Numrul total de ore (pe semestru) din

planul de nvmnt
(36 hours semester I)

FIA DISCIPLINEI

Denumirea disciplinei
Anul de studiu

PHARMACOLOGY - ALGESIOLOGY
IV

Semester *

Type of final evaluation (E / V / C)

Regimul disciplinei (Ob obligatorie, Op opional, F - facultativ)

Total ore din planul de nvmnt
Titularul disciplinei

36

Number of hours for

individual study

V1

Ob

Numrul de credite

25

Total number of
hours

61

Prof. Ctlina Elena Lupuoru, MD, PhD

* Dac disciplina are mai multe semestre de studiu, se completeaz cte o fi pentru
fiecare semestru
Total
C**
S
Facultatea

Faculty of Medicine

Departamentul

Morpho-functional sciences

Profilul

Health

Specializarea

Medicine

36

18

18

** C curs, L activiti de laborator, P proiect

sau lucrri practice

Cunotine minime necesare studenilor pentru parcurgerea noiunilor de curs/stagii/lucrri

practice
physiology/patho-physiology, biochemistry, neuro-anatomy, medical and surgical semiology
Obiectivele disciplinei
1. study of main mechanism of drug action and of basic data on drugs pharmacokinetics in order to
understand the main indications, contraindications, adverse effects and interactions of drugs as options for
clinical drug therapy
2. study of drugs dosage forms
3. doses and units of measure used in pharmacology
4. study of general rules for writing prescriptions
5. differentiate between adverse effect, toxic effect, types of drug interactions
6. presentation of the importance of pharmacovigilence
7. study of general principles of treatment in various drug intoxications and non-drug intoxications
8. presentaton of particularities of main types of drug dependence
Programa analitic a cursului
Nr. ore
1. Drugs acting on central nervous system (CNS). Opioids. Cough suppressants and 2 hours
expectorants drugs.

2. Drugs acting on CNS. Anxiolytic sedative hypnotic drugs. Local and general
anesthetics.
3. Drugs acting on CNS. Antiseizure drugs.
4. Drugs acting on CNS. Antipsychotic agents. Antidepressant agents. Drugs of
abuse.
5. Skeletal muscle relaxants. Pharmacologic management of parkinsonism and
other movement disorders.
6. Nonsteroidal antiinflammatory drugs (NSAIDs). Analgesic antipyretic drugs
without anti-inflammatory effect. Disease-modifying antirheumatic drugs. Drugs
used in gout.
7. Pharmacology of endocrine system: drugs affecting hypothalamic and pituitary
gland hormones; drugs affecting adrenocortical hormones.
8. Pharmacology of endocrine system: drugs affecting thyroid hormones; agents
that influence bone mineral homeostasis; drugs affecting pancreatic hormones.
9. Pharmacology of endocrine system: Drugs affecting sex hormones analogues
and antagonists. Hormonal contraception.
Programa analitic lucrri practice/stagii
1. Dosage forms of drugs. Compounded and precompounded prescriptions
general rules. Adverse effects and toxic effecs of drugs. Compounded prescription:
sirop. Discussions from lectures.
2. Compounded prescription: package, cachets, enema, suppositories. Restricted
regimen prescriptions. Discussions from lectures: pharmacodynamic particularities
of opioids used in therapy. Acute intoxication with opioids. Addiction to opioids.
3. Precompounded prescription: tablets, capsules, dragees, sirop, solution for oral
administration, solution for parenteral administration. Acute intoxication and
addiction to benzodiazepine. Acute intoxication and addiction to barbiturates.
Discussions from lectures: particularities of administration of anxyolytic sedative
hypnotic drugs depending on associated diseases; adverse effects and interactions
of different types of anesthetics.
4. Compounded prescription: ointment, pessaries. Acute intoxication with
methanol. Acute and chronic intoxication with ethanol. Discussions from lectures:
pharmacokinetics and pharmacodynamic particularities of antiseizures drugs.
5. Compounded prescription: ointment, pessaries. Practical demonstrations: effects
of a substance on CNS (behavioral tests), hipnotic effect of a drug, anticonvulsivant
effect of a drug. Acute and chronic intoxication with ethanol. Discussions from
lectures: indications, adverse effects and interactions of different antipsychotic
drugs and of antidepressant drugs.
6. Precompounded prescription: powder for parenteral use. Discussions from
lectures: therapeutic implications of mechanisms of action of skeletal muscle
relaxants and of antiparkinsonian drugs.
7. Precompounded prescription: eye drops, nasal drops, ear drops, mouth washes,
suppositories. Discussions from lectures: parcitularities of administration of
NSAIDs. Acute intoxication with Acethylsalicilic acid. Acute intoxication with
Acetaminophen.

2 hours
2 hours
2 hours
2 hours
2 hours

2 hours
2 hours
2 hours

2 hours

2 hours

2 hours

2 hours

2 hours

2 hours

2 hours

8. Precompounded prescription: ointment, patch transdermic, trochists. Discussions 2 hours

from lectures: supraphysiological doses of corticosteroids indications,
contraindications, adverse effects.
9. Prescriptions: associations of drugs. Compounded and precompounded 2 hours
prescription - review. Discussions from lectures: pharmacological influence of
glucidic metabolism; adverse effects of oral contraceptives.
Competene practice dobndite la finalul anului/semestrului
1. knowledge of main mechanism of drug action
2. knowledge of basic data on drugs pharmacokinetics
3. knowledge of main indications, contraindications, adverse effects and interactions of drugs
4. knowledge of drugs dosage forms, doses and units of measure used in pharmacology,
5. to write prescriptions
6. to differentiate between adverse effect, toxic effect, types of drug interactions
7. knowledge of pharmacovigilence
8. knowledge on general principles of treatment in various drug intoxications and non-drug intoxications
9. knowledge about drug dependence.
La stabilirea notei finale se iau n considerare

Ponderea n notare exprimat n

procente
(Total = 100%)

- rspunsurile la examen / colocviu (evaluarea final):

- rspunsurile finale la lucrrile practice de laborator
- testarea periodic prin lucrri de control

100%

- activitile gen teme / referate / eseuri / traduceri /

proiecte etc.
- alte activiti (PRECIZAI) : colocviu
Descriei modalitatea practic de evaluare final E/V (de exemplu: lucrare scris (descriptiv i
/ sau test gril i / sau probleme etc.), examinare oral, colocviu individual ori n grup, proiect,
etc.)
Teste scrise semestriale, rspunsuri la lucrrile practice
Examen final: examen practic i test gril unic (60 ntrebri cu rspunsuri multiple)
Periodic assessments: evaluation of theoretical knowledge by MCQ tests and of practical
knowledge by writing prescriptions on problem based cases.
Estimai timpul total (ore pe semestru) al activitilor de studiu individual pretinse
studentului
(completai cu 0 activitile care nu sunt cerute)
3
1. Descifrarea i studiul notielor de curs
8. Pregtire prezentri orale

2. Studiu dup manual, suport de curs

9. Pregtire examinare final

3. Studiul bibliografiei minimale indicate

10. Consultaii

4. Documentare suplimentar n bibliotec

11. Documentare pe teren

12. Documentare pe Internet

13. Alte activiti ....

14. Alte activiti ....

5. Activitate specific de pregtire

SEMINAR i / sau LABORATOR
6. Realizare teme, referate, eseuri,
traduceri, etc.
7. Pregtire lucrri de control

TOTAL ore studiu individual (pe

semestru) = 25

Bibliografie obligatorie :
1. Goodman Gilman A. The Pharmacological Basis of Therapeutics, 9th edition, McGrawHill,
2005
2. Lupuoru Ctlina Elena, Cristina Mihaela Ghiciuc, Liliana Taru. (editors) New
pathophysiological challenges and pharmacological approaches. Ed. Junimea, 2009.
3. Lupuoru Ctlina Elena, Liliana Taru. (editors) Adverse effects of pharmcologic active
substances: from bench to bedside. Ed. Junimea, 2009.
4. Katzung B.G. Basic&Clinical Pharmacology. 8th edition, Lange Medical Book, 2001.
5. Rang & Dale's Pharmacology, 6th Edition, 2007

Bibliografie suplimentar pentru materia de curs i lucrri practice Farmacologie

1. Roach Sally. Pharmacology for health professionals, Lippincott Williams and Wilkins, 2005.

Data completrii:
2012

Semntura coordonatorului de activitate didactic

Prof. Dr. Ctlina Elena Lupuoru