BC
106
muL)
2751
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
Platelets
(103 /muL) An
00.1
16.10.7
--
--
60.2
16.80.5
--
--
01.4
14.01.8
48.35.8
72.1
20.9
29.0
--
--
01.5
13.81.8
48.87.1
71.8
20.3
28.3
--
--
--
--
40.0
--
--
--
--
6.8
4.3
1.3
0.48
0.49
0.05
--
--
--
52.0
--
--
--
--
8.9
5.9
2.1
0.31
0.29
0.02
--
402.5 16.81.9
--
2.512.5
1.4-7.0
--
-10.0
8.0-15.0
24-45
37-49
--
30-36
--
5.5-19.5
01.0
11.61.5
34.74.2
43.2
14.4
33.4
--
12.5
71.3
10.92.1
346
41.02.8
--
32.10.8
--
--
60.7
11.31.0
353
--
--
3.20.9 8.5+2.2
0.1-0.79
0.1-0.79
rare
175-500
0.02
0.800.34
0.00
--
BC
106
muL)
HGB
(g/dL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
0-8.0
8.0-14.0
26-42
37-54
--
26-36
--
.00
11.0
35.0
52.0
14.0
32.7
0.0
--
--
41.84.7
--
--
--
--
--
01.3
11.71.9
38.77.0
53.0
16.0
30.2
--
--
00.7
11.71.4
38.35.8
58.0
17.7
30.5
--
--
.10
15.4
48.0
78.6
24.9
31.3
0.6
7.5
4.7
1.5
0.45
0.82
0.08
240
5.5
14.3
42.5
77.5
26.6
33.2
0.7
10.4
7.2
2.0
0.52
0.82
0.01
225
3.7
14.5
39.0
103.0
38.5
37.2
3.2
7.5
4.8
1.7
0.23
0.83
0.00
132
--
15.81.3
47.13.4
--
--
--
1.0 0.6
0.00
--
50.4
15.60.9
--
10.12.3 6.7.2
0.00
26848
80.5
15.91.2
--
0.00
29958
60.6
10.51.7
--
0.00
343149
40.7
11.11.9
--
0.00
38886
5-8.5
12.0-18.0
37-55
60-72
--
31-37
--
5.5-16.9
3.012.0
1.0-4.9
0.1-1.40
0.10-1.49
--
175-500
15.0
45.0
70.0
22.8
34.0
0.8
11.5
7.0
2.8
0.75
0.55
0.00
350
6.8
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
4.0-12.0 1.5-5.0
8.0
2.2
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
3.0-7.5
0.1-1.50
0.1-1.50
rare
175-620
4.5
0.40
0.70
0.06
500
Platelets
(103 /muL) An
BC
106
muL)
HGB
(g/dL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
3.3
13.6
41.0
125.0
41.0
32.5
0.1
11.4
00.4
10.22.4
34.84.8
--
14.32.2
43.46.5
--
--
--
15.90.7
48.41.8
--
0.2
17.8
55.4
8.1
16.2
8.1
14.6
Neutro Lymph
(103 / (103
muL) /muL)
2.5
5.1
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
0.46
0.34
2.70
540
0.54
0.06
--
Platelets
(103 /muL) An
--
--
--
--
--
--
--
--
54.0
17.6
32.2
4.0
9.7
5.5
3.5
0.43
0.23
0.01
453
49.2
61.0
19.9
32.8
5.3
10.5
6.2
3.5
0.46
0.27
0.02
545
48.0
59.6
18.1
29.9
0.3
5.4
3.0
1.3
0.49
0.59
0.00
247
20.4
14.80.4
47.51.0 54.62.1 17.70.8 32.40.8 3.10.8 12.12.0 2.41.1 9.51.8 0.110.05 0.140.09 0.190.06
--
--
14.10.5
45.81.3
--
--
--
--
3.30.9
50.51 15.90.6
--
0.04
0.16
0.01
--
50.51 15.00.4
--
0.03
0.10
0.04
--
601.1
9.70.8
--
--
90.9
9.70.6
--
--
3.00
82.3
90.3
10.0
10.31.5
13.0
15.80.6
28.0
19.5
6.5
33.0
41.3
79.1
24.9
31.0
0.0
--
1.4
--
9.0
3.3
5.0
13.3
7.3
4.7
0.30
0.50
0.05
450
0.10.1
0.40.3
0.20.1
--
1.20
0.01
0.07
250
BC
106
muL)
10.4
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
Platelets
(103 /muL) An
--
34165
20.56 16.21.1
46.03.4
--
--
--
--
0.20
0.50
--
24249
10.5
18.01.0
50.53.3
--
--
--
--
0.20
0.20
--
23841
40.4
16.80.7
--
42842
70.3
16.80.6
--
44349
70.63
--
--
--
--
--
--
25864
40.54
--
--
--
--
--
--
26028
01.2
14.41.7
--
225
7.3
13.41.1
VPRC
(mL/dL)
13.8
38.0
51.9
18.6
35.3
0.0
11.0-19.0
32-52
36-50
--
31-38
--
--
--
43.0
--
--
--
--
19.3
13.9
2.5
0.77
5.2
13.7
40.5
77.8
28.4
34.0
1.6
9.4
7.9
0.9
--
--
48.0
--
--
--
--
21.1
17.5
1.6
-13.0
8.0
5.7
6.0-12.5 2.7-7.0
2.0
1.5-6.0
0.27
0.04
0.01
202
rare
90-350
0.77
0.77
--
0.28
0.24
0.05
175
0.91
0.70
0.00
--
0.10-1.00 0.10-1.00
51.0
15.11.4
--
15.10.9
48.42.7
--
--
31.2
--
--
--
--
27579
--
BC
106
muL)
HGB
(g/dL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
--
14.60.7
45.92.3
--
--
31.8
--
30.5
14.51.1
1144226
930.4 16.30.6
1044157
540.3 16.70.4
994155
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
--
--
--
Platelets
(103 /muL) An
--
.76
14.5
45.0
57.7
18.4
31.9
2.5
7.4
2.3
4.0
0.18
0.58
0.03
--
4.0
10.1
31.9
79.0
26.0
32.0
--
12.0
4.7
5.5
1.12
0.56
0.12
250
--
--
91.1
14.91.7
--
60.9
12.41.1
--
--
80.9
12.41.1
--
--
81.2
14.11.8
--
31.1
15.61.0
--
50.9
--
--
--
--
20.4
9.01.3
--
--
00.7
14.41.3
40.63.6 59.52.2 21.30.8 35.90.5 0.70.5 11.92.2 4.42.0 6.71.3 0.060.09 0.580.36 0.110.09
33467
00.6
9.41.2
28.83.7 77.26.5 25.51.9 32.71.2 17.54.8 13.06.2 5.22.8 6.92.3 0.080.10 0.080.08 0.020.04
593226
0-8.0
10.0-18.0
50.32 12.90.7
33-50
50-67
--
30-34
--
--
10.022.0
3.210.0
4.5-13.0
0.1-2.00
0.2-2.00
rare
200-500
0.00.0
27958
BC
106
muL)
60.30 12.30.8
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
--
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
0.00.0
Platelets
(103 /muL) An
34887
50.4
11.70.7
382
834
262
321
33473
70.3
12.60.9
402
805
262
321
333136
60.4
13.41.0
414
824
261
332
337117
40.6
14.51.3
--
0.00.0
272116
20.5
13.41.2
--
0.00.0
27373
70.6
12.51.5
39.75.0 86.08.2
0-6.40
9.7-14.2
34-43
62-74
18-22
28-32
0-1.5
0-4.80 10.4-12.9
34-38
83-90
25-33
29-36
0.2-1.5
--
86.67.5
--
--
--
35-47
74-82
19-26
28-32
0-1.4
90.5
13.62.1
0-7.00 10.3-15.5
10.6
12.31.1
0-6.30 12.5-15.3
42.13.2 76.06.5
41-51
66-78
--
-21-26
29.12.0 0.50.4
31-34
40.5
17.11.3
50.2
16.11.1
90.2
0.4-0.7
--
2.8-9.7
350133
30-70 *
36-52
0-10
0-5
0-2
266-320
4.0-12.0 50-68 *
25-37
4-12
0-3
0.00
155-286
--
--
--
--
23093
17-34
0-8
0-2
0-1
149-309
8.12.6
--
3.9-15.0 60-82 *
10.3.6
2-11
418115
72-83 *
290-430
12-22
3-5
0-2
0-2
29590
18035
13.40.3
19335
70.5
14.71.3
00.3
17.40.7
39976
00.5
16.61.4
51.04.0 73.03.5 24.01.4 33.01.1 2.61.1 13.03.2 5.63.0 6.91.8 0.400.18 0.130.18 0.080.12
40282
--
--
--
>
>
BC
106
muL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
--
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
Platelets
(103 /muL) An
20.3
12.90.9
40.81.8 59.85.3
32.01.4
--
--
80.7
13.51.7
--
--
70.4
12.11.0
363
621
--
8.12.7 3215 *
6815
--
--
--
--
20.1
--
33.40.6
--
--
--
--
--
--
--
40316
5-5.8
9.6-13.1
31-41
62-82
18-27
28-32
0.8-5.0
4-16
0-3
1-6
230-690
00.4
14.00.6
43.02.0 65.04.0 21.01.0 32.54.0 24.44.0 6.81.2 1.70.8 4.10.5 0.430.22 0.030.03 0.220.03
--
00.6
12.70.6
39.02.0 66.02.0 22.01.0 32.83.0 24.04.0 5.60.9 1.90.2 2.70.8 0.360.11 0.070.04 0.260.11
--
.00
12.6
41.5
60.0
18.2
29.9
0.4
90.3
9.20.1
361
581
--
250
--
--
15.30.5
45.01.6
--
--
34.0
--
--
14.61.9
47.65.4
--
--
30.6
--
.09
14.5
43.7
61.8
20.5
33.2
--
5.6
1.5
3.9
0.15
.01
14.9
45.6
65.1
21.2
32.6
--
4.8
1.2
3.5
.18
13.6
41.5
67.1
22.0
32.7
--
3.7
0.7
.57
13.8
42.7
65.0
21.0
32.3
--
6.9
.86
14.0
43.2
63.2
20.4
32.4
--
7.6
21.20.4 33.70.1
3.1-9.2
5.9
38-66 *
3.6
26-51
1.6
0.30
0.44
0.00
181
--
--
--
0.00
--
0.00
--
0.08
--
--
0.06
0.03
--
--
2.9
0.05
0.03
--
--
0.7
6.1
0.12
0.00
--
--
0.7
6.6
0.14
0.09
--
--
90.7
13.71.0
81084
50.7
14.41.0
781120
BC
106
muL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
Platelets
(103 /muL) An
70.5
15.40.6
62575
70.4
15.80.5
61986
30.3
15.10.5
51259
20.4
15.30.7
57381
30.3
13.90.5
38.04.9
--
--
--
--
0.030.03
--
--
60.2
14.40.4
38.11.4
--
--
--
--
--
--
40.4
13.90.7
--
1064191
60.4
14.20.6
--
1061217
50.8
14.61.5
--
855211
40.5
14.01.0
--
978234
50.6
15.30.8
--
795137
50.5
14.50.6
--
851165
80.3
13.10.7
37.31.9
--
--
--
--
--
--
40.5
14.040.8 44.33.5
--
--
--
--
0.00.0
1.20.9
--
--
70.1
12.62.6
38.11.3
--
--
--
--
0.00.0
0.030.05
--
--
16.6
52.5
108.0
35.2
31.4
1.0
0.35
0.02
0.00
--
35.01.0
32.1
9.9
30.9
--
24.0-49.0
23.048.0
--
29.035.0
--
4.0-12.0 1.0-5.0
4.5
900.2 10.80.3
-15.0
8.0-16.0
4.4
2.6
1.4
2.0-9.0
0.00.0
2.0-9.0
0.1-0.75
rare
-300-800
BC
106
muL)
HGB
(g/dL)
VPRC
(mL/dL)
MCV
(fL)
MCH
(pg)
MCHC
(g/dL)
Retics
(%)
WBC
(103
/muL)
Neutro Lymph
(103 / (103
muL) /muL)
Mono
(103
/muL)
Eos (103
/muL)
Baso
(103
/muL)
2.0
11.5
35.0
34.0
10.0
32.5
0.0
8.0
2.4
5.0
0.20
0.40
0.05
400
10
15.1
51.4
54.0
16.0
30.0
--
16.0
7.7
6.7
0.48
1.12
0.00
540
16.2
45.0
113.0
40.5
36.0
--
10.4
8.4
1.6
0.31
0.21
0.00
256
6.6
53.5
16.7
71.3
23.3
32.9
--
15.0
12.0
1.8
0.61
0.87
--
--
7.4
17.2
53.5
72.3
23.7
32.9
--
12.0
8.1
1.4
0.65
0.63
--
--
8.5
14.2
39.0
46.1
16.5
34.3
0.1
8.1
5.1
2.6
0.32
0.08
0.00
214
Platelets
(103 /muL) An
ells; HGB, hemoglobin; VPRC, volume of packed red cells; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpus
ion; Retics, reticulocytes; WBC, white blood cells; Neutro, neutrophils; Lymph, lymphocytes; Mono, monocytes; Eos, eosinophils; Baso, basophils.
(a) Ragan HA, Debban KH, Romsos CO, Redezke D, Weller RE, Buchanan J. Hematology and clinical
chemistry values in common laboratory animals. Manuscript in preparation.
*Leukocyte differential in percent.
2756
Species
Author
RBC
(106
/muL)
HGB
(g/dL)
Wintrobe
0.44
7.8
VPRC MCV
(mL/dL) (fL)
MCH
(pg)
MCHC
(g/dL)
WBC
(103
/muL)
179
27
0.15
2.6
0.00
0.21
--
--
--
--
--
--
--
--
--
--
24
--
--
--
--
--
7.0
Amphibia
rog
oad
29.3
670
[12]
Amphiuma Wintrobe
[12]
0.03
9.4
40.0
13860
3290
Species
Author
RBC
(106
/muL)
Cryptoranchus
Wintrobe
0.07
13.3
49.0
7425
2010
27
1.9
1.00
0.76
--
0.10
0.10
--
0.67
8.2
30.0
450
123
27
--
--
--
--
--
--
--
0.81
4.4
13.8
171
54
32
--
--
--
--
--
--
--
1.05
8.5
28.0
267
82
31
--
--
--
--
--
--
--
0.74
6.2
22.1
300
85
28
--
--
--
--
--
--
--
HGB
(g/dL)
VPRC MCV
(mL/dL) (fL)
MCH
(pg)
MCHC
(g/dL)
WBC
(103
/muL)
[12]
Reptiles
Alligator
izard
nake
urtle
Wintrobe
[12]
Wintrobe
[12]
Wintrobe
[12]
Wintrobe
[12]
Birds
Duck
Magath et
al [61]
3.06
15.6
--
--
--
--
23.4
5.7
14.4
2.50
.40
.35
30.7
Chicken
Lucas et
al [62]
2.96
10.7
31.9
107.7
36.1
33.5
28.9
6.8
20.7
0.33
0.41
0.59
37.2
Guinea
Wintrobe
3.69
14
50.0
136
38
28
1.6
1.1
--
5.12
0.16
--
2.82
12.7
44.6
160
45
29
--
5.5
--
0.48
--
--
Goose
[12]
Wintrobe
[12]
igeon
Magath
et al [61]
3.53
14.4
--
--
--
--
16.7
0.6
0.50
5.88
0.67
37
urkey
Wintrobe
1.93
11.2
39.2
203
58
29
--
--
--
--
--
--
--
[12]
ishes
almon
Nieminen
et al [63]
--
--
35.41.2
--
--
--
--
--
--
--
--
--
--
Rainbow
rout
Nieminen
et al [63]
--
--
37.91.0
--
--
--
--
--
--
--
--
--
--
Carp
Field et al
0.84
10.5
31.3
311
72
34
--
--
--
--
--
--
--
135
31.9
23.6
37.930.3
0.71
32.1
4.66
0.47
0.01
37.821.0
Mackerel
rout
Rock Cod
lounder
[64]
Martins
et al [65]
Field et al
8.5
27.2
314
75
31
--
--
--
--
--
--
--
1.49
5.2
23.8
159
35
22
--
84.0 *
6.0
10.0
--
0.78
2.1
8.34
108
28
25
6.0
0.12
5.6
0.24
--
[64]
Wintrobe
[12]
Wintrobe
[12]
Species
kate
Dogfish
Dogfish
Author
RBC
(106
/muL)
HGB
(g/dL)
MCH
(pg)
MCHC
(g/dL)
WBC
(103
/muL)
Wintrobe
0.10
1.6
9.9
952
153
16
--
--
--
--
--
--
--
0.07
1.4
7.3
1010
195
19
45.0
--
--
--
--
--
--
0.39
4.4
--
--
112
--
83.5
4.2
55.5
0.84
14.61
13.5
VPRC MCV
(mL/dL) (fL)
[12]
Wintrobe
[12]
Reznikoff
et al [66]
Abbreviations: RBC, red blood cells; HGB, hemoglobin; VPRC, volume of packed red cells; MCV, mean corpuscular volume; MCH, mean corpuscular
hemoglobin; MCHC, mean corpuscular hemoglobin concentration; WBC, white blood cells; Neutro, neutrophils; Lymph, lymphocytes; Mono, monocytes
Eos, eosinophils; Baso, basophils.
*Leukocyte differential in percent.
2757
mice, and may become evident with even minimal bone marrow stress. Tremendous variation is noted in
the diameter and volume ranges of the red cells when interspecies comparisons are made. Values for red
cell mass and red cell life span, although not included in the tables, may be found in many of the
references. Many in-depth studies concerning hemoglobins of various animals have been performed and
references are present in the Suggested Readings for the appropriate species.
[15]
[16]
References
1. Hawkey
RK, Jeffcott LB. Comparative Clinical Hematology. Oxford: Blackwell Scientific 1977.
4. Hawkey
CM, Dennett TB. Color atlas of comparative veterinary hematology. Ames: Iowa State
University Press, 1989.
5. Lawkowicz
DJ, Coles EH, Rich LJ. Veterinary laboratory medicine: Interpretation and diagnosis. WB
Saunders Company. Philadelphia: 1992.
7. Mitruka
BV, Rawnsley HM. Clinical, biochemical and hematological reference values in normal
experimental animals and normal humans. New York: Masson, 1981.
8. Payne
BJ, Lewis HB, Murchison TE, Hart EA. Hematology of laboratory animals. In Handbook of
Laboratory Animal Science, Vol. 3, EC Melby, NH Altman, eds. Boca Raton: CRC Press, 1976.
9. Sanderson
10. Schalm's
JH, Phillips EC. An atlas of laboratory animal hematology. Oxford: Clarendon Press, 1981.
Veterinary Hematology. 4th ed. Jains NC, ed. Philadelphia: Williams & Wilkins, 1986.
11. Schermer
12. Wintrobe
MM. Variations in the size and hemoglobin content of erythrocytes in the blood of various
vertebrates. Folia Haematol 1933;51:32.
13. Wolford
ST, Schroer RA, Gohs FX, et al. Reference range data for serum chemistry and hematology
values in laboratory animals. J Tox Environ Health 1986;18:161-188.
14. Dodds
WJ, EJW Bowie, KM Brinkhouse et al, eds. Workshop on animal models of thrombosis and
hemorrhagic diseases. Washington, DC: National Academy of Sciences, 1975.
15. Didisheim
P et al. Hematologic and coagulation studies in various animal species. J Lab Clin Med
1959;53:866.
16. Rowsell
HC, Mustard JF. Blood coagulation in some common laboratory animals. Lab Anim Care
1963;13:752.
17. Cuba-Caparo
GH, et al. Hematologic parameters for wild and captive ninebanded armadillos (Dasypus
novetninctus). Lab Anim Sci 1978;28:607.
19. Sedgwick
CJ, Simpson JG, Schalm OW: Clinical hematology in zoo animals. I. Hemograms. Am J Vet
Clin Pathol 1967; 1:105-114.
20. McEwan
21. Rohovsky
MW, Griesemer RA. The hematology of the germfree cat. Lab Anim Sci 1969;19:60.
22. Adams
R, Garry FB, Aldridge BM, et al. Hematologic values in newborn beef calves. Am J Vet Res
1992;53:944-950.
23. Strike
TA. Hemogram and bone marrow differential of the chinchilla. Lab Anim 1970;20:33.
24. Michaelson
SM, Scheer K, Gilt S. The blood of the normal beagle. J Am Vet Med Assoc 1966;148:532.
25. Nirmalan
G et al. Hematology of the Indian elephant (Elephas maximus). Can J Physiol Pharmacol
1967;45:985.
26. Lee
EJ, Moore WE, Fryer HC, Minocha HC. Haematological and serum chemistry profiles of ferrets
(Mustela putorius furo). Lab Anim 1982;16:133.
27. Thornton
PC, Wright PA, Sacra PJ, Goodier TEW. The ferret, Mustela putorius furo, as a new species in
toxicology. Lab Anim 1979;13:119.
28. Dillon
WG, Glomski CA. The Mongolian gerbil: Qualitative and quantitative aspects of the cellular
blood picture. Lab Anim 1975; 9:283.
29. Mays
A. Baseline hematological and blood biochemical parameters of the Mongolian gerbil (Meriones
unguiculatus). Lab Anim Care 1969;19:838.
30. Ragan
HA, Horstman VG, McClellan RO, Bustad LK: Application of miniature goats in ruminant
research. Am J Vet Res 1966; 27:161-165.
31. Stevens
JB, Anderson KL, Correa MT, et al. Hematologic, blood gas, blood chemistry, and serum
mineral values for a sample of healthy adult goats. Vet Clin Pathol 1994;23:19-24.
32. Waner
T, Avidar V, Peh HC, et al. Hematology and clinical chemistry values of normal and euthymic
hairless adult male Dunkin-Hartley guinea pigs (Cavia porcellus). Vet Clin Pathol 1996;25:61-64.
33. Dontenwill
R, Mason M. Normal blood and urine values for mink. Cornell Vet 1948;38:79.
36. Henderson
JD, Titus JL. Hematologic and serum protein values in germfree and conventional mice.
Mayo Clin Proc 1968;43:530.
37. Ragan
HA, Phillips RD, Buschbom RL, et al. Hematologic and immunologic effects of pulsed
microwaves in mice. Bioelectromagnetics 1983;4:383-396.
38. Swindle
MM, Hulebak KC, Yarbrough BA. Haematology and pathology of captive southern grasshopper
mice (Onchyomys torridus). Lab Anim 1985;19:195.
38A. Cothran
EG, Haines CK, VandeBerg JL. Age effects on hematologic and serum chemical values in
Gray Short-tailed opossums (Monodelphis domestica). Lab Anim Sci 1990;40:192-197.
39. Burks
MF, Tumbleson ME, Hicklin KW, et al. Age and sex related changes of hematologic parameters in
Sinclair (S-1) miniature swine. Growth 1977;41:51-62.
40. Dungan
LJ, Wiest DB, Fyfe DA, et al. Normal hematology, serology, and serum protein electrophoresis
values in fetal Yucatan miniature swine. Lab Anim Sci 1995;45:285-289.
41. Ragan
HA, Phillips RD, Anderson LE. Biological Studies of Swine Exposed to 60-Hz Electric fields:
Hematology and Serum Chemistry. Final Report to Electric Power Research Institute (Report EA 4318),
Vol. 5. Palo Alto, CA, 1985
42. Hainsey
BM, Hubbard GB, LeLand MM, Brasky KM. Clinical parameters of the normal baboons
(Papio sp.) and chimpanzees (Pan troglodytes). Lab Anim Sci 1993;43:236-243.
43. Hack
CA, Gleiser CA. Hematologic and serum chemical reference values for adult and juvenile baboons
(Papio sp). Lab Anim Sci 1982;32:502.
44. Huser
45. Hambleton
P et al. Normal values for some whole blood and serum components of Grivet monkeys
(Cercopithecus aethiops). Lab Anim 1979;13:89.
46. Malaga
CA, Weller RE, Buschbom RL, Ragan HA. Hematology of the wild-caught karyotype V owl
monkey (Aotus vociferous). Lab Anim Sci 1995;45:574-576.
47. Hawkey
CM, Dean S, Hart MG. The influence of anesthetics on the haematology of the Patas monkey,
Erythrocebus patas . Lab Anim 1978;12:167.
47A. Roberts
J, Mendoza SP. Hematologic and serum chemistry values in Callicebus moloch cupreus . Lab
Anim Sci 1989;39:163-165.
48. Wadsworth
HS, Warthman C, Else JG. Effects of ketamine anaesthesia, stress and repeated bleeding on the
haematology of vervet monkeys. Lab Anim 1985;19:138.
50. Bartolotti A,
Castelli D, Bonati M. Hematology and serum chemistry values of adult, pregnant, and
newborn New Zealand rabbits (Oryctologus cuniculus). Lab Anim Sci 1989;39:437-439.
51. Gadarowski
JJ, Esce JD. Acute systemic changes in blood cells proteins, coagulation, fibrinolysis and
platelet aggregation after frostbite injury in the rabbit. Cryobiology 1974;21:359.
52. Kabata
J, Gratwohl A, Tichelli A, et al. Hematologic values of New Zealand white rabbits determined by
automated flow cytometry. Lab Anim Sci 1991;41:613-619.
53. Hougen
HP, Klausen B. Effects of homozygosity of the nude (rnu) gene in an inbred strain of rat:
Studies of lymphoid and non-lymphoid organs in different age groups of nude rats of LEW background at a
state in the gene transfer. Lab Anim Sci 1984;18:7.
54. Kozma
CK, Weisbroth SH, Stratman SL, Conejeros M. Normal biological values for Long-Evans rats.
Lab Anim Care 1969;19: 746-755.
55. Lovell
DP, Archer RK, Riley J, Morgan RK. Variation in hematological parameters among inbred strains
of rat. Lab Anim 1981;15:243.
56. Smith
D, Bronson R. Clinical chemistry and hematology profiles of the aging rat. Lab Anim 1992:
21:32-45.
57. Ragan
HA, Buschbom RL, Pipes MJ, et al. Hematologic and serum chemistry studies in rats exposed to
60-Hz electric fields. Bioelectromagnetics 1983;4:79-90.
58. Hackett
PL, Gaylor DW, Bustad LK. Blood constituent in Suffolk ewes and lambs. Am J Vet Res
1957;18:338-341.
59. Drag
MD. Hematologic values of captive Mexican wolves. Am J Vet Res 1991;53: 1891-1892.
60. Biswas
HM, Patra PB, Bonal MC. Body fluid and hematologic changes in the toad exposed to 48h of
simulated high altitude. J Appl Physiol 1981;51:794.
61. Magath
TB, Higgins GM. The blood of the normal duck. Folia hematol 1934;51:230.
62. Lucas
AM, Jamroz C. Atlas of Avian Hematology. Monograph 25, Washington, DC: US Dept. of
Agriculture, 1961.
63. Nieminen
JB et al. A study of the blood constituents of carp and trout. J Biol Chem 1942;148:261.
65. Martins
JM, Pitombeira MS. High leukocyte count in fishes. Rev Bras Pesquisas Med Biol 1968;1:89.
66. Reznikoff
P, Reznikoff DG. Hematologic studies in the dogfish (Mustelus canis). Biol Bull 1934;66:115.
Suggested Readings
Baillie AJ, Sim AK: Activation of the fibrinolytic enzyme system in laboratory animals and in man: A
comparative study. Thromb Haemost 1971;25:499.
Dunaway PB, Lewis LL. Taxonomic relation of erythrocyte count, mean corpuscular volume, and bodyweight in mammals. Nature 1965;205:481.
Eccleston E. Normal hematologic values in rats, mice and marmosets. In Comparative clinical hematology.
RK Archer, LB Jeffcott, eds. Oxford: Blackwell Scientific 1977.
Finch CA, Ragan HA, Dyer IA, Cook JD. Body iron loss in animals. Proc Soc Exp Biol Med
1978;159:335.
Fowler JSL. Animal clinical chemistry and hematology for the toxicologist. Arch Toxicol 1982;5:152-159.
Green RA. Hemostasis and disorders of coagulation. Vet Clin North Am 1981;11:289.
Holman HH. A negative correlation between size and number of the erythrocytes in cows, sheep, goats and
horses. J Pathol 1952;64: 379.
Irons RD. Toxicology of the blood and bone marrow. New York: Raven, 1985.
Jensen EC. Comparative veterinary hematology: A bird's eye view. Am J Med Tech 1981;47:985-990.
Jones TC, Ward JM, Mohr U, Hunt RD (eds). Hematopoietic system. International Life Sciences Institute
Monograph on pathology of laboratory animals. New York: Springer-Verlag, 1990.
Kaplan HM. Sex differences in the packed cell volume of vertebrate blood. Science 1954;120:1044.
Keller P, Freudiger U. Atlas of hematology of the dog and cat. Berlin: Paul Parey, 1983.
Kitchen H. Easley CW. Structural comparison of the hemoglobins of the genus equus with those of
ruminants. J Biol Chem 1969; 244:6533.
McGrath J. Assessment of hemolytic and hemorrhagic anemias in preclinical safety assessment studies.
Toxicol Pathol 1993;21:158-163.
Rowley AF, Ratcliffe HA. Vertebrate Blood Cells. New York: Cambridge University Press, 1988.
Tvedten HW. Reference values in small animal clinical diagnosis by laboratory methods. In: Willard,
Tvedten, Turnwald, eds. 2nd ed. Philadelphia: WB Saunders, 1994.
Mammals: Miscellaneous and Rare Mammals and Articles Describing More Than One Species
Adams WH et al: Hematologic observations on the yak (38613). Proc Soc Exp Biol Med 1975;148:701.
Andreasen CB, Gerros TC, Lassen ED. Evaluation of bone marrow cytology and stainable iron content in
healthy adult llamas. Vet Clin Pathol 1994;23:38-42.
Campbell T. Hematology of birds, reptiles, and fish. Topics Vet Med 1992;3:4-8.
Kaplan HM: Techniques of collection in ectotherms of body fluids, excreta and vital products for laboratory
examination. Lab Anim Sci 1968;18:131.
Kiehl AR, Schiller CA. A study of manatee leukocytes using peroxidase stain. Vet Clin Pathol 1994;23: 5053.
Marvin HN, Lug DD: The survival of radiochromium-tagged erythrocytes in pigeons, ducks and rabbits.
Acta Haematol (Basel) 1957;18:239.
Prado JC, Kloetzel JK. Normal hematologic values of various age groups of Calomys callosus (Rodentia
cricetidae). Lab Anim Sci 1995; 45:558-560.
Runkel D et al. The tryptic peptides of coyote (Canis latrans) hemoglobin. Biochem Genet 1974;12:467.
Tvedten H, Korcal D. Automated differential leukocyte count in horse, cattle, and cats using the Technicon
H-1E hematology system. Vet Clin Pathol 1996;25:14-22.
Armadillo
Lewis JH, Doyle AP. Coagulation, protein and cellular studies on armadillo blood. Comp Biochem Physiol
1964;12:61.
Moore DM: Venipuncture sites in armadillos (Dasypus noveminctus). Lab Anim Sci 1983;33:384.
Camel
Cohen WD, Terwilliger NB. Marginal bonds in camel erythrocytes. J Cell Sci 1979;36:97-103.
Lin KTD et al. Studies on camel hemoglobin. Biochim Biophys Acta 1976;434:110.
Cat
Altman NH et al. Intraerythrocytic crystalloid bodies in cats. Blood 1972;39:801.
Baumgartner HR, Thoenen H. Tranzer JP: Accumulation of 5-hydroxydopamine in 5-HT storage organelles
of cat platelets and concomitant changes in platelet aggregation. Experiential 1969; 25:857.
Cramer DV, Lewis RM. Reticulocyte response in the cat. J Am Vet Med Assoc 1972;160:61.
Gilmore CE, Gilmore VH, Jones TC. Bone marrow and peripheral blood of cats: Technique and normal
values. Pathol Vet 1964;1:18.
Jain NC. A staining technique to demonstrate erythrocyte refractile bodies in cat blood. Br Vet J
1969;125:437.
Keller P, Freudiger U. Atlas of hematology of the dog and cat. Berlin: Paul Parey, 1983.
Landsberg JW: The blood picture of normal cats. Folia Haematol 1940;64:169.
Perkins PC, Grindem CB. Evaluation of six cytometric methods for reticulocyte enumeration and
differentiation in the cat. Vet Clin Pathol 1995;24:37-43.
Prasse KW, Kaeberle ML, Ramsey FK. Blood neutrophilic granulocyte kinetics in cats. Am J Vet Res
1973;34:1021.
Sawitsky A, Meyer LM. The bone marrow of normal cats. J Lab Clin Med 1947;32:70.
Schryver HF. The bone marrow of the cat. Am J Vet Res 1963; 24:1012.
Cattle
Abt DA et al. Circadian and seasonal variations in the hemogram of mature dairy cattle. Cornell Vet
1966;56:479-520.
DeFilippi LJ, Hultquist DE. The green hemoproteins of bovine erythrocytes. J Biol Chem 1978;253:2946;
1978;253:2954.
Estergreen VL, Van Demark NL. Adrenalectomy of the calf and its effects on various blood constituents. J
Dairy Sci 1961;44:928.
Ferguson LC et al: On variation in the blood cells of healthy cattle. J Infect Dis 1945;76:24.
Gartner RJW, Ryley JW, Beattie AW. The influence of degree of excitation on certain blood constituents in
beef cattle. Aust J Exp Biol Med Sci 1965;43:713-724.
Kaneko JJ, Mills R. Hematological and blood chemical observations in neonatal normal and porphyric
calves in early life. Cornell Vet 1970;60:52.
Osburn BL, Glenn BL. Acquired Pelger-Huet anomaly in cattle. J Am Vet Med Assoc 1968;152:11.
Schroeder WA, et al. Amino acid sequence of the a-chain of bovine fetal hemoglobin. Arch Biochem
Biophys 1967;120:124.
Tennant B, Asbury AC, Laben RC, et al. Familial polycythemia in cattle. J Am Vet Med Assoc
1967;150:1493-1509.
Wingfield WE, Tumbleson ME. Hematologic parameters as a function of age in female dairy cattle. Cornell
Vet 1973;63:72.
Chinchilla
Paolini RV, Rossman JE, Patel V, Stanievich JF. A reliable method for large volume blood collection in the
chinchilla. Lab Anim Sci 1993;43:524-525.
Tappa B, Amao H, Takahashi A. A simple method for intravenous injection and blood collection in the
chinchilla (Chinchilla laniger). Lab Anim 1989;23:73-75.
Deer
Houston TE et al. Crystallography and oriented single crystal electron microscopy of deer hemoglobin. II.
A hemoglobin that exhibits matchstick-shaped erythrocytes. Biochim Biophys Acta 1978;535:413.
Kitchen H et al. Hemoglobin polymorphism in white-tailed deer. Subunit basis. Blood 1967;29:867.
Simpson CF, Taylor WJ. Ultrastructure of sickled deer erythrocytes. I. The typical crescent and holly leaf
forms. Blood 1974;43:899.
Whitten CF. Innocuous nature of the sickling (pseudosickling) phenomenon in deer. Br J Haematol
1967;13:650.
Wong SC, Huisman THJ. Viscosity and gelation studies in deer hemoglobins. Proc Soc Exp Biol Med
1975;150:581.
Dog
Calvo W, Fliedner TM, Herbst EW, Fache I. Regeneration of blood-forming organs after autologous
leukocyte transfusion in lethally irradiated dogs. I. Distribution and cellularity of the bone marrow in
normal dogs. Blood 1975;46:453.
Carter JM, Brobst D. A comparison of the pH of canine capillary, arterial, and venous blood. J Comp Lab
Med 1969;3:19-24.
Clernmons RM, Meyers KM. Acquisition and aggregation of canine blood platelets: Basic mechanisms of
function and differences because of breed origin. Am J Vet Res 1984;45:137.
Deavers S et al. Changes in red cell volume, venous hematocrit and hemoglobin concentration in growing
beagles. Proc Soc Exp Biol Med 1971;137:299.
Deubelbeiss KA et al. Marrow erythroid and neutrophil cellularity in the dog. J Clin Invest 1975;55:825.
Deubelbeiss KA et al. Neutrophil kinetics in the dog. J Clin Invest 1975;55:833.
Dodds WJ, Packham MA, Rowsell HC, Mustard JF. Factor VII survival and turnover in dogs. Am J Physiol
1968;213:36.
Ederstrom HE, DeBoer B. Changes in the blood of the dog with age. Anat Rec 1946;94:663.
Ewing GO. Familial nonspherocytic hemolytic anemia of basenji dogs. J Am Vet Med Assoc 1969;154:503.
Feldman BF, Madewell BR, O'Neill S. Disseminated intravascular coagulation: Antithrombin, plasminogen
and coagulation abnormalities in 41 dogs. J Am Vet Med Assoc 1981;179:151.
Hai NP. Technical notes on long-term vascular access for more than 12 months in conscious dogs. J
Pharmacol Meth 1982;7:57.
Hall DE: Blood coagulation and its disorders in the dog. Baltimore: Williams & Wilkins, 1972.
Harvey JW, Simpson CF, Gaskin JM. Cyclic thrombocytopenia induced by a rickettsia-like agent in dogs. J
Infect Dis 1978;137:182.
Hovell GJR. Jugular puncture in the dog. Vet Rec 1968;21:289.
Huggins RA et al. Growth in beagles: Changes in body weight, plasma volume, and venous hematocrit.
Pediatr Res 1971;5:193.
Keller P, Freudiger U. Atlas of hematology of the dog and cat. Berlin: Paul Parey, 1983.
Lund JE. Hemoglobin crystals in canine blood. Am J Vet Res 1974; 35:575.
Madewell BR, Feldman BF, O'Neill S. Coagulation abnormalities in dogs with neoplastic disease. Thromb
Haemost 1980;44:35.
Meyer LM, Bloom F. The bone marrow of normal dogs. Am J Med Sci 1943;206:637.
Middleton DJ, Watson ADJ. Activated coagulation times of whole blood in normal dogs and dogs with
coagulopathies. J Small Anim Pract 1978;19:417.
Mulligan RM. Quantitative studies on the blood and bone marrow of newborn mongrel puppies. Anat Rec
1945;91:161.
Pinkerton PH, Fletch SM, Brueckner PJ, Miller DR. Hereditary stomatocytosis with hemolytic anemia in
the dog. Blood 1974;44 557.
Pryor WH, Bradbury RP. Haemobartonella canis infection in research dogs. Lab Anim Sci 1975;25:566569.
Reese MA, McDonald TP, Jones JB. Platelet function studies in dogs with cyclic hematopoiesis. Proc Soc
Exp Biol Med 1976;153:324.
Stokol T, Parry BW, Mansell PD. Factor VIII activity in canine von Willebrand disease. Vet Clin Pathol
1995;24:81-90.
Swisher SN, Young LE. The blood grouping systems of dogs. Physiol Rev 1961;41:495.
Tvedten H, Haines C. Canine automated differential leukocyte count: Study using a hematology analyzer
system. Vet Clin Pathol 1994;23:90-96.
Van Loon EJ et al. Hematology of the peripheral blood and bone marrow of the dog. J Lab Clin Med
1943;28:1575.
Wilkerson RD, Conran PB, Greene SL. Activated coagulation time test: A convenient monitor of
heparinization for dogs used in cardiovascular research. Lab Anim Sci 1984;34:62.
Woodward KT, Berman AR, Michaelson SM, Odland LT. Plasma, erythrocyte, and whole blood volume in
the normal beagle. Am J Vet Res 1968;29:1935-1944.
Yale CE, Balish E. Blood and serum chemistry values of gnotobiotic beagles. Lab Anim Sci 1976;26:633.
Dolphins, Whales, and Seals
Lincoln DR et al. Studies on the hemoglobins of pinnipeds. Blood 1973;41:163.
Medway W, Gerac JR. Hematology of the bottlenose dolphin (Tursiops truncatus). Am J Physiol
1964;207:1367.
Elephant
Simon KJ. Hematological studies on elephants. Indian Vet J 1961; 38:241.
Ferret
Bleakley SP. Simple technique for bleeding ferrets (Mustela putorius furo). Lab Anim 1980;14:59.
Fox JG, Hemes K, Memi SM. Retro-orbital technique for blood collection from the ferret (Mustela
putorius furo). Lab Anim Sci 1984; 34.198.
Marini RP, Jackson LR, Esteves MI, et al. Effect of isoflurane on hematologic variables in ferrets. Am J Vet
Res 1994;55:1479-1483.
Goat
Blunt MH et al: The production of haemoglobin C in adult sheep and goats. Aust J Exp Biol Med Sci
1969;47:601.
Fitzsimmons WM, Sansom BF, Sellwood SA, Mathews PRJ. Blood transfusion and red cell survival in the
goat. Br Vet J 1967;123: 192-196.
Lewis JH. Comparative hematology: Studies on goats. Am J Vet Res 1976;37:601-605.
Nienhuis AW, Bunn HF. Hemoglobin switching in sheep and goats. Science 1974;185:946. J Biol Chem
1978;253:5025.
Wrightstone RN et al. The structure of goat hemoglobins. Arch Biochem Biophys 1970;138:451.
Guinea Pig
Bullock CP. Repetitive blood sampling from guinea pigs (Cavia porcellus). Lab Anim Sci 1983;33:70.
Hochman D, Blanchard J. Simplified method for intravenous dosing and serial blood sampling of
unanesthetized guinea pigs. J Pharm Sci 1983;72:975.
Hudson G. Eosinophil populations in blood and bone marrow of normal guinea pigs. Am J Physiol
1960;198:1171.
Lopez H, Novia J. A technique for repeated collection of blood from the guinea pig. Lab Anim Sci
1977;24:522.
Sawitsky A, Meyer LM. Bone marrow of normal guinea pigs. Blood 1948;3:1050.
Smith E. Certain characteristics of the leukocytes of guinea pig blood with particular reference to the
Kurloff body. Blood 1947; (Suppl 1):125.
Whorton JA. Collecting blood via the anterior vena cava in the guinea pig. Lab Anim 1982;11:66.
Hamster
Cruz WO, Ubatuba F. Blood picture of adult golden hamster (Cricetus auratus) after castration. Proc Soc
Exp Biol Med 1947;65:321.
Ottis K, Tauber OE. Blood platelet counts of the golden hamster, Cricetus auratus . Blood 1952;7:948.
Steward MO et al. Hematological findings in the golden hamster (Cricetus auratus). J Exp Med
1944;80:189.
Yasuokochi Y. Multiple hemoglobins in the golden hamster. Biochim Biophys Acta 1970;221:1.
Horse
Bunn HF, Kitchen H. Hemoglobin function in the horse. Blood 1973;42:471.
Kitchen H. Easley CW. Structural comparison of the hemoglobins of the genus equus with those of
ruminants. J Biol Chem 1969;244: 6533.
Marcelese NA, Figueiras HD, Kremenchuzky S, et al. Red cell survival time in the horse determined with
diisopropyl-phosphofluoridate-P32 . Am J Physiol 1966;28:281-282.
Marcelese NA et al. Erythrokinetics in the horse. Am J Physiol 1965;209:727.
Rawlings CA, Byars TD, Van Noy MK. Activated coagulation test in normal and heparinized ponies and
Moore DM. A simple technique for blood collection in the opossum (Didelphis virginiana). Lab Anim
1984;18:52.
Robinson ES, VandeBerg JL. Blood collection and surgical procedures for the laboratory opossum
(Monodelphis domestica). Lab Anim Sci 1994;44:63-68.
Waterman MR, Stenzel P. Physical and chemical properties of opossum hemoglobin. Biochim Biophys
Acta 1974;359:401.
Pig
Brown JR, Tyeryar EA, Harrington DG, Hilmas DE. Femoral venipuncture for repeated blood sampling in
miniature swine. Lab Anim Sci 1978;28:339.
Bush JA, Jensen WN, Cartwright GE, Wintrobe, MM. Blood volume studies in normal and anemic swine.
Am J Physiol 1955; 181:9-14.
McClellan RO, Vogt GS, Ragan HA. Age-related changes in hematological and serum biochemical
parameters in miniature swine. In: Swine in Biomedical Research. Seattle: Frayn Printing, 1965:597-610.
Ragan HA. Platelet agglutination induced by ethylenediamine tetraacetic acid in blood samples from a
miniature pig. Am J Vet Res 1972;33:2601-2603.
Ragan HA, Gillis MF. Restraint, venipuncture, endotracheal intubation, and anesthesia of miniature swine.
Lab Anim Sci 1965; 25:409-419.
Smith CA, Fichen MD. Non-surgical cannulation of the vena cava for chronic blood collection in mature
swine. Lab Anim Sci 1991; 41:274-278.
Primates (Nonhuman)
Abildgaard CF, Harrison J, Johnson CA. Comparative study of blood coagulation in nonhuman primates. J
Appl Physiol 1971; 30:400.
Banucot NA, Jolly CJ. Haemoglobin polymorphism in the orangutan and an animal with four major
haemoglobins. Nature 1966; 210:640.
Boyer SH et al. Hemoglobins A and A2 in New World primates: Comparative variation and its evolutionary
implications. Science 1969;166:1428.
Burns KF et al. Compendium of normal blood values for baboons, chimpanzees, and marmosets. Am J Clin
Pathol 1967;48:484.
Calhoun ML. A cytological study of costal marrow. Am J Vet Res 1954;15:181; 15:395; Am J Vet Res
1955;16:297.
Guilietti M, La Torre R, Pace M, et al. Reference blood values of iron metabolism in cynomolgus
macaques. Lab Anim Sci 1991; 41:606-608.
Hampton JW, Mathews C. Similarities between baboon and human blood clotting. J Appl Physiol
1966;21:1713.
Hearn JP, Lunn SF, Burden IJ, Pildher MM. Management of marmosets for biomedical research. Lab Anim
1975;9:125.
Hill RL et al. Evolution of hemoglobin in primates. Proc Natl Acad Sci U S A 1963;50:885.
Jones ES et al. The effect of diet on the hemoglobin, erythrocyte, and leukocyte content of the blood of the
Rhesus monkey (Macaca mulatta). Blood 1947;2:154.
Kitchen H et al. Hemoglobin types of adult, fetal, and newborn subhuman primates: Macaca speciosa .
Arch Biochem Biophys 1968; 123:227.
Loeb WF, Mackey B. A comparative study of platelet aggregation in primates. J Med Prim 1973;2:195-205.
Malaga CA, Weller RE, Buschbom RL, Ragan HA. Hematology of the wild-caught karyotype I owl
monkey (Aotus nancymai). Lab Anim Sci 1990;40:205-206.
Nute PE, Stamatoyannopoulos G. The ontogenesis of hemoglobins in Macaca nemestrina . Blood
1971;38:108.
Oxnard CE, Smith WT, Torres I. Vitamin B deficiency in captive monkeys and its effect on the nervous
system and the blood. Lab Anim 1970;4:1.238.
Schiffer SP, Gillett CS, Ringler DH. Activated coagulation time for Rhesus monkeys (Macaca mulatta).
Lab Anim Sci 1984;34:191.
Switzer JW et al. Hematologic changes associated with pregnancy and parturition in Macaca mulatta . Lab
Anim Sci 1970;20:930.
Walcott GJ, Valentine JA, Cebul RD. Induction of anaemia in monkeys. Lab Anim 1973;7:297.
Weber HW et al. The baboon in medical research: Baseline studies in fourteen hundred baboons and
pathological observations. In: Defining the laboratory animal. Washington DC National Academy of
Sciences, 1971.
Rabbit
Dietz AA. Composition of normal bone marrow in rabbits. J Biol Chem 1946;165:505.
Ishibashi S et al. Evidence for dimorphism in rabbit hemoglobins. Proc Soc Exp Biol Med 1968;128:879.
King JE, Ackerman GA. Erythropoiesis in the bone marrow of the fetal rabbit. Anat Rec 1967;157:589.
Paulsen R, Valentine JL. A procedure for intravenous administration of drugs and repeated arterial blood
sampling in the rabbit. Lab Anim 1984;13:34.
Perry-Clark LM, Meunier LD. Vascular access ports for chronic serial infusion and blood sampling in New
Zealand white rabbits. Lab Anim Sci 1991;41:495-497.
Pintor PP, Grassini V. Individual and seasonal spontaneous variations of haematological values in normal
male rabbits. Acta Haematol (Basel) 1957;17:122.
Smith GN, Mollison PL. Normal red cell survival in the rabbit. Scand J Haematol 1973;11:188.
Sutherland DA et al. The life span of the rabbit erythrocyte. Acta Haematol (Basel) 1959;21:36.
Tillman P, Normal C. Droperidol-fentanyl as an aid to blood collection in rabbits. Lab Anim Sci
1983;33:181.
Rat
Angelov O et al. A comparison of two methods of bleeding rats: The venous plexus of the eye versus the
vena sublingualis. J Appl Toxicol 1984;4:258.
Archer RK, Riley J. Standardized method for bleeding rats. Lab Anim 1981;15:25.
Belcher EH, Harris EB. Studies of red cell life span in the rat. J Physiol (Lond) 1959;146:217.
Berlin N: A simple method for repeated bone marrow aspirations in rats. Proc Soc Exp Biol Med
1948;69:53.
Bickhardt K, Buttner D, Muschen U, Plonait H. Influence of bleeding procedure and some environmental
conditions on stress-dependent blood constituents of laboratory rats. Lab Anim 1983; 17:161.
Burke WT, Harris C. Total cell counts of the bone marrow of normal albino rats from 1 to 50 weeks of age.
Blood 1959;14:409.
Cameron DG, Watson GM. Femoral bone marrow biopsy in the albino rat. Blood 1948;3:292.
Cocchetto DM, Bjornosson TD. Methods for vascular access and collection of body fluids from the
laboratory rat. J Pharm Sci 1983; 72:465.
Dameron GW, Weingand KW, Duderstadt JM, et al. Effect of bleeding site on clinical laboratory testing of
rats: Orbital venous plexus versus posterior vena cava. Lab Anim Sci 1992;42:299-301.
Datta MC, Dukes PP. Comparison of the effects of crude and purified erythropoietin on the synthesis of
hemoglobin in rat bone marrow cell cultures. Exp Hematol 1982;10:689.
Frith CH, Ward JM, Chandra M. The morphology, immunochemistry, and incidence of hematopoietic
neoplasms in mice and rats. Tox Path 1993;21:206-218
Garrick LM et al. Rat haemoglobin heterogeneity. Biochem J 1975; 149:245.
Gilman JG, Datta MC. Rat hemoglobin heterogeneity: Genetic variation affecting hemoglobin preparations.
Hemoglobin 1982; 6:439.
Godwin KO et al. Haematological observations in healthy (SPF) rats. Br J Exp Pathol 1964;45:514.
Khan KNM, Komocsar WJ, Lazzaro NC, et al. Effect of bleeding site on clinical pathologic parameters in
Sprague-Dawley rats: Retro-orbital plexus versus abdominal aorta. Contemp Top 1996:35:63-66.
Marit GB, Young SM, Hadick CL. Anatomic and physiologic characterization of the WF/PmWP-``f 2 ''
(Fuzzy) rat. Lab Anim Sci 1995;45:184-190.
Mohr U. International classification of rodent tumours. Part I--The rat. 4. Haematopoietic system. IARC
Scientific Publications No. 122. Lyon, France, 1993.
Putcha L, Bruckner JV, Muralidhara S, Feldman S. A simple method for repetitive blood sampling from
rats. J Pharm Meth 1982; 8:145.
Quimby FH et al. Total white cell counts of peripheral and heart blood of the rat. Science 1948;107:447.
Ragan HA, Pipes MJ, Kaune WT, Phillips RD. Clinical-pathologic evaluations in rats and mice chronically
exposed to 60-Hz electric fields. In: Biological effects of extremely low frequency electromagnetic fields.
Conf-781016, NTIS. Springfield, VA, 1979: 297-325.
Reese ME. An Investigation of the Effects of tobacco smoke and nicotine on rat blood platelet functions.
Ph.D. Thesis. Ann Arbor University Microfilms, 1974
Shek PN, Howe SA. A novel method for the rapid bleeding of rats from the tail vein. J Immunol Meth
1982;53:255.
Snitily MU, Gentry MJ, Mellencamp MA, Preheim LC. A simple method for collection of blood from the
rat foot. Lab Anim Sci 1991; 41:285-287.
Tarbutt RG. Cell population kinetics of the erythroid system in the rat. The response to protracted anaemia
and to continuous gamma irradiation. Br J Haematol 1969;16:9.
Tarbutt RG. A study of erythropoiesis in the rat. Exp Cell Res 1967; 48:473.
Upton PK, Morgan DJ. The effect of sampling technique on some blood parameters in the rat. Lab Anim
1975;9:85.
Urizar RE, Cerda J, Dodds WJ, et al. Age-related renal, hematologic, and hemostatic abnormalities in
FH/Wjd rats. Am J Vet Res 1984;45:1624-1631.
van Putten LM: The life span of red cells in the rat and the mouse as determined by labeling with DFP 32 in
vivo. Blood 1958;13:789.
Wiegmann TB, Antzer D. Use of an extracorporeal anterior venous shunt and capillary tubes for frequent
micro-blood sampling in rats. J Pharm Meth 1983;9:7-18.
Williams DM, Gillett R, Linder JE. Light and electron microscope alkaline phosphatase cytochemistry of
rat bone marrow leukocytes. J Histochem Cytochem 1979;27:665.
Winocour PD et al. Changes in the properties of platelets from rats with experimentally induced shortened
platelet survival. J Lab Clin Med 1983;101:175.
Sheep
Battaglia FC et al. Exposure to high altitude of sheep with different haemoglobins. Q J Exp Physiol
1969;54:423.
Blunt MH, et al. The production of haemoglobin C in adult sheep and goats. Aust J Exp Biol Med Sci
1969;47:601.
Georgi JR, Hertzendorf II. Simultaneous erythrocyte and plasma volume measurements in sheep using
iron-59. Cornell Vet 1964; 54:510.
Morgan Dl, Upton PK. The effect of sampling technique on acid-base balance and other parameters in the
sheep. Lab Anim 1975; 9:93.
Nienhuis AW, Bunn HF. Hemoglobin switching in sheep and goats. Science 1974;185: 946;J Biol Chem
1978;253:5025.
Todd JR, Ross JG. Biochemical and haematological changes in the blood of normal sheep following
repeated phlebotomy. Br Vet J 1968; 124:353-361.
Vertebrates Other Than Mammals
Amphibians and Reptiles
Alleman AR, Jacobson ER, Raskin RE. Morphological and cytochemical characteristics of blood cells from
desert tortoise (Gopherus agassizii). Am J Vet Res 1992;53:1645-1651.
Baranowski-Smith LL, Smith DJ. A simple method of obtaining blood samples from mature frogs. Lab
Anim Sci 1983;33:386.
Bardsley JE, Harmsen R. A simple and inexpensive methodology for the care and maintenance of
experimental laboratory frogs. Lab Anim 1972;6:95.
Bergman RAM. The erythrocyte of snakes. Folia Haematol 1957; 75:92.
Broyles RH, Frieden E. Sites of haemoglobin synthesis in amphibian tadpoles. Nature 1973;241:207.
Caxton-Martins AE. Cytochemistry of blood cells in peripheral smears of some West African reptiles. J
Anat 1977;124:393.
Edwards JA, Justus JT. Hemoglobins of two urodeles: Changes with metamorphosis. Pros Soc Exp Biol
Med 1969;132:524.
Friar W. Turtle red blood cell packed volumes, sizes, and numbers. Herpetologica 1977;33:167.
Friar W. Sea turtle red blood cell parameters correlated with carapace lengths. Comp Biochem Physiol
1977;56A:467.
Friedmann GB et al. Determination of the red blood cell count and haemoglobin content of urodele blood.
Anat Rec 1969;163:55.
Gottdenker NL, Jacobson ER. Effects of venipuncture sites on hematologic and clinical biochemical values
in desert tortoises (Gopherus agassizii). Am J Vet Res 1995;56:19-21.
Herman CA, Caputo F, Magliola L, deRoos R. An improved cannulation technique for prolonged blood
sampling of the American bullfrog. Lab Anim Sci 1978;28:335.
Krishamoorty RV, Shakunthala N. Increased RBC count and pulmonary respiration in cold-adapted frogs. J
Exp Biol 1974; 61:285-290.
Ryerson DL. Separation of the two acidophilic granulocytes of turtle blood with suggested phylogenetic
relationships. Anat Rec 1943;85:25.
Sullivan B. Oxygenation properties of snake hemoglobin. Science 11967;57:1308.
Sullivan B, Riggs A. The subunit dissociation properties of turtle hemoglobins. Biochem Biophys Acta
1967;140:274.
Birds
Campbell TW. Avian hematology and cytology. Ames: Iowa State University Press, 1988.
D'Amelio V. The globins of adult and embryonic chick hemoglobin. Biochim Biophys Acta 1966;27:59.
Dorrestein GM, Blaauboer BJ, Miltenburg NA, Deley PP. A modified method of blood sampling from
birds. Lab Anim 1978; 12:193.
Dupont CH. The site of hemoglobin synthesis in the avian erythrocyte. Biochem Med 1973. 8:228.
Fraser R et al. The multiple hemoglobins of the chick embryo. J Cell Physiol 1972;80:79.
Johnston PM. Hematocrit values for the chick embryo at various ages. Am J Physiol 1955;180:361.
Ottesen J. Life-span of red and white blood corpuscles of the hen. Nature 11948 62:730.
Rodnan GP et al. The life span of the red blood cell and the red blood cell volume in the chicken, pigeon,
and duck as estimated by the use of Na2 Cr51 O4 . Blood 1957;12:355.
Fishes
Amend DF, Smith L. Pathophysiology of infectious hematopoietic necrosis virus disease in rainbow trout
(Salmo gairdneri) : Early changes in blood and aspects of the immune response after injection of IHN
virus. J Fish Res Board Can 1974;31:1371-1378.
Bannai S et al. Studies on hemoglobin from the hagfish Eptatretus burgeri . J Biol Chem 1972;247:505.
Binotti I et al: Studies on the functional properties of fish hemoglobins. II. The oxygen equilibrium of the
isolated hemoglobin components from trout blood. Arch Biochem Biophys 1971;142:274.
Blaxhall PC. The haematological assessment of the health of freshwater fish: A review of selected
literature. J Fish Biol 1972; 4:593-604.
Buhler DR. Studies on fish hemoglobins. J Biol Chem 1963; 238:1665.
Catton WT. Blood cell formation in certain teleost fishes. Blood 1951;6:39.
Coburn CB Jr, Fischer BA. Red blood cell hematology of fishes: A critique of techniques and a compilation
of published data. J Marine Sci 1973;2:37.
Dohi Y et al. The self-association and oxygen equilibrium of hemoglobin from the lamprey, Entoshenus
japonicus. J Biol Chem 1973;248:2354.
Hawkins R, Mawdesley-Thomas LE. Fish haematology--a bibliography. J Fish Biol 1972;4:193-232.
Katz M. The number of erythrocytes in the blood of the silver salmon. Trans Am Fish Soc 1951;80:184.
McLeay DJ, Gordon MR. Leucocrit: A simple hematological technique for measuring acute stress in
Salmonid fish, including stressful concentrations of pulpmill effluent. J Fish Res Board Can 1977;34:21642175.
Powers DA. Hemoglobin adaptations for fast and slow water habitats in sympatric catostomid fishes.
Science 1972;177:360.
Rumen NM, Love WE. The six hemoglobins of the sea lamprey (Petromyzlm marinus). Arch Biochem
Biophys 1963;103:24.
Srivastaga AK. Studies on the hematology of certain freshwater teleosts. Anat Anz 1968;123:233; Folia
Haematol 1968;90:4.
Stokes EE, Firkin BG. Studies of the peripheral blood of the Port Jackson shark (Heterodontus
portusjacksoni) with particular reference to the thrombocyte. Br J Haematol 1971;20:427.
Van Dam L, Scholander PF. Concentration of hemoglobin in the blood of deep sea fishes. J Cell Comp
Physiol 1953;41:1.
Weber RE et al. The hemoglobin system of the primitive fish Amia calva : Isolation and functional