WHO nervous system tumors

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WHO classification of tumors of the nervous system

Tumors of neuroepithelial tissue
Astrocytic tumors
Pilocytic astrocytoma
Subependymal giant cell astrocytoma
Pleomorphic xanthoastrocytoma
Diffuse astrocytoma
Anaplastic astrocytoma
Glioblastoma
Gliomatosis cerebri
Oligodendroglial tumors
Oligodendroglioma
Anaplastic oligodendroglioma
Oligoastrocytic tumors
Oligoastrocytoma
Anaplastic oligoastrocytoma
Ependymal tumors
Subependymoma
Myxopapillary ependymoma
Ependymoma
Anaplastic ependymoma
Choroid plexus tumors
Choroid plexus papilloma
Atypical choroid plexus papilloma
Choroid plexus carcinoma
Other neuroepithelial tumors
Astroblastoma
Chordoid glioma of the third ventricle
Angiocentric glioma
Neuronal and mixed neuronal-glial tumors
Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos)
Desmoplastic infantile astrocytoma/ganglioglioma

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WHO nervous system tumors

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Dysembryoplastic neuroepithelial tumor

Gangliocytoma
Ganglioglioma
Anaplastic ganglioglioma
Central neurocytoma
Extraventricular neurocytoma
Cerebellar liponeurocytoma
Papillary glioneuronal tumor
Rosette-forming glioneuronal tumor of the fourth ventricle
Paraganglioma
Tumors of the pineal region
Pineocytoma
Pineal parenchymal tumor of intermediate differentiation
Pineoblastoma
Papillary tumor of the pineal region
Embryonal tumors
Medulloblastoma
CNS primitive neuroectodermal tumor (PNET)
Atypical teratoid/rhabdoid tumor

Tumors of cranial and paraspinal nerves

Schwannoma (neurilemoma, neurinoma)
Neurofibroma
Perineurioma
Malignant peripheral nerve sheath tumor

Tumors of the meninges

Tumors of meningothelial cells
Meningioma
Mesenchymal tumors
Adipose tissue: Lipoma, angiolipoma, hibernoma, liposarcoma
Fibrous tissue: Solitary fibrous tumor, fibrosarcoma, malignant fibrous histiocytoma
Smooth muscle: Leiomyoma, leiomyosarcoma
Skeletal muscle: Rhabdomyoma, rhabdomyosarcoma
Cartilage: Chondroma, chondrosarcoma
Bone: Osteoma, osteosarcoma, osteochondroma

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WHO nervous system tumors

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Vasculature: Hemangioma, epithelioid haemangioendothelioma, hemangiopericytoma,

anaplastic hemangiopericytoma, angiosarcoma, Kaposi sarcoma
Ewing sarcoma - PNET
Primary melanocytic lesions
Diffuse melanocytosis
Melanocytoma
Malignant melanoma, meningeal melanomatosis
Other neoplasms related to the meninges
Hemangioblastoma

Lymphomas and hematopoietic neoplasms

Malignant lymphomas
Plasmacytoma
Granulocytic sarcoma

Germ cell tumors

Germinoma
Embryonal carcinoma
Yolk sac tumor
Choriocarcinoma
Teratoma
Mixed germ cell tumor

Tumors of the sellar region

Craniopharyngioma
Granular cell tumor
Pituicytoma
Spindle cell oncocytoma of the adenohypophysis
Reproduced with permission from: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification
of Tumours of the Nervous System. IARC Press, Lyon 2007. Copyright 2007 IARC Press.
Graphic 73168 Version 13.0

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