Rx
Ibuprofen
Gelot 64
Labrafil M 1944
Octyldodecyl myristate
Sodium methylparaben
Sorbic acid
Stearic acid
Ethoxydiglycol
Lavender oil
Purified water
qs
For 100
5
24
5
3
70
30
1
15
0.15
100
mL
g
g
g
g
mg
mg
g
mL
mL
mL
METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total
amount to be prepared.
2. Weigh and/or measure each ingredient accurately.
3. Place about 45 mL of purified water in a suitable container and heat
to 80C.
4. Stir in the Gelot 64, Labrafil M 1944, octyldodecyl myristate, sodium
methylparaben, sorbic acid, and stearic acid and mix well.
5. Homogenize briefly and cool to room temperature.
6. Add the ibuprofen to the ethoxydiglycol separately and add the lavender oil; then add to the vehicle and mix thoroughly.
7. Add sufficient purified water to final volume and mix well.
8. Package and label.
PACKAGING
Keep out of reach of children. Use only as directed. For external use only.
Lavender oil is the volatile oil distilled with steam from the fresh flowering tops of Lavandula officinalis Chaix ex Villars. It occurs as a colorless or
yellow liquid, with the characteristic odor and taste of lavender flowers. It
has a specific gravity of 0.875 to 0.888. It is soluble 1 volume in 4 volumes
of 70% alcohol.7
STABILITY
REFERENCES
LABELING
USE
This preparation is used as a topical anti-inflammatory agent.
QUALITY CONTROL
Quality-control assessment can include theoretical weight compared
to actual weight, pH, specific gravity, active drug assay, color, texturesurface, texture-spatula spread, appearance, feel, rheological properties,
and physical observations.2
DISCUSSION
Ibuprofen (C13H18O2, MW 206.28) is a nonsteroidal anti-inflammatory
agent with analgesic and antipyretic activity. It occurs as a white to offwhite, crystalline powder with a slight, characteristic odor. It is practically
insoluble in water but very soluble in alcohol and acetone.
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