GENERAL AREAS OF INVESTIGATION

Adolescent Medicine

Acceptability of Vaccines by Teens and Parents (HPV vaccine) (Ryan and

Moriarty-Daley)
Acceptance and Provision of Primary Care Services through School-based clinic
settings (Moriarty-Daley)
Adolescent substance abuse and addiction (Smoking cessation, alternative
tobacco products, opioid addiction) (Camenga)
Eating disorders in adolescents (Ryan)
GYN issues in adolescents (Contraception, provision of GYN services in primary
care settings) (Moriarty-Daley)
Resident education in the use of SBIRT techniques (Screening and Brief
Intervention and Referral to Treatment) for substance use disorders (Ryan)
Technology based interventions to reduce substance use (Camenga)

Allergy and Immunology

Atopic dermatitis and the Atopic March (Zheng)

Autoimmune manifestations of Common Variable Immune Deficiency
(Romberg)
Characterization of molecular and cellular mechanisms in the pathogenesis of
atopic dermatitis (Translational research and genetically altered animal models
of atopic dermatitis) (Zheng)
Developing new therapeutics for allergic diseases, such as atopic dermatitis
and asthma (Zheng)
Function of glycoligand receptors in eosinophilic (Siglec-8) and neutrophilic
(Siglec-9) inflammation (Zhu)
Glycobiology of inflammatory lung diseases (Zhu)
Immune Deficiency in Autoimmunity (Price)
Molecular and cellular mechanisms of food allergy (Zhu)
Molecular mechanisms of primary immune deficiency diseases (Romberg)
Newborn screening for immune deficiency (Romberg)
Regulation of allergic and anaphylactic responses (Zhu)
Smith-Magenis Syndrome related immune deficiency (Romberg)

Cardiology

Follow up and midterm outcomes of new therapeutic catheterization

procedures; specifically transcatheter valve implantation for CHD (J Asnes)
Investigating the genetic causes and developmental mechanisms underlying
congenital heart defects (Brueckner)
Vascular-ventricular interaction and quantitative right ventricular function
assessment in congenital heart disease by echocardiography (Weismann)
Long term outcomes of adult patients with repaired or palliated congenital
heart disease who required surgery as children. In particular, he has focused
on the late term effects of the Fontan operation (used commonly as the last
stage of palliation for functionally single ventricle patients) and its complex
effects on the liver. He also has developed an interest in studying the effects
of immune dysfunction following early neonatal thymus removal in patients
who required sternotomy for repair of congenital heart disease as children.
(Elder)
Understanding pediatric heart disease and in particular heart failure and
cardiomyopathy. His research is primarily based upon modern approaches to
understanding these populations including mobile technology. (Hall)

Critical Care Medicine

Eedicine
A novel velocardiofacial malformation gene, mechanism discovery and novel
imaging mechanisms for discovery (Deniz)
Acute kidney injury in critically ill children (Couloures)
Acute lung injury (Giuliano)
Big Data and outcome measures (Panisello)
Big Data and Quality Improvement: How to improve the quality of medicine
using database analysis (Couloures)
Clinical trials in pediatric critical care including glucose control and Vitamin D in
critical illness (Kandil)
Gene discovery in patients with birth defects; developmental mechanism
discovery in the high-throughput model organism, Xenopus (Khokha)
Genetics of mammalian embryogenesis; neural development and patterning;
generation and analysis of animal models of genetic diseases/birth defects
(neurological, cystic kidney disease, heart malformations) (Liem)
Glucose control in critically ill patients (Faustino)
Pediatric septic shock (Giuliano)
Pediatric transport (Giuliano)
Quality improvement CLABSI VAP sepsis (Panisello)
Quality improvement including reducing non-planned extubations and
overall patient satisfaction (Kandil)
Quality improvement in reducing CLABSIs (Giuliano)
Venous thromboembolism (Faustino)
Developmental-Behavioral Pediatrics

Developmental screening in primary care (Weitzman)

Genetic basis of autism (Gupta)

Elucidation of neural systems in the pathophysiology of autism spectrum
disorders (Gupta)

Education

Faculty development (Hafler)

Interprofessional education (Colson)
Clinical research on infant mortality (Colson)

Emergency Medicine

Capnography (Langhan)
Clinical forensic medicine (Bechtel, Santucci)
Disaster preparedness (Cicero)
Global health (Arnold, Chen)
Infectious Disease (Aronson)
Information technology (Hsiao)
Injury prevention (Bechtel)
Language disparities (Riera)
Medical education (Arnold, Aronson)
Non-accidental injury (Bechtel, Tiyyagura)
Post-partum depression (Emerson)
Pre-hospital Care (Auerbach, Cicero)
Procedural readiness (Auerbach, Tiyyagura)
Quality and safety (Emerson, Santucci)
Resource utilization (Chen)
SANE: Sexual Assault Nurse Examiner (Bechtel)
Sepsis (Emerson)
Simulation (Auerbach)
Toxicology (Baum)
Trauma (Auerbach)
Ultrasound (Chen, Riera)

Endocrinology

Metabolic bone disease, Vitamin D, hypophosphatemic rickets (Carpenter)

Obesity/T2D: intensive life-style interventions, PK/PD studies of new drugs,
pathophysiology and insulin resistance, CNS control of appetite, fatty liver
disease, Pediatric Diabetes Consortium T2D Registry (Caprio, Jastreboff,
Santoro, Savoye, Van Name)
T1D: insulin pumps, continuous glucose monitoring, artificial pancreas
development, behavioral interventions to enhance metabolic control,
transitions in care, diabetes complications, metformin and other adjunctive
treatments, insulin pharmacokinetics and pharmacodynamics, T1D Exchange
Clinic Registry, cognitive and neural development in young patients, exercise
and glycemic control (Weinzimer, Cengiz, Sherr, Tamborlane and Van Name)

Gastroenterology & Hepatology

Clinical research in GI and inflammatory bowel disease (Pashankar)

Etiology and treatment of autoimmune hepatitis (Ekong)

Mechanisms of immune tolerance in liver transplantation (Ekong)
Role of CFTR in intestinal epithelium (Ameen)

General Pediatrics

Advisory Committee on Immunizations Practices (ACIP) (Vzquez)

Application of informatics in clinical care and optimizing use of guidelines in
clinical care (Shiffman)
Areas of research in well newborn care (Loyal)
Child abuse and child abuse prevention (Leventhal)
Critical Congenital Heart Disease screening in newborns (Loyal)
Effects of HIV disease on women and children. (Continued research in South
Africa includes clinical studies, intervention research addressing the
psychological effects of HIV on children and operations research focused on
improving programs for prevention of mother to child transmission.) (Forsyth)
Effectiveness of vaccines (Shapiro)
Enhancing recognition and reporting of child abuse in frontline medical settings
Evaluating the effectiveness of pediatric vaccines--varicella vaccine, Rotavirus
vaccines, Lyme vaccine, Pneumococcal conjugate vaccine, and Influenza
vaccine, among others. (Vzquez)
Group well child care (Fenick)
Integrative Medicine approach to children with chronic, unexplained pain
syndromes. (McCarthy)
Integrative pediatrics and outcomes research to advance the science and
clinical practice of pediatric integrative medicine by supporting a pilot program
at a highly esteemed academic medical center, providing data into
sustainability, feasibility, outcomes, and the potential for expansion to a larger
program. (Ali)
Irritable bowel syndrome and food hypersensitivity: Assessing inflammatory
cellular pathways (Ali)
Improving health care through community outreach (Rosenthal)
Improving identification of modifiable risk factors for child maltreatment in
primary care settings (A Asnes)
Lyme Disease (Shapiro)
Medical education innovations leading to improved patient care (Colson)
Medical education - curricula (Fenick)
Medically unexplained symptoms in children (Shapiro)
Motivational interviewing in obesity (Fenick)
Multicenter study being conducted in Argentina, India, South Africa and Turkey
to develop, validate and implement a method of assessing and monitoring
child development in resource-poor countries (Forsyth)
Prevention and epidemiology related to infant mortality (Colson)
Qualitative research & mixed methods studies (Colson)
Quality improvement (Osborn)
Quality improvement in primary care (Fenick)
Scholarship of education (J Hafler)
Screening for psychosocial stressors in primary care settings (A Asnes)
Studies focus on the assessment of the effectiveness of vaccines. (Vzquez)
Use of simulation as an educational tool in the newborn nursery (Loyal)

Vitamin K refusal in the newborn nursery (Loyal)

Yale Pediatrics-Dominican Republic Hospital Infantil Robert Reid Cabral (HIRRC)
collaboration. This new initiative is a multifaceted collaborative program
between Yale Pediatrics and the only public children's hospital in Santo
Domingo-- HIRRC. The collaborative program encompasses research initiatives
in the Dominican Republic, a bidirectional resident exchange program, and
faculty exchange (Vzquez)
Hematology/Oncology

Adolescent young adult oncology (Marks)

Bone marrow transplant (Kent)
Brain tumors (Marks)
Cancer survivorship (Kadan-Lottick)
Coagulation (Pels)
Disordered hematopoiesis (Kupfer)
DNA repair (Kupfer)
ITP (Dhodapkar)
Red cell development (Hattangadi)
Sickle cell anemia (F. Pashankar)
Solid tumors (F. Pashankar)
Tumor vaccine (Dhodapkar)

Care of the medically complex child (Nozetz)

Medical ethics with a focus on adolescent autonomy and medical education

(Hersh)

Political advocacy in pediatrics (Nozetz)

Development and utilization of metrics to improve quality and safety of health

care (Grossman, Osborn)

Hospital Medicine

Care of the medically complex child (Nozetz)

Medical ethics with a focus on adolescent autonomy and medical education

(Hersh)

Political advocacy in pediatrics (Nozetz)

Development and utilization of metrics to improve quality and safety of health

care (Grossman, Osborn)

Family-centered care (Berkwitt)

Neonatal abstinence syndrome (Grossman)

Development and utilization of metrics to improve quality and safety of
healthcare (Grossman, Osborn)
Medical ethics with a focus on adolescent autonomy and medical education
(Hersh)

Infectious Diseases

Biomarkers for monitoring antiretroviral therapy in resource-limited settings

(Paintsil)
Childhood Tuberculosis (Baltimore
Clinical and virologic factors contributing to long-term trends in morbidity and
mortality in perinatally-infected HIV+ adolescents and young adults. (Andiman)
Clinical Trial of investigational Staph aureus vaccine
Effectiveness of Rotavirus in children in the Dominical Republic
Effectiveness of vaccines in clinical practice (Shapiro)
Elimination of mother-to-child transmission of HIV (Paintsil)
Endocarditis (Baltimore)
Gastroenteritis in Latin America
Global health, including parasitic diseases (malaria, hookworm) in Africa and
Latin America (Cappello)
Host determinants of response to antiretroviral therapy (Paintsil)
Human Cancer Viruses The Miller laboratory studies the switch between
latency and lytic cycle of two oncogenic human herpesviruses, Epstein-Barr
virus (EBV) and Kaposis sarcoma associated herpesvirus (KSHV) (Miller)
Increasing uptake of HPV vaccine (Hansen)
Lyme Disease: Diagnosis, treatment, prevention and outcomes (Shapiro)
Pediatric nosocomial infections (Baltimore)
Resilience in long-term survivors of perinatally-acquired HIV infection:
Qualitative analyses of factors contributing to successful adolescent HIV care
(Andiman)
Text messaging as a platform to foster communication and well-being between
HIV+ adolescents and young adults and their health care providers (Andiman)

Neonatal-Perinatal Medicine

Bioethics (Mercurio)
Biological underpinnings of dyslexia (Gruen)
Bronchopulmonary Dysplasia (V Bhandari)
Case control study evaluating risk factors for tracheostomy in preterm infants
(Levit)
Comparing short and long-term outcomes following complicated endotracheal
intubation (Johnston)
Cytokines (V Bhandari)
Developmental follow-up of high risk infants (Ehrenkranz)
Dyslexia (Gruen)
Elliptocytosis; Pyropoikilocytosis (Gallagher)

Erythropoiesis (Gallagher)
Evaluating video laryngoscopy as a tool to teach endotracheal intubation
(Johnston)
Genetics of communication disorders and learning disabilities (Gruen)
Hereditary spherocytosis (Gallagher)
Hospital acquired infections (Bizzarro)
Hyperoxia-induced lung injury (V Bhandari)
Inherited abnormalities of the erythrocyte including metabolic, membrane, and
hemoglobin disorders lung development (V Bhandari)
Language impairment, learning disabilities, communication disorders (Gruen)
Neonatal infectious disease epidemiology (Bizzarro)
Neurology MRIs (Kwon)
Nitric oxide (V Bhandari)
Nutritional needs of extremely preterm infants (Ehrenkranz)
Neonatal hematology (Gallagher)
Possible emotional components of ethical decision making in clinical medicine
(Mercurio)
Sickle cell disease (Gallagher)
Stomatocytosis (Gallagher)

Nephrology

Cystatin C sodium kinetics in chronic hemodialysis (Marsenic-Couloures)

Identification of novel genetic causes of atypical HUD (Tufro)
Idenftification of novel genetic causes of nephrotic syndrome and FSGS (Tufro)
Post-translational modification of extracellular matrix proteins in diabetic
nephropathy (Tufro)
Role of the endothelial glucocorticoid receptor in hypertension, sepsis and
vascular disease (Goodwin)
Role of the podocyte glucocorticoid receptor in nephrotic syndrome (Goodwin)
Semaphorin3A and molecular mechanisms of diabetic nephropathy (Tufro)
VEGF and semaphoring functions on kidney development (Tufro)

Neurology

Alterations in functional organization of developing brain: Resting state

functional connectivity studies of extremely preterm neonates and gestationalage matched typically developing fetuses (Ment)
Bioethics including foregoing life sustaining treatment, requests for
inappropriate treatment, extreme prematurity (Miller)
Functional and micro structural investigations of pediatric stroke (Beslow)
Longitudinal studies of dyslexia: functional imaging, outcome and treatment
strategies (B Shaywitz and S Shaywitz)
Movement and paroxysmal disorders (Bamford)
Neurogenetic studies (Graf)
Pediatric MS and white matter disorders (Makhani)
Pediatric neuroethics including brain death, disorders of consciousness,
disorders of self, cognitive and moral enhancement (Miller)

Synaptic plasticity in Parkinsons disease, Huntingtons disease, and substance

dependence (Bamford)

Respiratory Medicine

Cystic fibrosis translational research studies (strategies to bypass the basic

defect) (Egan)
Dissecting the its role in the various cell types (epithelial, endothelial,
mesenchymal) (Esquibies)
Understanding the role of VEGF in embryonic lung /airway development
(Esquibies)
Factors that affect sleep quality in disease (neuromuscular disease, obesity
related lung disease) (Canapari, Gill)
How CFTR affects innate immunity and how this impacts the progression of CF
lung disease (Bruscia)
Impact of asthma on athletes (Weiss)
Mechanism for exercise-induced asthma (Weiss)
Obstructive sleep apnea (Canapari, Gill)
Regulation of ion transport across the airway epithelia in health and disease
(Egan)
Role of function of the cystic fibrosis transmembrane conductance regulator
(CFTR), a multifunctional protein encoded by the gene that is affected in cystic
fibrosis (CF) in abnormal ion transport in affected organs (Egan)
Role of SNPs in the vitamin D metabolism pathway on risk for developing
asthma (Bazzy-Asaad)
The impact of different routes of mesenchymal stem cell administration on lung
injury in a model of neonatal lung injury (Bazzy-Asaad in collaboration with Dr.
Laura Niklasson)
Understanding the molecular mechanisms by which the carotid body senses
change in pO2 (Donnelly)