MP
Nail Fungus Treatments
NUMBER 4
LE
VO L U M E 1 0
Resources:
Syed TA, Qureshi ZA, Ali SM et al.
Treatment of toenail onychomycosis
with 2% butenafine and 5% Malaleuca
alternifolia (tea tree) oil in cream. Trop
Med Intl Health 1999; 4: 284-287.
Case Report:
Terbinafine 1.67% Topical
Nail Solution for
Onychomycosis
SA
MyrtleTowne Pharmacy
Henderson Center Pharmacy
Eureka, California
1. [No author listed.] Drug Facts and Comparisons. St. Louis, MO: Facts and
Comparisons, Inc.; 2001.
Suggested reading
1. Buck DS, Nidorf DM, Addino JG. Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree)
oil and clotrimazole. J Fam Pract 1994; 38: 601-605.
2. Castle SS, Duncan MC, Allman JG. Onychomycosis therapy: Continuing
education. Americas Pharmacist 2001; July: 45-52.
MP
Tea tree oil is an essential volatile oil from the tea tree plant, Malaleuca alternifolia, said to have antiseptic properties. It is used for insect bites,
nail fungus infections, acne, vaginal fungal infections, as a deodorant, mouthwash, and a shampoo.
Read more about this essential volatile oil in this article:
Bottoni DJ. Tea Tree Oil. IJPC 1998; 2(4): 284-285.
Case Report:
Ketoconazole 2% and Ibuprofen 2% in Dimethyl
Sulfoxide, USP, Topical Nail Solution for
Onychomycosis
Barb Anliker, RPh
Kathy Jackson, Pharmacy Technician
into a stable solution, she prescribed a compounded nail solution containing ketoconazole 2% and ibuprofen 2% in dimethyl sulfoxide,
USP, 15 mL of which was dispensed in a brush applicator bottle of
the type that contains nail polish. The patient was instructed to use
the brush to apply the solution twice daily on top of and under each
affected toenail and to the surrounding tissue.
This patient was very compliant. After 6 weeks of the topical therapy
described, signs of improvement were evident; the nail had begun to
reattach to the nail bed. The patient was to continue that treatment
until each toenail had completely reattached to its nail bed.
References
LE
A 47-year-old white woman who loved to wear sandals had been embarrassed to do so for several years because her toenails had become
hard, yellow, and detached from the nail bed. Before coming to
our clinic, she had been diagnosed as having a bilateral fungal
infection (onychomycosis) of the great toenails and was treated
with terbinafine (Lamisil) and ketoconazole (Nizoral), both of
which were administered orally. Neither of these therapies was
effective in eliminating the infection. In December 2001, she
sought treatment from a member (PB) of the staff at the West
Bend Medical Clinic. The patient was treated with three 1-week
courses (pulse dosing) of itraconazole (Sporanox)1 (2 capsules
[100 mg per capsule] twice daily). Each week of therapy was
followed by a 3-week drug-free interval. At the conclusion of
that protocol, the patient was to return to the clinic for further
evaluation.
1. Olin BR, ed. Drug Facts and Comparisons. 56th ed. St. Louis, MO: Facts
and Comparisons 2002: 1448-1454.
2. Toney S, King E. Terbinafine 1.67% topical nail solution for onychomycosis. RxTriad 2001; November.
RxTriad-A publication of the International Journal of Pharmaceutical Compounding. 2007 IJPC. All rights reserved.