Anastrozole
Bleomycin
Busulfan
Carmustine
Cisplatin
Cyclophosphamide
Doxorubicin
Etoposide
Fluorouracil
Gemtuzumab ozogamicin
Imatinib
Leuprolide
Meraptopurine
Methotrexate
Paclitaxel
Tamoxifen
Trastuzumab
Vincristine
Anastrozole
Estrogen antagonist
Nonsteroidal aromatase
inhibitor
Breast cancer in
postmenopausal women
N
HA
Hot flashes
Back pain
Bleomycin
Antitumor
DNA intercalating
Complexes iron-forming
oxygen free radicals that
cause single strand breaks
G2 phase specific
Lymphomas
SCC
Testicular carcinoma
Choriocarcinoma
Busulfan
Antineoplastic
Alkyl sulfonate bifunctional
alkylating agent
Cross-links DNA strands by
covalently bonding guanine
residues
Prevents DNA replication &
transcription
CML
N, V
Myelosuppression
Pulmonary fibrosis
Carmustine
Antineoplastic
Nitrosurea bifunctional
akylating agent
Brain tumors
Myeloma
Lymphoma
Causes prolonged
myelosuppression
N, V
Hepatotoxicity
Anemia
Leucopenia
Thrombocytopenia
Pulmonary fibrosis
Cisplatin
Antineoplastic
Platinum compound
Severe N, V
Ototoxicity & tinnitus
Hypocalcemia
Hypokalemia
Hypomagnesemia
Anemia
Cyclophosphamide
Antineoplastic
Nitrogen mustard bifunctional
akylating agent
Anorexia
N, V
Hemorrhagic cystitis & hematuria
Alopecia
Thrombocytopenia
Leukopenia
Anemia
Hodgkins ds
Lymphomas, myeloma
Leukemia
Ovarian & breast tumors
RA
Converted to active metabolites by CYP
enzymes
Doxorubicin
Antitumor
DNA intercalating agent
Inserts b/w DNA bases
Cardiomyopathy dose-limiting
Anemia
Leukopenia
Thrombocytopenia
Diarrhea
V
Stomatitis
Alopecia
S phase specific
Etoposide
Antineoplastic
Podophyllotoxin,
topoisomerase inhibitor
Inhibits mammalian
topoisomerase II & prevents
resealing of nicked DNA
strands
G2 phase specific
N, V
Leukopenia
Thrombocytopenia
Alopecia
Fluorouracil
Antineoplastic
Pyrimidine antimetabolite
Converted to active
nucleotide form
Inhibits thymidylate
synthetase
S phase specific
Diarrhea
V
Stomatitis
Alopecia
Maculopapular rash
Anemia
Leukopenia
Thrombocytopenia
Gemtuzumab ozogamicin
Antineoplastic
Monoclonal Ab & cytotoxic
ABX calicheamicin
Gemtuzumab
Binds CD33 Ag on
hematopoietic cells & sequesters
lysosomes where calicheamicin
is released
Calicheamicin
anaphylaxis
Imatinib
Antineoplastic
Tyrosine kinase inhibitor
CML
Cough
Dyspnea
Pharyngitis
Pneumonia
Abdominal pain
V
Petechiae
Pruritis
Rash
Night sweats
Myalgia
Arthralgia
Thrombocytopenia
Neutropenia
Leuprolide
Hot flashes
Mercaptopurine
Antineoplastic
Purine antimetabolite
Converted to nucleotide triphosphate
by phosphoribosyl transferase
Inhibits purine biosynthesis &
salvage pathways
S phase specific
Acute leukemia
CML
Lymphomas
Tumors that delete phosphoribosyltransferase acquire resistance
Cross-react w/ thioguanine
Myelosuppression
Hyperuricemia
Hepatotoxicity
Methotrexate
Antineoplastic
Folate reductase inhibitor
N, V
Stomatitis
Hepatotoxicity
Anemia
Leukopenia
Thrombocytopenia
Nephropathy
Paclitaxel
Antineoplastic
Mitotic inhibitor
D
N, V
Alopecia
Anemia
Leukopenia
Thrombocytopenia
Peripheral neuropathy
Arthralgia
Myalgia
Tamoxifen
Antineoplastic
Estrogen receptor antagonist
& partial agonist
Competes w/ estrogen for
receptors in breast & other
tissues
Suppresses breast tumor
growth
N
Hot flashes
Menstrual irregularities
Trastuzumab
Antineoplastic
Monoclonal Ab
Combined w/ paclitaxel
blood levels
Abdominal pain
Anorexia
Diarrhea
V
Back pain
Chills
Fever
Allergic rxns
Doxorubicin risk of
cardiotoxicity
Vincristine
Antineoplastic
Vinca alkaloid, mitotic inhibitor
Hodgkins ds
Lymphoma
Leukemia
Neuroblastoma
Rhabdomyosarcoma
Wilms tumor
N, V
Alopecia
Peripheral neuropathy