Biology
Week 9
Inheritance...
How do cells
divide to
become
anything at
all?
Through a process
called Mitosis!
DIPLOID
Somatic cells are described as ................
(from the Greek meaning double).
you will see this written as 2n
Some cells in the human body are not diploid... Gametes contain only 1
copy of each gene as they have only 1 set of chromosomes.
Haploid
These cells are ..............
and are produced by a
Meiosis
special type of cell division called ............
zygote
This 1 cell
then divides
by
Mitosis
to produce
a complete
new
organism...
You received
one chromatid
from your
father.
And one from
chromatid your
mother!
GENE for
Eye colour
GENE for
Eye colour
Each chromosome
may have a
different version of
a gene.
GENE /
Allele for
Blue Eye
colour
GENE /
Allele for
Brown Eye
colour
Different versions of a
gene, that code for
different versions of a
characteristic, are called
ALLELES.
...Like Mendel, well start with the pea plants, which have easily
observable features that are controlled by a single gene.
T (TALL)
t (dwarf)
TT = homozygous dominant
(homo = same)
(so homozygous for T)
Tt = Heterozygous
(hetero = different)
tt = homozygous recessive
(homo = same)
(so homozygous for t)
T
t
Homozygous
Dwarf Plant (tt)
All gametes from the Tall plant contain a T allele, and all those from a
dwarf plant contain a t allele. These combine at fertilisation to give
offspring all with the genotype Tt (the genes / alleles that determine an
organisms phenotype)
However, although they look
identical in respect to their
Tall parent plant, they are
very different in one very
important respect: they are
Heterozygous and NOT
homozygous.
t
Heterozygous
(Tall) Plant (Tt)
25% = TT
50% =Tt
25% = tt
Heterozygous(Tall) Plant (Tt)
t
Heterozygous
(Tall) Plant (Tt)
Homozygous Recessive
Monohybrid
inheritance in
humans:
In contrast some
genetic disease, e.g.
Huntington's
disease, are caused
by DOMINANT
ALLELES.
Features
Dominant traits
Huntington's disease
Freckles
Freckles
Dimple in chin
Dimple in chin
Recessive traits
Albinism
Lactose intolerance
Cystic fibrosis
(B1 1.25 Symptoms of sickle cell disease and
cystic fibrosis)
Key
Hh
Affected male
hh
Unaffected male
Hh
Affected female
hh
Unaffected female
Father:
Mother:
Hh
hh
Genotype:
meiosis
h hH
hH
h
suffer
suffer
50% Chance
hh
h
hh
h
normal
normal
Key
hh S
R hh
hh
hh
hh
Hh
Affected male
hh
Unaffected male
Hh
Affected female
hh
Unaffected female
Heterozygous
Mother (Hh)
25% = HH
50% = Hh
25% = hh
3:1
Father:
Genotype:
Mother:
Ff
Ff
meiosis
Poss. Combinations of
Alleles
F
FF
fFf
F
Ff
fff
normal
carrier
carrier
suffer
Phenotype:
Heterozygous
Mother (Ff)
ff
FF
25% = FF
50% = Ff
25% = ff
3:1
B3 1.17
The sex of a person is
controlled by one pair of
chromosomes.
B3 1.18
How the sex of offspring is
determined at fertilization
(genetic diagram)
B3 1.17
The sex of a person is controlled by
one pair of chromosomes.
B3 1.18
How the sex of
offspring is determined
at fertilization (genetic
diagram)
Father:
Genotype:
Mother:
XX
XY
meiosis
Gametes
Poss. Combinations
Phenotype: i.e. Sex
XX
X
Y
XY
X
XX
XY
Y
Female
Male
Female
Male
Male = XY
X
X
Female =
XX
XX
50% = XX
50% = XY
1:1
Since the Y
chromosome is smaller
than the X chromosome
it carries fewer sexlinked genetic
disorders
So, colour
blindness, for
example is much
more common in
men than in women
because men only
require 1
(recessive) faulty
allele whereas
women need 2.
n
n
XX
This genotype is
rare
This genotype is
more common
n
XY
Parents Phenotype
Normal
Male:
Normal Female
(carrier)
Parents Genotype:
N
X Y
XN Xn
Genotype of Gametes
Poss. Combinations
Offspring's Phenotype: i.e. colour
blind / normal or carrier
meiosis
XN
Xn
XNXXNN
XN Y
Y
XXNNXn
XYnY
Normal
Female
Normal
Male
Normal
Female
Carrier
N
X
Colour
Blind
Male
Male = XNY
XN
XXN N
Female =
XNXn
XXnn
2:1:1
3:1
Homozygous:
Pair of alleles that produce a characteristic are the same, e.g.
Homozygous dominant = HH
Homozygous Recessive = hh
Heterozygous:
Pair of alleles that produce a characteristic; the alleles are different, e.g. Hh.
Dominant:
An allele that will always be expressed even when there is only one of these alleles present, represented by a capital letter. e.g.
HH or Hh. the H (dominate allele will be expressed)
Recessive:
An allele that will only be expressed when both alleles are of this type e.g. hh.
Gene:
Section of DNA that codes for a particular trait or characteristic.
Allele:
A different form of a gene that codes for a different version of a characteristic.
Genotype:
A description of the pair of alleles present for a characteristic.
Phenotype:
The physical expression of the alleles.