A 10 year old female from Muntinlupa came in to the ER for 3 days history of
bloody diarrhea and vomiting with associated fever and loss of appetite
On PE, (+) lethargic, BP 7-/30 HR 146 bpm RR 30 Temp 40 thready pulses, cold
clammy extremities
Definition:
Acute, complex state of circulatory dysfunction
Results in failure to deliver sufficient amounts of oxygen to meet tissue
metabolic demands
If prolonged, lead to multi-organ failure or death
Early diagnosis
Delivery of Oxygen
Dependent on
Cardiac output
Cardiac output HR x SV
Stages of Shock
1.
Compensated Shock
Vital organ function maintained by intrinsic regulatory mechanisms
2.
Uncompensated Shock
Cardiovascular systems ability to maintain perfusion in inadequate
3.
Irreversible Shock
Significant damage to key organs that death occurs despite therapeutic
response
Recognition and Assessment of Shock
Skin
Mucous membranes
Nailbeds
Pulse
Vital Signs
Sensorium
Respiration Urine
Blood pressure
Hypoxemia
Types of Shock
1.
Hypovolemic
2.
Cardiogenic
3.
Distributive
4.
Septic
5.
Anaphylactic
Goals of Therapy
External bleeding
Internal bleeding
GIT vessel injury
Intracranial
Fracture
Plasma loss
Burns
Capillary leak
Protein losing
Fluid and electrolyte loss
Diarrhea
Diuretics
Endocrine
Cardiogenic Shock
Rhythm abnormalities
Cardiomyopathy/ Carditis
Hypoxic/ ischemic events
Infections
Metabolic
Connective tissue
Toxic reaction
Tachydysrrythmia
Other
Congenital heart
Trauma
Principles of Management
Airway
Breathing
Circulation
Isotonic solution: 20 ml/kg initial bolus
Endpoint: increase BP, tissue perfusion, urine output
Diagnostic Tools
Lab work-up
Serum electrolytes
BUN, Creatinine
Imaging
Chest X-ray
Echocardiography
Electrocardiography
CT-Scan
Therapy
Cardiogenic Shock
Decrease myocardial demand
Increase myocardial performance
Distributive Shock
Misdistribution of blood flow/ vasopressors
Anaphylaxis, spinal anesthesia, etc.
Reverse etiology, vigorous fluid management
Septic Shock
Sepsis with hypotension despite adequate fluid resuscitation along with
perfusion abnormalities/ interplay of various factors
Identify and control infection and rapid reversal of cardiovascular
dysfunction
Nutrition
Dengue Shock Syndrome
Symptoms
Fever for 2-7 days
Positive tourniquet test
Signs of bleeding
Thrombocytopenia
Prolonged BT, PTT evidence of circulatory failure
Pathophysiology
Capillary membrane leak leading to decreased intravascular volume
Normal BP Compensated Shock
Total body water may be normal
Principles of Therapy
Immediate assessment of cardio-respiratory system and degree of
electrolytes, acid-base and hemoconcentration
ABCs of resuscitation
In shock, isotonic solutions 0 20 ml/kg rapid infusion
FFP/ cryoprecipitate
Avoid large volumes of dextrose containing solutions
Burn Injuries
45 C protein desaturation
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Burn Injuries
Mild (<10%)
Moderate (10-30%)
Severe (>30%)
Hospitalization required if >10% burns or when face, hand, feet and genitalia
involved
Zone of hyperemia borders unaffected tissue; minimal injury and recovers 710 days
Therapy
ABCs
Epidemiology
Peak incidence
Pathophysiology
Functional Residual Capacity I the only source of gas exchange in the
submerged state
10-15% with laryngospasm leading to Dry Drowning and Asphyxia
Aspiration of 1-3 cc/kg leads to impairment of gas exchange
Management
Aggressive and Basic life support at the scene
Major determinant of survival is management o hypoxia and acidosis
Positive Pressure Ventilation with the highest possible oxygen
concentration
Isotonic fluids if in shock
Maintenance fluids with appropriate electrolyte contents if stable
Check for other injuries
Child abuse?
Need for hospitalization is determined by the severity of submersion and
clinical evaluation
Observe for 4-6 hours
Admission for abnormal ABG, hypoxemia, altered sensorium and distress
Definitions
Sepsis
Evidence of infection + systemic response elevated temperature,
tachycardia, increased respiration, leukocytosis or an impaired peripheral
leukocyte response and / or the presence of immature band forms in the
peripheral circulation
Sepsis Syndrome
Sepsis with evidence of altered organ, perfusion and at least one of the
following: hypoxemia, elevated lactate concentration, oliguria, altered
mentation
Septic Shock
Refers to sepsis syndrome + hypotension despite adequate fluid
resuscitation
Signs and symptoms suggesting a systemic bacterial infection as the cause of sepsis
Primary
Fever
Chills
Hyperventilation *
Skin lesions
Change in mental status
Secondary
Hypotension
Bleeding
Leukopenia
Thrombocytopenia
Organ Failure:
Lung cyanosis, acidosis
Kidney oliguria, anuria, acidosis
Liver - jaundice
Heart congestive failure
Clinical Manifestations
Fungal, viral pathogens can also cause septic shock but less common
Diagnosis
Rationale:
Treatment can be complicated by a compromised immune system
resulting from an underlying disease or its treatment may be helpful to
enhance immune system activity
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Anaphylaxis
Epidemiology
True incidence of anaphylaxis in unknown
Estimate of the risk of anaphylaxis per person in US is <1-3%
Occurs in all age groups but I more common in adults due to increased
time for exposure and sensitization
Patterns
1.
Acute explosives onset within seconds to minutes of exposure to
triggering event
2.
Biphasic followed by a reaction 3-8 hours after initial reaction (5-20% of
cases)
3.
Protracted lasts 3-21 days from onset of acute reaction
Fatal
Allergic Reactions
Clinical manifestations
The sign and symptom are highly variable and can range from mild
cutaneous symptoms to a fatal reaction
Reaction begins within seconds or minutes after exposure to the allergen
Initial fright or sense of impending doom
Systemic signs:
Hypotension
Bronchospasm or dyspnea
Laryngeal/pharyngeal edema, stridor or dysphonia
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