ABSTRACT
Background: Urinary tract infections are common among menopausal women and most of them will develop
recurrence. The Prevalence is increasing with age. The use of antibiotics as therapy increases resistence risk of therapy.
The affordable antibiotics, inexpensive, safe and effective are needed to find. By using In-vitro, ginger effectively inhibit
growth of isolate uropathogenic Escherichia coli.
Objective: The aim of this study is to prove the effect of ginger in the Uropathogenic Escherichia Coli Colonies in
menopausal women.
Methode: A pra-experimental study with one group pre test-post test design. Ginger with a similar variety and age is
turned into a powder capsule. The subject of the research is patient in the geriatric and menopause outpatient clinic
Dr.Soetomo Central Hospital-Surabaya. Each subject taken ginger powder for five days in row. Midstream clean catch
urine was performed before and after the treatment in order to identify and count the colony of Escherichia coli.
Result: : 12 out of 52 participants had a positive Uropathogenic Escherichia coli result from the culture before treatment.
5 subjec had colony count 105cfu/ml and 7 subjec <10 5cfu/ml. 11 subject shows a negative result and 1 subject still had
a positive result although a number of colony is decrease (10 4cfu/ml become 2x103cfu/ml). There is significant result of
the decrease of the colony calculation as a result of consume ginger powder capsule, p=0,001 (p<0,05).
Conclusion: Ginger decrease a number of Escherichia coli colony in menopausal women.
Keywords: Ginger, Menopause, Uropathogenic Eschericha coli
Correspondence: Dony Rosmana Bimantara, Departemen/SMF Obstetric & Gynecology, Faculty of Medicine Airlangga
University
Dr. Soetomo Center Hospital, Surabaya, East Java, Indonesia, Call: +6281803215579, Email:
donyrosmana@yahoo.com
Background
Urinary tract infection (UTI) is a bacterial
infection that commonly occurs in young women and
the elderly and often causes recurrence. UTI is still
often posing serious problems chiefly related to
nosocomial infections, high recurrent morbidity rate,
and high cost treatment impact. UTIs in older women
was associated with an average of high mortality,
although in some cases of asymptomatic UTI, it was is
not the cause of death(1,2,3,4).
The risk of UTI in women during their lifetime
can be more than 50%, which the prevalence of
bacteriuria was increased by age. In the epidemiological
research, it was found a 15% -20% prevalence of
bacteriuria in women aged 65-70 years and 20% -50%
prevalence in women aged >80 years(1,2,3,5).
Factors that play a role in the pathogenesis of
UTI namely: host, and the host defense mechanisms of
bacterial virulence factors. Host factor differs between
men and women. Due to the anatomical conditions in
women, instrumentation measures during pregnancy
and the menopause condition, women were more
vulnerable to infection. Defense mechanism of the body
Because ginger has been used as antiinflammatory therapy in humans, we conducted in-vivo
studies in humans related to ginger as an antibacterial
activity that has not been done in other studies.
Age
50
63
55.58 ( 3.98)
108
137
123.58 ( 11.11)
Hemoglobin
11.7
14.20
13.0 ( 0.67)
1.006
1.022
1.0144 (
0.005)
Length of menopause
10
4.83 ( 3.40)
21.10
24.60
22.991 ( 1.14)
Variables
Frequency of
urination before
administration
12
9.792 (0.950)
Frequency of
urination after
administration
12
10.783 ( 0.76)
Urine volume
before
administration of
ginger capsules
12
1218.96 (223.78)
Urine volume
after
administration
12
1168.25 ( 73.81)
Variables
Education
Job
Parity
Min
Max
Mean (SD)
Mean (SD)
Variables
Numbe
Frequency
Percentage
Elementary
8.3%
Junior high
41.7%
Senior high
25%
Bachelor
25%
Housewife
50%
Civil servant
33.3%
Private
worker
16.7%
Primi
8.3%
Sexual
intercourse
Rinsing
Habits
Multi
11
91.7%
16.7%
25%
8.3%
50%
Back to front
25%
Front to back
75%
Stomach
feels the
heat
Yes
58.3%
No
41.7%
A sense of
palpitations
Yes
25%
No
75%
Yes
75%
No
25%
Warm
feeling in
Body
administratio
n
Escherichia
coli
(cfu/ml)
10000
1000000
11000
9000
1000000
6000
60000
1000000
36000
47000
1000000
1000000
Result
Positive
12
Mean
Rank
0,00
Negative
Positive
0
1
6,00
Negative
11
* Significant if p <0.05
Urine culture
after the
2000
Number
Nilai p
0,001*
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