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Using silver nanoparticles, researchers create cream that avoids

transmission of HIV
Date: January 28, 2014

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Source: Investigacin y Desarrollo

Summary: After discovering that silver nanoparticles are capable of blocking the
entry of HIV into organisms, a group of researchers created a vaginal
cream to control the transmission of the virus. The product has proven
efficiency in lab tests, although clinical trials are yet to be performed.

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Silver nanoparticles.
Credit: Investigacin y Desarrollo

[Click to enlarge image]

fter discovering that silver nanoparticles are capable of blocking the

entry of Human Immunodeficiency Virus (HIV) into the organism, a
group of researchers from the University of Texas, in collaboration
with Humberto Lara Villegas, specialist in nanoparticles and virology from
the University of Monterrey, Mexico (UDEM), create a vaginal cream to
control the transmission of the virus.

Lara Villegas explained that HIV makes its entry to

immune cells (CD4) of the organism with the aid of a
protein known as GP120, which allows the virus
adherence to the cells. This same principle is used by
silver nanoparticles to attach themselves to this protein
and block it, turning the virus inactive.
The Mexican researcher informed that the cream has been
tested in samples of human tissue and has proven the
efficiency of silver nanoparticles to avoid the transmission
of the virus through cervical mucous membrane.
The researcher from UDEM, who has worked in Israel and The United States, assured
that after applied, the cream starts to work in less than a minute, and has an effective
protection of up to 72 hours.
Given that the function of this product is the inactivation of the virus, although this is a
vaginal cream, will also protect the sexual partner.
"Normally -- he highlighted-, the medication used against the virus act within the cell to
avoid its replication. This is a very different case, given that the nanoparticle goes
directly against the HIV and no longer allows its entry to the cell."
So far, no toxicity of the silver nanoparticles has been reported, although he added
that research is yet to be performed to evaluate the possible side effects of silver
properties.
"Right now, I am certain that this microbicide is going to avoid the virus entering the
organism, but I cannot yet assure that is totally harmless, because the clinical trials are
a long and expensive process," the researched added.
He exposed that the use of gels are usually accompanied by irritation, which favors the
entry of the virus, which is why the cream was enriched with an anti-inflammatory
effect.
Currently, with the obtained results, researchers will proceed to perform
experimentation in mice that accept human cells, to later begin with human clinical
trials.
He added that this cream could prevent the transmission of other sexually acquired
virus like the Human Papilloma Virus (HPV). Likewise, he considered that silver
nanoparticles could be used to combat bacteria transmitted the same way.
He forwarded that his research team is working in a diagnosis kit that predicts within
hours, through blood tests, the resistance of a seropositive person to antiretroviral
treatment, results that will help the physician to prescribe the most adequate treatment
to the person that lives with HIV.

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"Currently we can give this results but we are working in preliminary tests and require
to study a lot of seropositive patients to calibrate this kit," he concluded.

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Investigacin y Desarrollo. "Using silver nanoparticles, researchers create cream

that avoids transmission of HIV." ScienceDaily. ScienceDaily, 28 January 2014.
<www.sciencedaily.com/releases/2014/01/140128094328.htm>.

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