Tonic seizures (frequency, 17-95%) - Can occur during wakefulness or sleep but are more frequent
during nonrapid eye movement (REM) sleep; may be axial, axiorhizomelic, or global; may be asymmetric
Atypical absence seizures (frequency, 17-100%) Can have gradual onset, with incomplete loss of
consciousness; associated eyelid myoclonias may be noted
Atonic, massive myoclonic, and myoclonic-atonic seizures (frequency, 10-56%) Can all cause a
sudden fall, producing injuries, or may be limited to the head falling on the chest; pure atonic seizures are
exceptional
Other types of seizures (generalized tonic-clonic [15%], complex partial [5%], absence status
epilepticus, tonic status epilepticus, nonconvulsive status epilepticus)
Findings on general physical examination are normal in many cases. No physical findings are pathognomonic
for LGS. Nevertheless, the general physical examination can help identify specific etiologies that have both
systemic and neurologic manifestations.
No neurologic examination findings are pathognomonic for LGS. However, neurologic examination of an LGS
patient may demonstrate the following:
Abnormalities in mental status function (specifically, deficits in higher cognitive function consistent with
intellectual disability)
Diagnosis
No laboratory investigations are known to aid in the diagnosis of LGS.
EEG (waking and sleep) is an essential part of the workup. Interictal EEG may demonstrate the following
characteristics:
Tonic seizure Diffuse, rapid, low-amplitude activity pattern that progressively decreases in frequency
and increases in amplitude; may be preceded by a brief generalized discharge of slow spike waves or
flattening of the recording or followed by diffuse slow waves and slow spike waves; no postictal flattening
Atypical absence seizure Diffuse, slow, and irregular spike waves; occasionally, discharges of rapid
rhythms preceded by flattening of the record for 1-2 seconds, followed by progressive development of
irregular fast rhythm in anterior and central regions and ending with brief spike waves
Atonic, massive myoclonic, or myoclonic-atonic seizure Slow spike waves, polyspike waves, or rapid
diffuse rhythms
Absence status epilepticus Continuous spike wave discharges, usually at a lower frequency than at
baseline, and rapid rhythms during tonic status epilepticus
Neuroimaging is an important part of the search for an underlying etiology. Modalities include the following:
Management
Medical treatment options may be divided into the following 3 major groups:
Corpus callosotomy Effective in reducing drop attacks but not typically helpful for other seizure types;
considered palliative rather than curative
Vagus nerve stimulation FDA-approved as adjunctive treatment for refractory partial-onset seizures
in adults and adolescents older than 12 years
Background
Childhood epileptic encephalopathy, or Lennox-Gastaut syndrome (LGS), is a devastating pediatric epilepsy
syndrome constituting 1-4% of childhood epilepsies. [1]The syndrome is characterized by multiple seizure types;
mental retardation or regression; and abnormal findings on electroencephalogram (EEG), with paroxysms of
fast activity and generalized slow spike-and-wave discharges (1.5-2 Hz).
The most common seizure types are tonic-axial, atonic, and absence seizures, but myoclonic, generalized
tonic-clonic, and partial seizures can be observed (see Clinical Presentation). An EEG is an essential part of
the workup for LGS. Neuroimaging is an important part of the search for an underlying etiology (see Workup).
A variety of therapeutic approaches are used in LGS, ranging from conventional antiepileptic agents to diet and
surgery (see Treatment and Management). Unfortunately, much of the evidence supporting these approaches
is not robust, and treatment is often ineffective.
See the following articles for more information:
Pathophysiology
The pathophysiology of LGS is not known. No animal models exist.
A variety of possible pathophysiologies have been proposed. One hypothesis states that excessive
permeability in the excitatory interhemispheric pathways in the frontal areas is present when the anterior parts
of the brain mature.
Involvement of immunogenetic mechanisms in triggering or maintaining some cases of LGS is hypothesized.
Although one study found a strong association between LGS and the human lymphocyte antigen class I
antigen B7, a second study did not. No clear-cut or homogeneous metabolic pattern was noted in 2 separate
reports of positron emission tomography (PET) studies in children with LGS.
Etiology
LGS can be classified according to its suspected etiology as either idiopathic or symptomatic. Patients may be
considered to have idiopathic LGS if normal psychomotor development occurred prior to the onset of
symptoms, no underlying disorders or definite presumptive causes are present, and no neurologic or
neuroradiologic abnormalities are found. In contrast, symptomatic LGS is diagnosed if a likely cause can be
identified as being responsible for the syndrome.
Population-based studies have found that 70-78% of patients with LGS have symptomatic LGS. Underlying
pathologies in these cases include the following:
Trauma
Infantile spasms precede the development of LGS in 9-39% of patients.
In addition to idiopathic and symptomatic LGS, some investigators add cryptogenic as a third etiologic
category.[2] This category encompasses cases in which the epilepsy appears to be symptomatic but a cause
cannot be identified. In an epidemiologic study in Atlanta, Georgia, 44% of patients with LGS were in the
cryptogenic group. In a series of 23 patients with cryptogenic LGS, 2.5-47.8% had a family history of epilepsy
and febrile seizures.
In 2001, the International League Against Epilepsy (ILAE) Task Force on Classification and Terminology
proposed to include LGS among the epileptic encephalopathies. These are conditions in which not only the
epileptic activity but also the epileptiform EEG abnormalities themselves are believed to contribute to the
progressive disturbance in cerebral function.[3]
Epidemiology
Overall, LGS accounts for 1-4% of patients with childhood epilepsy but 10% of patients with onset of epilepsy
when younger than 5 years. The prevalence of LGS in Atlanta, Georgia, was reported as 0.26 per 1000 live
births.
LGS is more common in boys than in girls. The prevalence is 0.1 per 1000 population for boys, versus 0.02 per
1000 population for girls (relative risk, 5.31).
The mean age at epilepsy onset is 26-28 months (range, 1 d to 14 y). The peak age at epilepsy onset is older
in patients with LGS of an identifiable etiology than in those whose LGS has no identifiable etiology. The
difference in age of onset between the group of patients with LGS and a history of West syndrome (infantile
spasm) and those with LGS without West syndrome is not significant. The average age at diagnosis of LGS in
Japan was 6 years (range, 2-15 y).
Epidemiologic studies in industrialized countries (eg, Israel, Spain, Estonia, Italy, Finland) have demonstrated
that the proportion of epileptic patients with LGS seems relatively consistent across the populations studied and
similar to that in the United States. The prevalence of LGS is 0.1-0.28 per 1000 population in Europe. The
annual incidence of LGS in childhood is approximately 2 per 100,000 children. [4]
Among children with intellectual disability, 7% have LGS, while 16.3% of institutionalized patients with
intellectual disability have LGS.
Prognosis
Long-term prognosis overall is unfavorable but variable in LGS. [5] Longitudinal studies have found that a minority
of patients with LGS eventually could work normally, but 47-76% still had typical characteristics (mental
retardation, treatment-resistant seizures) many years after onset and required significant help (eg, home care,
institutionalization).[6]
Patients with symptomatic LGS, particularly those with an early onset of seizures, prior history of West
syndrome, higher frequency of seizures, or constant slow EEG background activity, have a worse prognosis
than those with idiopathic seizures.
Tonic seizures may persist and be more difficult to control over time, while myoclonic and atypical absences
appear easier to control.
The characteristic diffuse slow spike wave pattern of LGS gradually disappears with age and is replaced by
focal epileptic discharges, especially multiple independent spikes.
Mortality rate is reported at 3% (mean follow-up period of 8.5 y) to 7% (mean follow-up period of 9.7 y). Death
often is related to accidents. A high rate of injuries is associated with atonic and/or tonic seizures.
The severity of the seizures, frequent injuries, developmental delays, and behavior problems take a large toll
on even the strongest parents and family structures. Pay attention to the psychosocial needs of the family
(especially siblings). The proper educational setting also is important to help the patient with LGS reach his or
her maximal potential.
Patient Education
Patients and their families need to be informed of the risk for the following severe idiosyncratic reactions from 3
commonly used antiepileptic medications for LGS:
History
Although approximately 20-30% of children with Lennox-Gastaut syndrome (LGS) are free from neurologic and
neuropsychologic deficits prior to onset of symptoms (ie, idiopathic LGS), these problems inevitably appear
during the evolution of LGS. Factors associated with more common or more severe mental retardation include
the following:
myoclonias or progressive flexion of the head secondary to a loss of tone. Automatisms may be observed.
Seizures may end gradually in some patients and abruptly in others.
Atonic seizures, massive myoclonic seizures, and myoclonic-atonic seizures have a frequency of 10-56% in
LGS. These seizures are difficult to differentiate by clinical observation only. Considerable discrepancies exist
in the use of these terms. All 3 types can produce a sudden fall, producing injuries (drop attacks, Sturzanflle)
or may be limited to the head falling on the chest (head drop, head nod, nictatio capitis). Pure atonic seizures
are exceptional; most have a tonic or myoclonic component.
Other types of seizures are noted. Generalized tonic-clonic seizures are reported in 15% of patients, while
complex partial seizures occur in 5%. Absence status epilepticus, tonic status epilepticus, and nonconvulsive
status epilepticus all can occur, can have a long duration, and can be resistant to therapy.
Physical Examination
Findings on general physical examination are normal in many patients with LGS. There are no physical findings
pathognomonic for LGS.
Nevertheless, the general physical examination can be important in helping to identify specific etiologies that
have both systemic and neurologic manifestations (eg, adenoma sebaceum or ash leaf macules in tuberous
sclerosis). Use a Wood lamp to examine the skin. Patients may exhibit moderately severe to severe growth
delay, a nonspecific finding that is more a reflection of the underlying brain injury than of a specific epilepsy
syndrome.
Neurologic examination
Neurologic examination in patients with LGS demonstrates abnormalities in mental status function, specifically
deficits in higher cognitive function consistent with intellectual disability.
Abnormalities in level of consciousness, cranial nerve function, motor/sensory/reflex examination, cerebellar
testing, or gait are nonspecific findings and more a reflection of the underlying brain injury or effect of
anticonvulsant medications. No neurologic examination findings are pathognomonic for LGS.
Complications
Potential complications of LGS include death (either sudden unexplained death in epilepsy or related to an
accident involving a seizure) and injuries (especially facial) from seizures resulting in falls.
Approach Considerations
Electroencephalography (EEG) is an essential part of the workup for Lennox-Gastaut syndrome (LGS). To
date, there are no known laboratory investigations to aid in the diagnosis of LGS. Neuroimaging is an important
part of the search for an underlying etiology in a patient with LGS.
Electroencephalography
Always perform an EEG in patients with suspected LGS, since the diagnosis depends on the presence of
specific EEG findings. A routine 20-minute EEG may not capture the patient both awake and asleep and thus
may miss specific important EEG findings. Instead, obtain prolonged video/EEG telemetry, if possible. Record
both waking and sleep EEG, to assist in confirming a suspected diagnosis and to capture and classify each of
the patient's multiple seizure types.
Video recordings can also be used to educate the parents on which of the patient's "events" are seizures and
which are nonepileptic behavioral events. Parental ability to correctly recognize and identify atypical absences
is poor. In one study using video/EEG monitoring in a cohort of children with LGS, parental recognition was
27% for atypical absences, while the sensitivity was as high as 80% for myoclonic seizures and 100% for tonic,
atonic, tonic-clonic, clonic, and complex partial seizures. [7]
Go to EEG in Common Epilepsy Syndromes, Epileptiform Normal Variants on EEG, andGeneralized Epilepsies
on EEG for more information on these topics.
Interictal electroencephalography
Interictal EEG is characterized by a slow background that can be constant or transient. Permanent slowing of
the background is associated with poor cognitive prognosis.
The hallmark of the awake interictal EEG in patients with LGS is the diffuse slow spike wave (see the image
below). This pattern consists of bursts of irregular and generalized spikes or sharp waves followed by a
sinusoidal 35-400-millisecond slow wave with an amplitude of 200-800 microvolts, which can be symmetric or
asymmetric.
The amplitude often is higher in the anterior region or in the frontal or frontocentral areas, but in some patients
the activity may dominate in the posterior head regions. The frequency of the slow spike wave activity
commonly is found at 1.5-2.5 Hz.
Slow spike waves usually are not activated by photic stimulation. Hyperventilation rarely induces slow spike
waves, although mental retardation prevents adequate cooperation in many patients. During nonrapid eye
movement (REM) sleep, discharges are more generalized, more frequent, and consist of polyspikes and slow
waves. In REM sleep, spike waves decrease. During periods of frequent seizures, the total duration of REM
sleep is reduced.
Ictal electroencephalography
During a tonic seizure, the EEG is characterized by a diffuse, rapid (10-13 Hz), low-amplitude activity pattern,
mainly in the anterior and vertex areas ("recruiting rhythm") that progressively decreases in frequency and
increases in amplitude.
A brief generalized discharge of slow spike waves or flattening of the recording may precede this pattern.
Diffuse slow waves and slow spike waves may follow it.
These fast discharges are common during non-REM sleep. Unlike tonic-clonic seizures, no postictal flattening
occurs with these seizures. Clinical manifestations appear 0.5-1 second after the onset of EEG manifestations
and last several seconds longer than the discharge.
During an atypical absence seizure, the EEG is characterized by diffuse, slow (2-2.5 Hz), and irregular spike
waves, which may be difficult to differentiate from interictal bursts. Occasionally, discharges of rapid rhythms
may be observed preceded by flattening of the record for 1-2 seconds, followed by progressive development of
irregular fast rhythm in the anterior and central regions, and ending with brief spike waves.
During atonic, massive myoclonic, and myoclonic-atonic seizures, the EEG is characterized by slow spike
waves, polyspike waves, or rapid diffuse rhythms. Simultaneous video/EEG recording can help differentiate
these seizure types. In most patients, these 3 types of seizures coexist.
The EEG during absence status epilepticus reveals continuous spike wave discharges, usually at a lower
frequency than at baseline, and rapid rhythms during tonic status epilepticus.
Neuroimaging Studies
In general, a magnetic resonance imaging (MRI) scan is the preferred neuroimaging study for a patient with
LGS, rather than a CT scan. CT scans may be preferred in selected situations (eg, evaluation of suspected
intracranial injury and/or hematoma in a patient with head trauma resulting from a seizure).
Abnormalities revealed by neuroimaging associated with LGS include tuberous sclerosis, brain malformations
(eg, cortical dysplasias), hypoxia-ischemia injury, or frontal lobe lesions.
No current indication exists for routine positron emission tomography (PET) or single-photon emission
computed tomography (SPECT) scanning in patients with LGS. However, PET or SPECT scans may be useful
in patients undergoing evaluation as candidates for epilepsy surgery.
Approach Considerations
The goals of treatment for patients with Lennox-Gastaut syndrome (LGS) are the same as for all patients with
epilepsy: the best quality of life with the fewest seizures (ideally, none), the fewest adverse treatment effects,
and the least number of medications.
A variety of therapeutic approaches are used in LGS, ranging from conventional antiepileptic agents to diet and
surgery. Unfortunately, much of the evidence supporting these approaches is not robust, and treatment is often
ineffective.[8, 9]
The medical treatment options for patients with LGS can be divided into the following 3 major groups:
First-line treatments based on clinical experience or conventional wisdom (eg, valproic acid,
benzodiazepines [specifically clonazepam, nitrazepam, clobazam [10, 11, 12] ])
Treatments suspected to be effective on the basis of open-label uncontrolled studies (eg,
vigabatrin, [13] zonisamide [14] )
Antiepileptic Therapy
Antiepileptic drugs (AEDs) are the mainstay of therapy for patients with LGS. Unfortunately, no one AED gives
satisfactory relief for all or even most patients with LGS. A combination of agents frequently is required.
Patients with LGS experience frequent exacerbations of their seizures that may require inpatient adjustment of
AEDs.
Patients with LGS have a recognized high risk for status epilepticus. Because of the consequent risk of injury or
death, a medication for emergency intervention (eg, rectal diazepam) should be prescribed.
Valproate
Valproate (Depakote, Depakene, Depacon) has been considered the first-line treatment option for children with
LGS for the past 2 decades. It is reported to be more effective in patients with cryptogenic LGS than in those
with symptomatic LGS.
Lamotrigine
The efficacy of lamotrigine (Lamictal) as adjunctive therapy against seizures associated with LGS was
demonstrated in 2 controlled trials and multiple open-label studies. This agent is valuable for patients with LGS,
despite its risk of idiosyncratic dermatologic reactions, and its use should be considered as soon as diagnosis
of LGS is made. Proper attention to concomitant medications, low starting dose, and very slow titration can
minimize the risk of dermatologic reactions.
Topiramate
In a multicenter, double-blind, placebo-controlled trial, topiramate (Topamax) was found to be safe and effective
as adjunctive therapy for patients with LGS.[18] The target dose was 6 mg/kg/d. In a long-term open-label
extension portion of this trial (mean dosage 10 mg/kg/d), drop attacks were reduced by greater than half in 55%
of patients, and 15% of patients were free of drop attacks for over 6 mo at the last visit. [17]
Felbamate
Felbamate (Felbatol) was found to be safe and effective in patients with LGS in a randomized, double-blind,
placebo-controlled adjunctive therapy trial, and 12-month follow-up in patients who completed controlled part of
study confirmed long-term efficacy.[19] Despite the efficacy of felbamate, the significant risk of idiosyncratic
reactions associated with its use make it a third-line or fourth-line drug for LGS.
Zonisamide
The effectiveness of zonisamide (Zonegran) in LGS has been investigated in 3 small open-label studies, with
promising results. A multicenter study of zonisamide for long-term adjunctive therapy in 62 children with LGS
found that it was safe and effective; 4.8% of children had 100% seizure freedom, and 22.6% had >75%
reduction in their seizures, independent of seizure type.[14]
Vigabatrin (Sabril)
Vigabatrin (Sabril) was approved by the US Food and Drug Administration (FDA) in 2009 as monotherapy for
infantile spasms in patients 1 month to 2 years old, and as adjunctive therapy for adults with refractory complex
partial seizures. In 6 open-label studies involving 78 patients with LGS, 15% became completely seizure free
and 44% had a >50% reduction in seizure frequency.[24]
Rufinamide
The FDA approved rufinamide (Banzel) in 2008 for the adjunctive treatment of seizures associated with LGS in
children 4 years and older and adults. In a double-blind, randomized, placebo-controlled trial by Glauser et al,
rufinamide produced a statistically significant decrease in total seizure frequency and tonic-atonic seizures in
individuals aged 4-30 years.[20] A 2009 open-label European study also demonstrated decreased seizure
frequency amongst those with LGS.[21]
In a multicenter clinical trial of 59 patients with LGS, rufinamide was found to decrease the frequency of tonicatonic seizures by 24.2%, versus 3.3% with placebo, and total seizures by 32.9%, versus 3.3% with placebo.
Adverse events in the rufinamide group included decreased appetite (17.2%), somnolence (17.2%), and
vomiting (13.8%).[25]
In February 2015, rufinamide was approved in pediatric patients aged 1 to 4 years based on a pharmacokinetic
bridging study of a Phase III clinical trial which demonstrated the pharmacokinetic and safety profiles are
consistent with those seen in ages 4 years.[34]
Benzodiazepines
Clonazepam (Klonopin) is considered an effective first-line AED therapy for seizures associated with LGS.
However, the adverse effects and development of tolerance limit its usefulness over time. Dosing on an everyother-day schedule or alternating 2 benzodiazepines daily may slow development of tolerance. The
benzodiazepine clobazam, which is widely used as an anticonvulsant in other countries, was approved by the
FDA in October 2011.[12] The combination of valproic acid and a benzodiazepine may be better than either drug
alone.
In the CONTAIN study of patients with LGS given clobazam, more than 50% of patients had a 50% or greater
decrease in weekly drop- and total-seizure frequency. The percentage of patients achieving 100% reduction in
drop seizures was 33% for clobazam-treated patients (vs. 7% for placebo) in Quartile 1 (least severe LGS), and
5% of clobazam-treated patients in Quartile 4 (most severe LGS) achieved 100% reduction in drop seizures,
versus 0% for placebo.[26]
In a second study (OLE study), through 5 years of clobazam therapy, more than 50% of patients in all 4
quartiles (least severe to most severe LGS) demonstrated a decrease of 50% or more in weekly frequency for
drop seizures. More than 12% of patients in Quartile 4 achieved 100% reduction in drop seizures from month 3
through year 5.[26]
The FDA has issued a warning that clobazam, used as add-on therapy to treat seizures in patients with LGS,
may trigger Stevens-Johnson syndrome and toxic epidermal necrolysis, rare but potentially fatal cutaneous
reactions.[27, 28] The risk of developing these disorders is increased during the first 8 weeks of treatment or when
treatment is resumed after it is discontinued.
Corpus Callostomy
Corpus callosotomy is effective in reducing drop attacks but is typically not helpful for other seizure types. It is
considered palliative rather than curative. Seizure freedom following corpus callosotomy is rare but can occur.
A 2006 study showed a greater than 90% seizure reduction in 52 of 76 patients with LGS who underwent an
extended, one-stage, callosal section (splenium intact); 7 of the 76 patients were seizure free. [29] The mean
follow-up time was 4.7 years. The seizure types most responsive to surgery were atonic and atypical absence.
Ketogenic Diet
The ketogenic diet comprises a high ratio of fats (ketogenic foods) to proteins and carbohydrates (antiketogenic
foods). The ratio of ketogenic to antiketogenic foods in the diet ranges from 2:1 to 4:1 or higher. In general, the
benefits of the diet for people with epilepsy include fewer seizures, less drowsiness, better behavior, and need
for fewer concomitant AEDs.
Based on multiple open-label and, most recently, randomized controlled studies, the ketogenic diet appears to
be a useful therapy for patients with LGS. Efficacy appears greatest for atonic, myoclonic, and atypical absence
seizures, but other seizure types (tonic-clonic, secondarily generalized tonic-clonic) may also respond.
In a 2008 randomized controlled trial of the ketogenic diet in children with daily seizures who had a poor
response to at least 2 AEDs, 38% of the children in the diet arm had a greater than 50% reduction in seizures.
Of the 145 children randomized to the ketogenic diet or control, only 14 had LGS. [31]
A blinded, crossover study of the ketogenic diet in 20 children with LGS showed a moderate reduction in
parent-reported myoclonic-atonic events. Ketosis was not eliminated in the placebo arm; thus, there was no
difference observed between the 2 groups regarding reduction in EEG-identified events. When patients who
are seizure free for extended periods of time should be weaned from the diet is not clear.[32]
The ketogenic diet is not always successful. The following 3 factors are associated with successful
implementation of the diet:
Injury Prevention
Some patients with LGS wear protective helmets with face guards to maximize protection of the forehead,
nose, and teeth (see the image below). Unfortunately, some patients with LGS do not tolerate the helmet with
face guards, and even if tolerated, helmets often are uncomfortable and rarely are cosmetically acceptable.
Consultations
Pediatric neuropsychologists can assess intellectual function and educational needs and advise on
nonpharmacologic management of behavioral problems. Pediatric psychiatrists can advise on pharmacologic
management of behavioral problems. Neurosurgeons can assist in the placement of a vagus nerve stimulator
and assess the patient as a candidate for corpus callosotomy or focal resection. Dietitians can assist in the
institution and maintenance of the ketogenic diet.
Medication Summary
The goals of pharmacotherapy in Lennox-Gastaut syndrome (LGS) are to reduce morbidity and prevent
complications. Pharmacotherapeutic agents used in such patients include anticonvulsants and
benzodiazepines.
Anticonvulsants
Class Summary
These agents prevent seizure recurrence and terminate clinical and electrical seizure activity.
View full drug information
Topiramate (Topamax)
Topiramate has been found to be safe and effective as adjunctive therapy (target dose 6 mg/kg/d) for patients
with LGS.
View full drug information
Felbamate (Felbatol)
Felbamate has been found to be safe and effective in patients with LGS. However the significant risk of
idiosyncratic reactions associated with its use make it a third-line or fourth-line drug for LGS.
View full drug information
Zonisamide (Zonegran)
Zonisamide is effective as long-term adjunctive therapy in children with LGS.
View full drug information
Vigabatrin (Sabril)
Vigabatrin was approved by US Food and Drug Administration (FDA) in 2009 as monotherapy for patients with
infantile spasms aged 1 month to 2 years and as adjunctive therapy for adults with refractory complex partial
seizures.
View full drug information
Rufinamide (Banzel)
An antiepileptic agent that is structurally unrelated to current antiepileptics, rufinamide modulates sodium
channel activity, particularly prolongation of the channel's inactive state. It significantly slows sodium channel
recovery and limits sustained repetitive firing of sodium-dependent action potentials. It is indicated for
adjunctive therapy in adults and children aged 1 year or older with seizures associated with LGS.
Benzodiazepines
Class Summary
By binding to specific receptor-sites, these agents appear to potentiate the effects of gamma-aminobutyrate
(GABA) and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters.
View full drug information
Clonazepam (Klonopin)
Clonazepam is considered an effective first-line AED therapy for seizures associated with LGS. Adverse effects
and development of tolerance limit usefulness over time; dosing on an every-other-day schedule or alternating
2 benzodiazepines daily may slow development of tolerance. The benzodiazepine nitrazepam (Mogadon) is not
approved by FDA but is available in many countries. The combination of valproic acid and a benzodiazepine
may be better than either drug alone.
View full drug information
Clobazam (ONFI)
1,5-benzodiazepine that possesses potent anticonvulsant properties. Exact mechanism of action is not fully
understood; thought to potentiate GABAergic neurotransmission resulting from binding to GABA-A receptor.
The active metabolite, N-demethylclobazam, is largely responsible for its long duration of action. It is indicated
for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients older than 2
years.