By
Aditi Banerjee
Role of solvents
n
Effects on
human health
Damage to
respiratory system,
nervous system
Factors
Dose
Potency
Route of
exposure
Green solvents
Source
n Sustainability of source
n Atom efficiency
n Energy processes
n Toxicity of by-products
n Reusability
n Product separation process
Just because the solvent is non-toxic it does not
make the process green
n
Product
Solute
Environment
Application
Solvent
Solvent
Recycle
Energy and efficiency
important
Toxicity or
neutralisation
important
hazardous to the
environment
hazardous to use
Alternative solvents
No solvent solventless reactions
n Water
n Super critical fluids
n Ionic liquids
n
Solventless reactions
Simplest solution
n Fails on large scale Exothermic
reactions can be dangerous
n Problem in mixing especially in case of
solids
n Solvents still required for extraction,
separation and purification of products.
n
DISADVANTAGES
n
n
n
Supercritical Fluids
Substance at a temperature and pressure
above its critical point
n Diffuse through solids like a gas dissolve
materials like a liquid
n Suitable substitute for organic solvents
n Carbon dioxide and water are the most
commonly used
n
Solid
Supercritical Fluid
Liquid
Gas
Ionic liquids
n
BF 4 N
n
n
n
Me
Me
Z n 2 C l 5 -
N+
Me
OH
Expensive
Questionable toxicity
Diels-Alder reactions
isoprene
n
n
n
but-3-en-2-one
Alkylation reactions
Hydroformylation reactions
Friedel Crafts reactions
Naphthalene
n
n
n
Conclusion
No process is GREEN
n There cannot possibly be an ultimate
green solvent. Hence we need to consider
the overall impact of any process on the
environment.
n We need to tailor a solvent as per the
application keeping in mind the
sustainability.
n
References
www.rsc.org
n www.pharmainfo.com
n www.supercriticalfluids.com
n www.wikipedia.com
n www.chem.leeds.ac.uk
n
Role of solvents
n
Coatings:
Cleaning
Paints, adhesives
1. Solvent usually removed by evaporation after application
leaving coating behind
2. Coating removal
E.g. Dry cleaning extensive use of perchloroethylene,
suspected of being carcinogenic, which also contaminates
groundwater supplies.
Extraction
Endothermic
n
n
n
n
n
n
n
Just because the solvent is non-toxic it does not make the process
green. We also need to consider:
Energy (evaporation, pressurisation, stirring etc.)
Whether the solvent can be recycled and used again
Toxicity of any by-products that are formed
Atom efficiency of process
Product separation process that would be involved?
Solvent replacement
n
n
n
n
n
n
n
n
n
n
Rates of reaction
Chemo-, regio- and stereoselectivity
Outcome of reaction may not work at all, or may
do something totally different!
Uses of supercriticalCO2
n
n
n
n
n