Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Table of Contents
INTRODUCTION
AIM
GUIDELINE DEVELOPMENT PROCESS
CONSULTATION PROCESS
USE OF GUIDELINES
REVIEW PROCESS
TASK FORCE MEMBERS
3
3
3
4
4
5
1
2
3
SCOPE
EVIDENCE BASED RECOMMENDATIONS
SUMMARY OF RECOMMENDATIONS
7
7
10
11
1
2
3
11
11
14
SCOPE
EVIDENCE BASED RECOMMENDATIONS
SUMMARY OF RECOMMENDATIONS
15
1
2
3
15
15
17
SCOPE
EVIDENCE BASED RECOMMENDATIONS
SUMMARY OF RECOMMENDATIONS
18
1
2
3
18
18
21
SCOPE
EVIDENCE BASED RECOMMENDATIONS
SUMMARY OF RECOMMENDATIONS
REFERENCES
22
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Introduction
Aim
A working party of Dietitians from Australia and New Zealand has developed evidence based practice guidelines for the
dietetic management of chronic kidney disease. The purpose of these guidelines is to provide dietitians in Australia and
New Zealand with a user-friendly summary of evidence based clinical guidelines related to the dietetic management of
adult patients with chronic kidney disease.
Guideline Development Process
The evidence based practice guidelines for the dietetic management of chronic kidney disease were developed by
summarising the nutrition components of the following published guidelines:
Caring for Australians with Renal Impairment (CARI) Guidelines
Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines
American Dietetic Association (ADA) Medical Nutrition Therapy Evidence-Based Guides for Practice:
Chronic Kidney Disease (non-dialysis) Medical Nutrition Therapy Protocol
ADA Guidelines for Nutritional Care of Renal Patients (3rd ed)
European Dialysis and Transplant Nurses Association and European Renal Care Association (EDTNA/ERCA)
Guidelines for the Nutritional Care of Adult Renal Patients.
Levels of evidence or opinion have been cited from the above documents and referenced in each guideline. Descriptions
of the levels of evidence are listed in Appendix 3. The relevant guidelines and articles were identified by Medline
database and Internet key word searches between April 2002 and October 2003.
Where conflicting guidelines answering the same clinical question existed, the guideline with the strongest level of
evidence was included. When conflicting supporting evidence was equal in quality and depth, CARI guidelines were
selected preferentially as more relevant to the local environment. If similar information was proposed from more than
one set of guidelines, all sources were acknowledged. Aspects of nutritional management not included in any of the
guidelines were omitted, however some aspects deemed important by the taskforce have been included as practice tips.
Due to the difficulties associated with research into nutritional management of kidney disease, an evidence-based
approach could not be adopted for all aspects. For published guidelines based on opinion or agreed best practice without
supporting research, recommendations have still been included to complete the document but are acknowledged as
being open for wider variance in practice. In particular, adherence to process type guidelines may be strictly resource
dependant.
The selected guidelines were reformatted into the following components: definition of disease, diagnostic criteria,
clinical questions to be addressed, referral criteria, nutrition assessment, nutrition prescription and outcome measures, in
line with established nutritional management process. Dietetic management of acute renal failure, transplantation,
nephrotic syndrome or kidney disease in paediatrics is not included.
These guidelines include information taken from existing sets of guidelines based on scientific evidence, and where no
evidence exists, published guidelines stating consensus opinion from experienced practitioners including dietitians have
been included. These guidelines do not address many issues concerning the implementation of dietetic practice, such as
using groups or individual consultations, educational strategies or counselling techniques. This is beyond the scope of
these guidelines and neither the evidence nor consensus opinion currently exists to promote one form of practice over
another.
The practice tips sections were added to provide further assistance to Dietitians and go beyond the scope of the
guidelines themselves. These sections are not evidence based but are included as a guide only, and are intended to
provide extra information about patient management.
These guidelines have been developed as a quality activity without funding, therefore there is no external influence on
the content of the guidelines. No member of the guideline taskforce has any conflict of interest to declare relating to the
development of these guidelines.
Consultation Process
These practice guidelines have undergone several stages of peer and expert review using the Appraisal of Guidelines for
Research and Evaluation (AGREE) instrument (The AGREE Collaboration). The rigour of scientific process varies
between guidelines. The K/DOQI and CARI guidelines have documented systematic search and review processes in
place, which meet the NH&MRC and AGREE criteria for quality. The ADA and EDTNA/ERCA guidelines are less
rigorous, but the information extracted from these documents is based on expert opinion and is unable to be assessed
using an evidence based practice tool.
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
The first draft of these guidelines was presented at the Dietitians Association of Australia (DAA) 21st National
Conference in Cairns in May 2003 and achieved support in principle. A national panel of experts was defined at the
conference, the Australia and New Zealand Renal Guidelines Taskforce (ANZRGT) to oversee further development and
formulation of the final document. Consultation with nephrologists and renal nurses was undertaken when the
guidelines were presented at the 31st Annual Renal Society of Australasia Conference in Brisbane, also in May 2003.
The second draft was reviewed by the ANZRGT in August 2003 with comments incorporated into the final document.
ANZRGT launched the guidelines in Queensland on October 30, 2003 with the assistance of the Queensland Health
Core Practice Group. Following the launch of the 2003 Guidelines, a workshop was conducted at the DAA 22nd
National Conference in Melbourne in May 2004, on implementing the guidelines, and the taskforce gathered feedback
from the 6 month pilot period since launching the guidelines. Currently, the guidelines are published on the Queensland
Health Electronic Publishing Service (QHEPS) Internet site and are undergoing the endorsement process by DAA..
As part of the DAA endorsement process, consumer input was sourced from Kidney Health Australias regional
Advocacy Committees, which are comprised of CKD patients. A standardised feedback form was developed based on
recommendations from the Charter of Patient Rights. Feedback from consultation in two states has indicated that overall
consumers felt the guidelines provided a standardised approach to care, however were concerned that in their current
format were too technical to be understood by consumers. Consumers would have liked to have been involved from the
outset and were particularly interested that minority groups such as Indigenous people and those from non English
speaking backgrounds be considered in any educational material and that those in rural and remote areas receive the
same access to dietetic care as people in metropolitan areas. Discussion at both the National DAA workshops in 2003
and 2004 recognised the importance of involving consumers particularly from Indigenous backgrounds in the
development of education materials.
Use of Guidelines
These guidelines are meant to serve as a general framework for handling patients with particular health problems. It
may not always be appropriate to use these guidelines to manage clients because individual circumstances may vary.
The independent skill and judgement of the health care provider must always dictate treatment decisions. These
guidelines for practice are provided with the express understanding that they do not establish or specify particular
standards of care, whether legal, medical or other. (Adapted from Splett, 2000)
Review Process
These guidelines are based on other published guidelines and should be reviewed annually to ensure they remain
current. Responsibility for review lies with Royal Brisbane and Womens Hospital in conjunction with the Australia
and New Zealand Renal Guidelines Taskforce.
Next Review Date:
October 2005
References
The AGREE Collaboration. 2001. Appraisal of Guidelines for Research and Evaluation (AGREE) Instrument.
www.agreecollaboration.org (accessed 31/03/2003)
Splett, P.L. 2000. Developing and Validating Evidence Based Guides for Practice: A Tool Kit for Dietetics
Professionals, American Dietetic Association: United States of America.
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
POSITION
LOCATION
STATE
PHONE
Susan Ash
Associate Professor,
Dietitian
Renal Dietitian
Queeensland University of
Technology
Greenslopes Private Hospital
Qld
s.ash@qut.edu.au
Qld
trevorthomas@powerup.com.au
katrina_campbell@health.qld.gov.au
Kathryn Anderson
Katrina Campbell
RBWH
Qld
Maria Chan
Renal Dietitian
St George Hospital
NSW
Suzie Chesterfield
Renal Dietitian
RBWH
Qld
Chanm@sesahs.nsw.gov.au
(07) 3636 7997
suzie_chesterfield@health.qld.gov.au
Karen Corke
Renal Dietitian
Canberra Hospital
ACT
Karen.corke@act.gov.au
Ruth Dumont
Renal Dietitian
WA
Ruth.dumont@health.wa.gov.au
Kristin Gay
Renal Dietitian
Vic
k.gay@southernhealth.org.au
Lyn Lloyd
Renal Dietitian
NZ
64 9 5357 137
Lyn.lloyd@xtra.co.nz
Helen MacLaughlin
Renal Dietitian
Abbey Community
UK
helen.maclaughlin@abbeycommunity.org
Ellen McCoy
Renal Dietitian
RBWH
Qld
ellen_mccoy@health.qld.gov.au
Anthony Meade
Renal Dietitian
SA
Anthony.meade@nwahs.sa.gov.au
Robyn Montgomery
Renal Dietitian
Townsville Hospital
Qld
Tracey Tasker
Renal Dietitian
Tas
robyn.montgomeryjohnson@health.qld.gov.au
Tracey.tasker@dhhs.tas.gov.au
Paulett Thrift
Renal Dietitian
NSW
pthrift@doh.health.nsw.gov.au
Bernadeen Trotter
Renal Dietitian
NT
bernadeen.trotter@nt.gov.au
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Objectives
At what level of GFR should
patients be referred to the dietitian
in order to maximise nutritional
intervention opportunities?
Achieve and
maintain
desirable
weight and
adequate
nutritional
status
Nutrition Assessment
Which specific measures best
reflect nutritional status or change
in nutritional status in Chronic
Kidney Disease?
Optimise
status of comorbidities
Normalise or
stabilise
biochemical
markers
Nutrition
Prescription/Intervention
What is (are) the appropriate
nutritional intervention(s) to
optimise nutritional status in
Chronic Kidney Disease and
prevent malnutrition?
Maintain
skeletal
muscle stores
and strength
Patients to
achieve
individual
goals
Implementation and
Management
What is the optimal method of
implementation and follow up to
ensure nutritional status is
maintained or improved?
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Anthropometry
Measure
Outcome
Within the
population
normal
ranges
for
the
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Biochemistry
and Clinical
Measure
Outcome
>120mg/L (males)
>110mg/L (females)
<7%
Lifestyle
Measure
normalised
protein
nitrogen
appearance (nPNA) (3 evidence & opinion) if
available, Or
No level given
PRACTICE TIPS:
1. If you do use DEXA or BIA, ensure the patient is oedema-free prior to measurement or account for fluid
overload; see Appendix 9 for prediction equations.
2. Albumin: the presence of acute or chronic systemic inflammation limits the specificity of serum albumin as a
nutritional marker
3. GFR: see Appendix 5 for calculating GFR from serum creatinine
4. PTH: there is an inverse relationship between PTH levels and GFR, which is subsequently linked with lowturnover bone disease. This occurs in the absence of raised serum PO4 levels. Monitoring of PTH is
recommended at least every 12 months. (12)
5. Triglycerides recommend use normal acceptable levels, CKD is high risk category for heart disease
6. nPNA: see appendix 5 for calculating nPNA from 24hr urine collection. NB: nPNA related to protein intake
only when protein and KJ intake are constant and the patient is metabolically stable (2)
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
2.3
Energy
Ideal kilojoule/calorie energy intake determined for their age, gender, BMI and level of
physical activity
A nutritionally balanced diet with adequate energy intake to maintain a healthy weight
should be prescribed. (1 - level C evidence)
Protein
Fat and
Carbohydrate
Sodium
Potassium
Phosphate
Dietary phosphate restriction (800-1000 mg/d) and/or use of phosphate binders, if PO4
>1.49mmol/L (12 opinion) and/or PTH >7.7pmol/L on more than 2 consecutive
measurements (12 evidence).
Fluid
Intake should be adjusted to the degree of CKD, and prevention of renal disease, oedema
and hypertension management. Once fluid management requires diuretics a liberal fluid
intake should be curbed. Management of hypertension includes limiting fluid intake. (1
level C evidence)
Supplementation
Patients with chronic kidney disease with GFR < 50ml/min, and an elevated parathyroid
hormone (PTH) level or histological evidence of osteodystrophy, should receive
supplementation with vitamin D (calcitriol). (1 level A evidence)
Lifestyle
PRACTICE TIPS:
1. for IBW ranges see appendix 6
2. Energy: Weight loss is appropriate if BMI > 30 in order to manage co-morbidities (3 - opinion)
3. Protein: focus on achieving ideal intake and avoid the terms restriction or low protein
4. Fat: On occasions the fat intake may need to be increased to above 30% to prevent undesired weight loss.
Unsaturated fats are to be used in preference to saturated fat sources. (ANZRGT - opinion)
5. Potassium: A reduced potassium diet limits K+ intake to 1mmol/kg IBW/day. (ANZRGT opinion). Before
commencing this diet, ensure that hyperkalaemia is not a result of an acute response to conditions such as
uncorrected acidosis or raised haematocrit (ANZRGT opinion).
6. Phosphate: If PO4 >1.49mmol/L and/or PTH >7.7pmol/L, phosphate intake should be maintained between
<1000mg/day, in combination with use of PO4 binder medication (12 evidence and opinion). Care must be
taken when restricting PO4 intake, as to not compromise recommended protein intake (ANZRGT opinion).
7. The medical team should prescribe supplementation of vitamin D. The guideline on supplementation is
included for information purposes and the Dietitian may recommend supplementation.
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Management
6-12
monthly
For patients with GFR 30-60 ml/min (CKD stage 3) nutritional status
should be monitored every 6-12 months if there is no evidence of
malnutrition (3 opinion) and more frequently if malnourished
PRACTICE TIPS:
1. For patients with poorly controlled co-morbidities (hyperglycaemia, hypertension & hyperlipidaemia) refer to
the appropriate medical specialist for management of co-morbidities. (ANZRGT - opinion)
2. It is important to recognise this stage of CKD requires nutritional management to maximise health and
prevent nutritional deterioration. Individualised management with 6-12 monthly reviews is recommended. If
resources are not available to see patients, then documentation of referrals is advised, for future lobbying for
resources. (ANZRGT - opinion)
3. Consultation times account for patient contact time only and do not include additional time spent in associated
administrative tasks such as making patient-associated telephone calls, obtaining biochemistry results or
writing letters. (ANZRGT opinion)
3 Summary of Recommendations
-
10
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
2.2
Anthropometry
Biochemistry
and Clinical
Measure
Outcome
Within the
population
>120mg/L (males)
>110mg/L (females)
normal
ranges
for
the
11
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Measure
Biochemistry
and Clinical
(cont)
Outcome
<7%
Lifestyle
Measure
normalised
protein
nitrogen
appearance (nPNA) (2 evidence & opinion) if
available Or
No level given
PRACTICE TIPS:
1. If you do use DEXA or BIA, ensure the patient is oedema-free prior to measurement or account for fluid
overload; see Appendix 9 for prediction equations
2. Albumin: the presence of acute or chronic inflammation limits the specificity of serum albumin as a
nutritional marker
3. GFR: see Appendix 5 for calculating GFR from serum creatinine
4. PTH: there is an inverse relationship between PTH levels and GFR, which is subsequently linked with lowturnover bone disease. This occurs in the absence of raised PO4 levels. Monitoring of PTH is recommended
at least every 3 months. (12 opinion)
5. Triglycerides recommend use normal acceptable levels, CKD is high risk category for heart disease
6. nPNA: see appendix 5 for calculating nPNA from 24hr urine collection. NB: nPNA related to protein intake
only when protein and KJ intake are constant and the patient is metabolically stable (2)
12
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
2.3
Energy
Protein
For patients with progressive chronic kidney disease (GFR < 25ml/min), the protein
content of the diet should not be less than 0.75g/kg IBW/day. (1 - level A evidence)
At least 50% of the protein should be of high biological value. (1 - level A evidence)
Fat and
Carbohydrate
Sodium
Potassium
Phosphate
Dietary phosphate restriction (800-1000 mg/d) and/or use of phosphate binders, if PO4
>1.49mmol/L (12 opinion) and/or PTH > 12.1 pmol/L on more than 2 consecutive
measurements (12 evidence)
Fluid
Fluid intake should be adjusted to the degree of CKD, oedema and hypertension
management. Once fluid management requires diuretics a liberal fluid intake should be
curbed. Management of hypertension includes limiting fluid intake. (1 level C
evidence)
Supplementation
Patients with chronic kidney disease following a protein restricted diet (<0.75g/kg
IBW/day) should receive supplementation with thiamine (>1mg/day), B2 (1-2mg/day)
and B6 (1.5-2mg/day). (1 level B evidence)
Patients with chronic kidney disease with GFR < 50ml/min, and an elevated parathyroid
hormone (PTH) level or histological evidence of osteodystrophy, should receive
supplementation with vitamin D (calcitriol). (1 - level A evidence)
Lifestyle
PRACTICE TIPS:
1. for IBW ranges see appendix 6
2. Energy: maximise unsaturated fats and sugars or modular supplements to achieve energy intake of 125146kJ/kg IBW/day if in HWR. Weight loss is appropriate if BMI > 30 in order to manage co-morbidities (3 opinion).
3. Protein: The protein content should also not be greater than 1.0g/kg IBW/day. (ANZRGT opinion)
4. Fat: On occasions the fat intake may need to be increased to above 30% to prevent undesired weight loss.
Unsaturated fats are to be used in preference to saturated fat sources. (ANZRGT - opinion)
5. Potassium: A reduced potassium diet limits K+ intake to 1mmol/kg IBW/day. (ANZRGT opinion)
6. Phosphate: try to optimise compliance with PO4 binder medication in conjunction with maintaining phosphate
intake between 800mg and 1000mg/day, (12 evidence and opinion)
7. The medical team should prescribe supplementation of vitamins. The guidelines on supplementation are
included for information purposes and the Dietitian may recommend supplementation.
13
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Pre end stage kidney disease education forms an important part of the management
strategy to slow the progression of renal disease and may have an independent beneficial
effect. (1 level A evidence)
Nutrition counselling should encompass appropriate protein and energy intake (2
evidence and opinion), fluid, sodium and potassium intake (1 level C evidence), weight
management if indicated (1 & 3 - opinion), meal plans, recipe modification, self
monitoring and reading food labels (4 opinion).
Management
3 monthly
6-12 monthly
SGA (1 - opinion)
Assessment of long term nutritional adequacy with total body nitrogen,
DEXA or BIA (1 evidence and opinion) if available or appropriate
PRACTICE TIPS:
1. It is important to recognise this stage of CKD requires nutritional management to prevent malnutrition by
optimising protein, energy and fluid intake. Individualised management with 3 monthly reviews is
recommended. If resources are not available to see patients, then documentation of referrals is advised, for
future lobbying for resources. (ANZRGT - opinion)
2. For Patients with poorly controlled co-morbidities (hyperglycaemia, hypertension & hyperlipidaemia)
education should also address improving blood glucose control, weight management and blood lipids.
(ANZRGT - opinion)
3. Consultation times account for patient contact time only and do not include additional time spent in associated
administrative tasks such as making patient-associated telephone calls, obtaining biochemistry results or
writing letters (ANZRGT opinion)
3 Summary of Recommendations
-
14
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
For haemodialysis patients, nutritional status should be routinely assessed at commencement of haemodialysis
and at regular intervals thereafter. (1 evidence; 2 evidence)
PRACTICE TIP:
1. Prioritise those patients with poorly controlled co-morbidities or malnutrition. (ANZRGT - opinion)
2.2
Anthropometry
Biochemistry
and Clinical
Measure
Outcome
< 5.5mmol/L
TC<5.2mmol/L; LDL<2.6mmol/L; TG
<1.7mmol/L
15
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Biochemistry
and Clinical
(cont)
Measure
Outcome
<7%
Lifestyle
Energy
Protein
Fat and
Carbohydrate
Saturated fat <7%, poly-unsaturated fat 10%, mono-unsaturated fat 20% of total kJ
CHO 50-60% of total kJ (11 evidence and opinion)
16
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Sodium
Potassium
Phosphate
Dietary phosphate restriction (800-1000 mg/d) and/or use of phosphate binders, if PO4
>1.8mmol/L (12 opinion) and/or PTH >33.3pmol/L (12 evidence).
Fluid
500ml + previous days urine output (PDUO). (6 evidence and agreed best practice)
Supplementation
Lifestyle
PRACTICE TIPS:
1. Energy and Protein: IBW range for HD is BMI 22-25 (1 - opinion, ethnic group or age not specified), for
IBW ranges see Appendix 6; aim to achieve weight in IBW range
2. Phosphate: Care must be taken to make the diet as low as possible in phosphate whilst maintaining adequate
protein. To ensure a reasonable level, calculate 10-12mg phosphate per gram of recommended protein. (12
opinion).
3. Supplementation: The medical team manages prescription of vitamins and minerals. Supplementation as in
CKD stages 3 and 4 is still applicable. (ANZRGT - opinion)
4. Fibre intake should be encouraged, as constipation can be common in haemodialysis. (ANZRGT - opinion)
2.4
Education
Management
3 6 monthly
6-12 monthly
PRACTICE TIPS:
1. Consultation times account for patient contact time only and do not include additional time spent in associated
administrative tasks such as making patient-associated telephone calls, obtaining biochemistry results or
writing letters (ANZRGT opinion)
2. If resources are not available to see patients as frequently as recommended, then documentation is advised,
for future lobbying for resources. (ANZRGT - opinion)
3 Summary of Recommendations
-
17
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
For peritoneal dialysis patients, nutritional status should be routinely assessed at commencement of peritoneal
dialysis and at regular intervals thereafter. (1 & 2 evidence)
PRACTICE TIP:
1. Prioritise those patients with poorly controlled co-morbidities or malnutrition. (ANZRGT - opinion)
2.2
Anthropometry
Biochemistry
and Clinical
Measure
Outcome
Stabilise
If urea and /or creatinine are low patient
should be further evaluated for
malnutrition. (1 evidence)
Serum K
<7%
18
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Biochemistry
and Clinical
(cont)
Measure
Outcome
TC<5.2mmol/L; LDL<2.6mmol/L; TG
<1.7mmol/L
Lifestyle
PRACTICE TIPS:
1. nPNA: see appendix 5 for calculating nPNA from biochemistry. NB: nPNA related to protein intake only
when protein and KJ intake are constant and the patient is metabolically stable (2)
2. If you do use DEXA or BIA, ensure that measurement is performed at dry weight; see Appendix 9 for
prediction equations.
3. Albumin: the presence of acute or chronic inflammation limits the specificity of serum albumin as a
nutritional marker
4. Phosphate: < 30% of dialysis patients are able to maintain PO4 in the target range. The goal should be for
levels <2.2 mmol/L for lower risk of mortality. (12 evidence), and increase the percentage of patients in the
target range. (12 opinion).
5. Adequacy of dialysis can be assessed in several ways. The most common acceptable methods are: formal
urea-kinetic Kt/V, URR (urea reduction ratio), natural log Kt/V and the Daugirdas second generation formula.
A renal unit should be consistent in the method it applies. (1- Level C evidence)
4.3
Energy
19
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Protein
Fat and
Carbohydrate
Saturated fat <7%, poly-unsaturated fat 10%, mono-unsaturated fat 20% of total kJ
CHO 50-60% of total kJ (11 evidence and opinion)
Sodium
Potassium
Phosphate
Dietary phosphate restriction (800-1000 mg/d) and/or use of phosphate binders, if PO4
>1.8mmol/L (K/DOQI bone, opinion) and/or PTH >33.3pmol/L (12 evidence).
Fluid
Supplementation
Lifestyle
PRACTICE TIPS:
1. Energy & Protein: IBW range for PD is BMI 23-26 (opinion, ethnic group or age not specified), for IBW
ranges see Appendix 6; aim to achieve weight in IBW range
2. Energy: To calculate the energy from a peritoneal dialysis bag based on dextrose, estimate 60-100%
absorption of dextrose. For example for a 1500mL bag, 15% dextrose, will give 250-420kJ. Common
practise is to estimate absorption of up to 2000kJ/day from the diasylate, if a patient is on 4 bags per day.
(ANZRGT opinion).
3. Potassium: If restriction required, suggested level is 1mmol/kg IBW/day. (ANZRGT - opinion)
4. Phosphate: Care must be taken to make the diet as low as possible in phosphate whilst maintaining adequate
protein. To ensure a reasonable level, calculate 10-12mg phosphate per gram of recommended protein. (12
opinion).
5. Supplementation: The medical team manages prescription of vitamins and minerals. Multivitamin
supplementation may be required, and supplementation as in CKD stages 3 and 4 is still applicable.
(ANZRGT - opinion)
6. Encourage fibre intake. Constipation in PD can affect catheter position and increase risk of peritonitis.
(ANZRGT - opinion)
20
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Every peritoneal dialysis patient should receive intensive nutritional counselling based on
an individualised care plan (2 opinion) focusing on adequate protein intake and
appropriate energy intake (1 level C evidence), maintenance of muscle stores (1 level C
evidence), self monitoring and meal plans (8 no level cited).
Management
6 monthly
PRACTICE TIPS:
1. Consultation times account for patient contact time only and do not include additional time spent in associated
administrative tasks such as making patient-associated telephone calls, obtaining biochemistry results or
writing letters (ANZRGT opinion)
2. If resources are not available to see patients as frequently as recommended, then documentation is advised,
for future lobbying for resources. (ANZRGT - opinion)
3 Summary of Recommendations
-
21
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
References
1. The CARI Guidelines (Caring for Australians with Renal Impairment). 2003. Australian
Kidney Foundation & Australia New Zealand Society of Nephrology.
2. Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney
Foundation. 2000. American Journal of Kidney Diseases, 35 (supp 2), s1-s140.
3. National Kidney Foundation Kidney Disease Outcome Quality Initiative (K/DOQI) Advisory
Board. 2002. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation,
classification and stratification. American Journal of Kidney Diseases, 39 (supp 2), s1-s246.
4. American Dietetic Association. 2002. Medical Nutrition Therapy Evidence-Based Guides for
Practice: Chronic Kidney Disease (non-dialysis) Medical Nutrition Therapy Protocol.
Chicago: American Dietetic Association.
5. National Physical Activity Guidelines for Australians. 1999. Canberra: Australian Department
of Health and Ageing.
6. European Guidelines for the Nutritional Care of Adult Renal Patients. 2003. European
Dialysis and Transplantation Nurses Association/European Renal Care Association (EdtnaErca) Journal, 29(1), s1-s23.
7. Lowrie, EG & Lew, NL. 1990. Death risk in haemodialysis patients: the predictive value of
commonly measured variables and an evaluation of death rate differences between facilities.
American Journal of Kidney Diseases, 15, 458-482.
8. Wiggins, K.L. 2002. Guidelines for Nutritional Care of Renal Patients (3rd ed). Renal
Dietitians Dietetic Practice Group, American Dietetic Association. Chicago: American Dietetic
Association.
9. NKF-K/DOQI clinical practice guidelines for hemodialysis adequacy: update 2000. 2001.
American Journal of Kidney Diseases, 37 (supp 1), s7-s64.
10. NKF-K/DOQI clinical practice guidelines for peritoneal dialysis adequacy: update 2000. 2001.
American Journal of Kidney Diseases. 37 (supp 1), s65-s136.
11. K/DOQI Clinical Practice Guidelines for Managing Dyslipidemias in Chronic Kidney Disease.
2003. American Journal of Kidney Diseases, 41(supp 3), s1 s79.
12. K/DOQI Clinical Practice Guidelines for bone metabolism and disease in chronic kidney
disease. American Journal of Kidney Disease, 42(4), S7 S169.
22
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Chronic Kidney
Disease Stage 4
(GFR 15-29)3
GFR<30ml/min2
Chronic Kidney
Disease Stage 53
Haemodialysis
Upon commencement
Chronic Kidney
Disease Stage 53
Peritoneal Dialysis
Upon commencement
45-60 mins4
45-60 mins4
45-60 mins8
45-60 mins8
Nutrition
counselling
Review &
frequency of
follow up
Point of
referral
Time for
consultation
Biochemistry
and Clinical
Nutrition
assessment
References
The CARI Guidelines (Caring for Australians with Renal Impairment). 2003. Australian Kidney Foundation & Australia New Zealand Society
of Nephrology.
2.
Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. 2000. American Journal of Kidney
Diseases, 35 (supp 2), s1-s140.
3.
National Kidney Foundation Kidney Disease Outcome Quality Initiative (K/DOQI) Advisory Board. 2002. K/DOQI clinical practice guidelines
for chronic kidney disease: evaluation, classification and stratification. American Journal of Kidney Diseases, 39 (supp 2), s1-s246.
4.
American Dietetic Association. 2002. Medical Nutrition Therapy Evidence-Based Guides for Practice: Chronic Kidney Disease (nondialysis) Medical Nutrition Therapy Protocol. Chicago: American Dietetic Association.
5.
National Physical Activity Guidelines for Australians. 1999. Canberra: Australian Department of Health and Ageing.
6.
European Guidelines for the Nutritional Care of Adult Renal Patients. 2003. European Dialysis and Transplantation Nurses Association/
European Renal Care Association (Edtna/Erca) Journal, 29(1), s1-s23.
7.
Lowrie, EG & Lew, NL. 1990. Death risk in haemodialysis patients: the predictive value of commonly measured variables and an evaluation of
death rate differences between facilities. American Journal of Kidney Diseases, 15, 458-482.
8.
Wiggins, K.L. 2002. Guidelines for Nutritional Care of Renal Patients (3rd ed). Renal Dietitians Dietetic Practice Group, American Dietetic
Association. Chicago: American Dietetic Association.
9.
NKF-K/DOQI clinical practice guidelines for hemodialysis adequacy: update 2000. 2001. American Journal of Kidney Diseases, 37 (supp
1), s7-s64.
10. NKF-K/DOQI clinical practice guidelines for peritoneal dialysis adequacy: update 2000. 2001. American Journal of Kidney Diseases, 37
(supp 1), s65-s136.
11. K/DOQI Clinical Practice Guidelines for Managing Dyslipidemias in Chronic Kidney Disease. 2003. American Journal of Kidney Diseases,
41(supp 3), s1 s79.
12. K/DOQI Clinical Practice Guidelines for bone metabolism and disease in chronic kidney disease. American Journal of Kidney Disease, 42(4),
S7 S169.
1.
23
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
CKD Stage 4
GFR <30ml/min
CKD Stage 5
Haemodialysis
CKD Stage 5
Peritoneal Dialysis
Biochemistry
& Clinical
Energy
At least 146kJ/kg
IBW (BMI 18.5-25)
1
, 125-146kJ/kg IBW
>60 yr2
Protein
0.75-1.0g/kg
IBW/day1
0.75-1.0g/kg IBW1
with adequate kJ
intake1
>50% HBV1
Sodium
<100mmol if
hypertensive and
CKD is progressive1
<100mmol if
hypertensive and
CKD is progressive1
80 110 mmol/day6
Potassium
Not usually
restricted, If K+ > 6.0
limit intake1 to
1mmol/kg IBW/ day
If K+>6.0 limit
intake1 to 1mmol/ kg
IBW/day (ANZRGT)
1mmol/kg IBW/day8
146kJ (35kcal)/kg
IBW (BMI 22-25)1
inc glucose from
dialysate8
acute illness: >146
kJ/kg IBW /day2
min 1.2g/kg IBW1;
>50% HBV2
acute illness: >1.3g
/kgIBW2; peritonitis:
1.5g/kg IBW6
Indiv treatment
recommended, if
restricted 80-110
mmol/day6
Indiv treatment
recommended, if
restricted 1mmol/ kg
IBW/day (ANZRGT)
(ANZRGT)
Phosphate
Fluid
References
The CARI Guidelines (Caring for Australians with Renal Impairment). 2003. Australian Kidney Foundation & Australia New Zealand Society
of Nephrology.
2.
Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. 2000. American Journal of Kidney
Diseases, 35 (supp 2), s1-s140.
3.
National Kidney Foundation Kidney Disease Outcome Quality Initiative (K/DOQI) Advisory Board. 2002. K/DOQI clinical practice guidelines
for chronic kidney disease: evaluation, classification and stratification. American Journal of Kidney Diseases, 39 (supp 2), s1-s246.
4.
American Dietetic Association. 2002. Medical Nutrition Therapy Evidence-Based Guides for Practice: Chronic Kidney Disease (nondialysis) Medical Nutrition Therapy Protocol. Chicago: American Dietetic Association.
5.
National Physical Activity Guidelines for Australians. 1999. Canberra: Australian Department of Health and Ageing.
6.
European Guidelines for the Nutritional Care of Adult Renal Patients. 2003. European Dialysis and Transplantation Nurses Association/
European Renal Care Association (Edtna/Erca) Journal, 29(1), s1-s23.
7.
Lowrie, EG & Lew, NL. 1990. Death risk in haemodialysis patients: the predictive value of commonly measured variables and an evaluation of
death rate differences between facilities. American Journal of Kidney Diseases, 15, 458-482.
8.
Wiggins, K.L. 2002. Guidelines for Nutritional Care of Renal Patients (3rd ed). Renal Dietitians Dietetic Practice Group, American Dietetic
Association. Chicago: American Dietetic Association.
9.
NKF-K/DOQI clinical practice guidelines for hemodialysis adequacy: update 2000. 2001. American Journal of Kidney Diseases, 37 (supp
1), s7-s64.
10. NKF-K/DOQI clinical practice guidelines for peritoneal dialysis adequacy: update 2000. 2001. American Journal of Kidney Diseases, 37
(sup 1), s65-s136.
11. K/DOQI Clinical Practice Guidelines for Managing Dyslipidemias in Chronic Kidney Disease. 2003. American Journal of Kidney Diseases,
41 (supp 3), s1 s79.
12. K/DOQI Clinical Practice Guidelines for bone metabolism and disease in chronic kidney disease. American Journal of Kidney Disease, 42(4),
S7 S169.
1.
24
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Description
Grade I The evidence consists of results from studies of strong design
for answering the questions addressed. The results are both clinically
important and consistent with minor exceptions at most. The results
are free of serious doubts about generalisability, bias, and flaws in
research design. Studies with negative results have sufficiently large
samples to adequate statistical power.
Grade II The evidence consists of results from studies of strong
design for answering the questions addressed, but there is uncertainty
attached to the conclusion because of inconsistencies among the
results for different studies or because of doubts about
generalisability, bias, research design flaws or adequacy of sample
size. Alternatively, the evidence consists solely of studies from
weaker designs for the questions addressed, but the results have been
confirmed in separate studies and are consistent with minor
exceptions at most.
Grade III The evidence consists of results from limited studies of
weak design for answering the questions addressed. Evidence from
studies of strong design is either unavailable because no studies of
strong design have been done or because the studies that have been
done are inconclusive due to lack of generalisability, bias, design
flaws or inadequate sample sizes.
Grade IV The support of the conclusion consists solely of the
statements of informed medical commentators based on their clinical
experience, unsubstantiated by the results of any research studies.
Level A Randomised controlled trials and meta analyses
Level B Descriptive Studies
Level C Consensus or opinion
A rating of "evidence" was defined as "mainly convincing scientific
evidence, limited added opinion";
"Opinion" was defined as "mainly opinion, limited scientific
evidence";
"Evidence and Opinion" was defined as "about equal mixtures of
scientific evidence and opinion."
S Analysis of individual patient data from a single large, generalisable
study of high methodological quality (for example NHANES III)
C Compilation of original articles into evidence tables
R Review of reviews and selected original articles
O Opinion
No levels of evidence or opinion provided
Examination of the scientific literature shows a paucity of evidence
on dietary advice in renal failure. Therefore the guidelines are based
on scientific evidence, where available, and on a consensus of what
constitutes best practice where not.
25
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Appendix 5: Calculations
1. GFR
Cockcroft-Gralt Formula for estimating creatinine clearance / GFR
GFR (ml/min) = (140 - age in years) x weight in kg
814 x serum creatinine in mmol/L
Multiply by 0.85 for women
2.
BIA
Use Kushner formula for calculation of total body water (TBW)
Males:
TBW=8.399+0.396(H2/R) + (0.143W)
Females:
TBW=8.315+0.382(H2/R) +(0.105W)
R is resistance in ohms
H is the Height in cm
W is the weight in kg
Kushner, R.F. & Schoeller, D.A. 1986. Estimation of total body water by bioelectrical impedance analysis. Am J Clin Nutr 44:417-424.
DEXA
Use Lukaski formula for fat free mass (FFM) which is roughly equivalent to lean body mass (LBM)
FFM = -4.03+(0.734H2/R) +(0.116W) +(0.096Xc) +(0.878 x 1 for males or 0 for females)
Xc= compacitents
Lukaski, H. C., Bolonchuk, W. W., Hall, C. B. & Siders, W.A. 1986. Validation of tetrapolar bioelectrical impedance method to assess human body
composition. J Appl Physiol 60:1327-1332.
3.
Calculation of normalised protein nitrogen appearance (nPNA) (adapted from The CARI Guidelines)
26
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
significant difference to the measured protein intake. However, if dialysate protein loss is excessive (greater than 10-15
g protein per day), this needs to be additionally accounted for in making an estimate of protein intake [15 in 1]. In this
case it is recommended that the protein intake be determined from the UNA by determining the protein equivalent of
nonprotein nitrogen appearance (PNPNA), which in the individual patient, is equal to the PNA minus protein losses.
This should reflect the net protein intake under steady state conditions, i.e. the total intake of protein minus dialysate
and urinary protein losses [13 in 1]. Thus by determining the PNPNA (see below) and adding dialysate and urinary
protein loss, a more accurate estimate of the PNA may be made.
PNPNA (g/day) = 15.1+ 6.95 x UNA (g/24 hrs)
or
PNPNA(g/day)=15.1+0.195xUA (mmol/24 hrs)
The terminology is often loosely applied, so that the terms used in applying urea kinetic modelling to nutrition in CAPD
have recently been redefined [16 in 1]. For practical purposes the PNA can be substituted for the older terminology
referring to it as the protein catabolic rate or PCR. Studies assessing the benefits of the kinetically derived protein intake
suggest that relaying the information back to the patient results in an improved compliance with dietary
recommendations [17 in 1].
Haemodialysis
The methods used to determine the PNA differ in the HD and PD population, The most widely used method calculates
the urea generation rate from the end of the first dialysis to/the beginning of the second dialysis and relies
predominantly on the difference between the post and pre dialysis urea values .
Several methods are used to calculate the urea generation rate from which the PNA are calculated.
PNA = UGR (g/24 hrs) + 1.7 + Urinary protein losses
0.154
UGR
Note: In all cases urinary urea and protein losses need to be measured and included in the calculations used to
estimate protein intake.
27
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Pre-Dialysis
<18.5
20-25
25-30
>30
Dialysis (Haemodialysis,
Peritoneal Dialysis)
<18.5
23-26
26-32
>32
The Council for Renal Nutrition (American Kidney Foundation) recommend an ideal body weight of BMI 20-25 for
pre-dialysis patients and BMI 23-26 for dialysis patients. They do not address ethnicities or age groups in defining
these levels.
28
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
No
Unsure
Yes
see below
If yes, how much weight (kg) have you lost?
1.0 5.0
6.0 10.0
11.0 15.0
> 15.0
No
Yes
Total Score :
29
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Medical History
WEIGHT
Wt change past 6 months
0-<5% loss
5-10% loss
>10% loss
Usual weight.
Amount weight loss....
Current weight...
% weight loss.
*
*
*
Amount.
*
*
*
*
*
*
*
DIETARY INTAKE
No change; adequate
No change; inadequate
*
*
Duration of change...
Change
Suboptimal diet
Full liquid
Hypocaloric liquid
Starvation
*
*
*
*
*
*
*
*
*
*
GASTROINTESTINAL SYMPTOMS
Frequency (never, daily, no. of times/week)
Nausea
Vomiting
Diarrhoea
Anorexia
None; intermittent
Some (daily >2 week)
All (daily >2 week)
*
*
*
FUNCTIONAL
CAPACITY
No dysfunction
Difficulty with ambulation/normal activities
Bed/chair-ridden
Duration of change ..
*
*
*
*
*
*
30
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Physical examination
SUBCUTANEOUS FAT
Under the eyes
Triceps
Biceps
MUSCLE WASTING
Temple
Well-defined
muscle/flat
Not visible in Males;
may be visible but not
prominent in females
Rounded
Clavicle
Shoulder
Scapula/ribs
Calf
Knee
Quadriceps
Hollowed look,
depression, dark circles
Very little space
between fingers, or
fingers touch
Very little space
between fingers, or
fingers touch
Slight depression
Hollowing, depression
Protruding/prominent
bone
No square look;
acromion process may
protrude slightly
Mild depressions or
bone may show
slightly; not all areas
Mild depression
Muscle protrudes;
could be flat in females
No sign
Mild to moderate
Severe
No sign
Mild to moderate
Severe
Adapted from: Detsky et al., 19948; Baxter Healthcare Corporation, 1993; McCann, 1996
(Ferguson, Bauer, Banks, Capra, 1996)
31
Evidence Based Practice Guidelines for the Nutritional Management of Chronic Kidney Disease
Appendix 9: Glossary
Adult: any person over the age of 18
BIA: Bio-electrical impedance analysis is a method of measuring body composition based on the difference in
conductivity of body fat and fat-free tissue.
Body weight: use dry, oedema-free, post dialysis or non-dwelling body weight for all calculations
DEXA: Dual x-ray absorptiometry is a method of measuring body composition using x-ray technology.
Kt/V: Kt/V is a measure of dialysis adequacy. K is the urea clearance of the dialyser, t is the time between drawings of
blood (in minutes) and V is the patients total body water volume. Kt/V is regularly calculated for al dialysis patients.
This measure can be adversely affected by many patient related or dialysis associated variables.
nPNA: Normalised Protein equivalent of Total Nitrogen Appearance normalised to ideal body weight. See Appendix 6
to calculate nPNA.
Urea Reduction Ratio (URR): A method used to calculate adequacy of haemodialysis is the urea reduction ratio,
where adequate dialysis is a reduction of 65% or more between the pre and post dialysis serum urea values.
32