Peter Parham

The Immune System

Fourth Edition
Chapter 2
Innate Immunity: The Immediate
Response to Infection

Copyright Garland Science 2015

CHAPTER CONTENTS
2-1

2-2
2-3
2-4
2-5
2-6

Physical barriers colonized by commensal

microorganisms protect against infection by
pathogens
Intracellular and extracellular pathogens
require different types of immune response
Complement is a system of plasma proteins
that mark pathogens for destruction
At the start of an infection, complement
activation proceeds by the alternative pathway
Regulatory proteins determine the extent and
site of C3b deposition
Phagocytosis by macrophages provides a first
line of cellular defense against invading
microorganismstes

CHAPTER CONTENTS
2-7

The terminal complement proteins lyse

pathogens by forming membrane pores
2-8 Small peptides released during complement
activation induce local inflammation
2-9 Several classes of plasma protein limit the
spread of infection
2-10 Antimicrobial peptides kill pathogens by
perturbing their membranes
2-11 Pentraxins are plasma proteins of innate
immunity that bind microorganisms and target
them to phagocytes

Innate Immunity: the Immediate

Response to Infection
2-1

Physical barriers colonized by commensal

microorganisms protect against infection by
pathogens

2-1 Physical barriers colonized by commensal microorganisms

protect against infection by pathogens

Innate Immunity: the Immediate

Response to Infection
2-2

Intracellular and extracellular pathogens

require different types of immune response

2-2 Intracellular and extracellular pathogens require different types

of immune response

Innate Immunity: the Immediate

Response to Infection
2-3

Complement is a system of plasma proteins

that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens

for destruction

2-3 Complement is a system of plasma proteins that mark pathogens

for destruction

2-3 Complement is a system of plasma proteins that mark pathogens

for destruction

Innate Immunity: the Immediate

Response to Infection
2-4

At the start of an infection, complement

activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by

the alternative pathway

2-4 At the start of an infection, complement activation proceeds by

the alternative pathway

2-4 At the start of an infection, complement activation proceeds by

the alternative pathway

Innate Immunity: the Immediate

Response to Infection
2-5

Regulatory proteins determine the extent and

site of C3b deposition

2-5 Regulatory proteins determine the extent and site of C3b

deposition

Innate Immunity: the Immediate

Response to Infection
2-6

Phagocytosis by macrophages provides a first

line of cellular defense against invading
microorganisms

2-6 Phagocytosis by macrophages provides a first line of cellular

defense against invading microorganisms

Innate Immunity: the Immediate

Response to Infection
2-7

The terminal complement proteins lyse

pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

2-7 The terminal complement proteins lyse pathogens by forming

membrane pores

Innate Immunity: the Immediate

Response to Infection
2-8

Small peptides released during complement

activation induce local inflammation

2-8 Small peptides released during complement activation induce

local inflammation

Innate Immunity: the Immediate

Response to Infection
2-9

Several classes of plasma protein limit the

spread of infection

2-9 Several classes of plasma protein limit the spread of infection

Innate Immunity: the Immediate

Response to Infection
2-10 Antimicrobial peptides kill pathogens by
perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their

membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their

membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their

membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their

membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their

membranes

Innate Immunity: the Immediate

Response to Infection
2-11 Pentraxins are plasma proteins of innate
immunity that bind microorganisms and target
them to phagocytes

2-11 Pentraxins are plasma proteins of innate immunity that bind

microorganisms and target them to phagocytes