.

ANS: B

46) Regarding hair follicle:

a. Villous hair contains medulla.

b. Terminal hair grows vertically.

c. The order of layer from inside to out side
is (cortex ,medulla ,Huxley ,inner rout &
outer rout sheath)
d. The inner rout sheath melanocytes.
e. Differentiation & keratinization continue
till the end of hair shaft.
ANS: B

47) Proteoglycan & gags:

a. Have specific core protein in
proteoglycans.
b. Hold till 2000 of it weight water.
c. Are small molecules.
d. Consist 2% of the dermal molecules.
e. Are present in small amounts in the
dermis.
ANS: A

48) Epidermal barrier:

a.
b.
c.
d.

Is purely mechanical barrier.

Soluble substances penetrate easily.
Water is slightly permeable.
Highly permeable for covalent
substance.

ANS: D

49) Psorriasis is considered as systemic disease the most

common system involved with skin:

a.
b.
c.
d.
e.

Articular system.
Respiratory system.
GIT
Urinary system.
Nervous system.

ANS: E

50) Best treatment for tinia capitis is:

a.
b.
c.
d.
e.

Ketoconazole.
Topical antifungal.
Itraconazol.
Metronidazole.
Griseofulvin.

ANS: E

51) Which of the following is immune localized to basement

membrane:
a.
b.
c.
d.
e.

Entacitin.
Plectin.
Heparan.
Collagen 1.
Collagen 9.

ANS: C

52) Regarding papillary dermis:

a. Contain elunin elastic fibers.
b. Have large collagenous fibers.
c. Blood capillaries pass in couples to each
dermal papilla.
d.

e. Transfer cytokines & growth factors to the

epidermis.
ANS:E

53) Adherent junctions:

a.
b.
c.
d.

Connect neighboring cells.

Decrease in number with age.
Density is affected by the body site & sex.
Is the major type of junction in skin

ANS: A

54) The up words movement of differentiating cells from the

basal layer is depend on:
a. Crowding of the newly formed mitotic cells.
b. Damage of the desmosomes &
hemidesmosome.
c. Down regulation of 64 integrins.
d. Cytokines guard the movement.
e. Growth factors controls movement.
ANS: C

55) Subcutaneous tissue:

a.
b.
c.
d.
ANS: A

Is absents in & male genitalia.

Lipocytes develop in the 20th week.
Some premature as macrophage.
Adipocytes stores but not produce fats.

56) Brown fats:

a.
b.
c.
d.
e.

Mainly found in the retroperitoneal area.

Produce interleukin 1.
Are less active than white fat.
Is mono loculated.
Have no mitochondria.

ANS: A

57) Dermis:
a. Form 40% of bulk of skin.
b. Is completely tensile but restricted pliability.
c. Lymphocytes & plasma cells are not found
usually in normal skin.
d. Proteoglycans & gags are the only ground
substance.
ANS: D

58) The main lipid component in the corneal envelop is:

a.
b.
c.
d.
e.

Phospholipids.
Cholesterol.
Ceramides.
Triglycerides.
Free fatty acids.

ANS: C

59) In the DEJ which of the following is true:

a. Anchoring filaments connect the LD to the
upper dermis.

b. Laminin 5& 6 is the major component of

lamina Lucida.
c.
d.
ANS: B