e

phrin
pine etic)
e
r
o
h
N
pat
(Sym iotensin
Ang II

Blood Flow

Na

secre
t.

Effe
rent Arteriole
d

Sympathetic (Norepi.)

ic)
Furosemide (loop diuret
blocks

reabsorbed (if not blocked)

25% of Na+ and 20% of K+

New HCO3- (if NH4+ excreted)

ANP Stimulated

ATP

Prostaglandins inhibit Na
reabsorption

Thick
Ascending
Limb
load-depend.
H2O imp.
Dilutes

hypertonic in loop of Henle b/c

water is leaving, solutes remain
Stimulated behind

Vasodilator
Vasoconstrictor
Major effect
Minor effect

insignificant, unless lots o stim.

H+

c.a.

ATP

CO2 + H2O

Principal Cell

Secrete K +
Add aquaporin2

Na
ADH

Cl -

AC

ADH promotes
urea
reabsorption
from INNER
MEDULLARY
collecting duct

Na

Aldosterone acts on distal and

collecting duct
1. Na reabsorption
2. potassium secretion
H+ secretion
Increased K+ plasma will
stimulate aldosterone secretion

H2O

Gs

K+

Thin Ascending Limb

H2O impermeable

ATP

H2O

ATP
cAMP
PKA

phosphoryln

ATP

Na+
K+

Aldosterone increases # of:

1. Na+ channels
2. Na+-K +-ATPase pumps
3. K + channels

Text

K -sparing diuretics ANP also blocks

(inhibit aldost. effect)

ADH (vasopressin) Stimulated

PTH

H2CO 3

New
HCO-3
absorbed

K+

Aldosterone Stimulated

Na + Most Mg2+
2 Cl paracellular
+
reabsorption
K

H+

(or H2 PO4 )

Angiotensin II Stimulated

HCO-3 + H+

here

K+

K+

NH +4

+
Na,
Cl

ATP

Na

(excreted)

Cl-

Na+

NH3 + H+

Cl Formate-

K+

2-

Prostaglandins
in CORTICAL
collecting duct inhibit Na
reabsorption

Reabsorb K
H excretion
Aldost. stimd
H 2 PO 4- excret.
NH 4+ excret.

(HPO4 or )

Na+

nd K+ reabsorbed

Late Proximal Tubule

Isosm. absorption

tazolamide)

CO 2 + H2 O

c.a. IV (blocked by ace

H 2 CO 3

Na + a

85% of reabsorbed HCO3- (if CO2 from tubule)

of

O3

CO 2+ H2 O

A-Intercalated

Cl -

AT
P

g Site

HC
carbonic
anhydrase II

Distal is Hypotonic

load-depend.
H20 imp.
Dilutes
NaCl abs.

Cl -

in
Tun

+
H 2CO 3

Early Distal
Tubule

Na+

ine

H
HCO -3 + H +

be
or
s
b
rea etics k
+
r c
A
of N
diu blo
e
5%
d
i
~
iaz
Th

67

Late Distal
Tubule &
Collecting Duct
A-Intercalated &
Principal Cells
H2O imp. w/o ADH
H2O permeable
with ADH

JGA

PTH

ATP

collecting duct

-F

Na

Na

~ 3% of NA
+r
ea
bs
or
Urodilantin in late distal and

ed

Na
s
id
Ac
o
in
Na ,
e
Am
at
ph or
os te,
Ph cta e,
la trat
ci

Na
e
os
uc
Gl

Fluid is iotonic in prox.

tubule

Early Proximal
Tubule
Isosm. abs.

ANP increases GFR by dilating afferent

and constricting efferent= increased
pressure, increased Na+ excretion

ANP

ATP

Phosphate,
Lactate, or
citrate

Afferent Arteriole

in
gland
Prosta ine
m
a
p
& Do

Amino
Acids

Glucose

Find an error?
email dkm2112@columbia.edu

Renin

PTH inhibits
phosphate
reabsorption

Nephron Schematic

od
blo

sympathetic works on afferent

angiotensin II works on efferent, first

ANP inhibits Na+

reabsorption in
MEDULLARY
collecting duct