D R U G S T U D Y

PREPARED BY: NALMALYN S. SHALIM, BSN III – NCM 101, B, GROUP # 8

Drug Brand Pharmacologic Adverse/Side Contrain- Nursing
(Generic Name, Name Action of the Effects of Drug dications Responsibiities/Precauti
Dosage, Route,
Frequency & Drug ons
Indication)
1. Oxytocin Pitocin, Acts on smooth muscle CV: Cardiac arrhythmia, Hypersensitivity to  Note reasons for therapy, onset,
Parenteral, Syntocinon of the uterus to hypertensive episodes, drug. Significant characteristics of S&S. Note any sensitivity
PVCs CPD; unfavorable to drug.
Classification: stimulate contractions:  Determine fetal maturity (size), pelvic
Oxytocic Drug response depends on GI: N&V, stomach pain, fetal positions or
adequacy, fetal presentation/position and
cramping presentations that
Dosage: the uterine threshold lack of complications prior to initiatin drug
CNS: Headache, are undeliverable therapy.
 IV Infusion (drip of excitability. Is dizziness without conversion
method) For induction or  Inform client for rationale of using
selective for the GU: Pelvic hematoma, prior to delivery. In oxytocic agents and reassure that this
stimulation of labor.
Initial: 0.5-2 uterus, especially postpartum hemorrhage. OB emergencies procedure is not unusual. Explain drug will
milliunits/min. Increase toward the end of Rupture of the uterus, where the benefit- induce contractions that may feel like
dose gradually in pregnancy, during menstrual cramps initially but can be very
spasm, titanic to-risk ratio for
increments of no more painful; analgesics may be given as needed.
labor, and immediately contraction, uterine either the mother  Oxytocin infusion should be discontinued
than 1-2 milliunits/min at
30-60 min intervals until following delivery. It hyper tonicity d/t or fetus favors immediately in the event of uterine
a contraction pattern stimulates rhythmic excessive dosage or surgical hyperactivity or fetal distress. Give O2 for
has been established contractions of the hypersensitivity to the intervention. the mother.
that is similar to labor.
uterus, increases the drug.
Rates exceeding 9-10
milliunits/min are rarely frequency of existing
required. contractions, and
 Control of postpartum raises the tone of
bleeding: Add 10-40
units (maximum of 40
uterine musculature.
units) to 1,000 ml of a
nonhydrating diluent and
run at a rate needed to
control uterine atony.
Treatment of
incomplete or inevitable
abortion: Infuse ten units
of oxytocin with 500 mL
physiological saline
solution or D5W in NSS
at a rate of 10-20
milliunits (20-40
drops/min). Do not
exceed 30 units in a 12-
hr period due to risk of
water intoxication.

2.Magnesium In the presence of

Sulfate Epsom Salts  Reserve IV use in eclampsia for
heart block or immediate control of life-threatening
Classification: It is an essential MagnesiumIntoxicatio myocardial convulsions. Give slowly to avoid producing
Anticonvulsant, element for muscle n: Cardiac & CNS damage. In hypermagnesemia.
Laxative and contraction, certain depression preceding toxemia or With premature labor, continually assess
Saline enzyme systems, and respiratory paralysis, pregnancy during fetal heart rate, intensity and timing of
contractions.
Dosage: nerve transmission. circulatory collapse, the 2 hr prior to
 Before administering IV check for the ff
 Seizures associated Extracellular fluid depressed reflexes, delivery. conditions:
with eclampsia: 10-14g. levels: 1.5-2.5 mEq/L. flaccid paralysis, - absent patellar reflexes
To initiate therapy, 4g flushing, hypotension,
Mg depresses the CNS - respirations below 16/min
MagSul in water for sweating. - urine output <100 ml in past 4 hr
injection or 4-5g in 250 and controls
CNS: Depression - early signs of hypermagnesemia:
ml of D5W or 0.9% NaCl convulsions by flushing, sweating, hypotensionm or
may be given IV. CV: Flushing,
blocking release of hypothermia.
 IV Infusion: hypotension, circulatory - Past history of heart block or
acetylcholine at the collapse, depression of
Hypomagnesemia, myocardial damage; prolonged PR and
severe: Adults: 5g myoneural junction, the myocardium. widened QRS intervals in ECG sheet.
(40mEq/L of D5W
injection of NaCl
injection by slow infusion
over period of 3 hrs. Use
caution to prevent
exceeding renal
excretory capacity.

3.