Shane Spiers
shanespiers@mail.usf.edu
U07078824
Biomedical Sciences
Thesis Director: Dr. Mark Jaroszeski
Prospectus
Oncology. Many cancer cells secrete a PD1 ligand that binds to PD1 receptors
on T-cells causing them to be driven into apoptosis. Cancer-derived
antibodies are able to neutralize the PD1 ligand, which is no longer able to
bind to the PD1 receptor and the T-cells are still able to function. Ketruda
(pembrolizumab) is an anti-PD1 antibody that has been released by Merck &
Co. for stage 3 metastatic melanoma, the 3 rd deadliest cancer in the US. The
Hedgehog Pathway is a major regulator of fundamental processes in the
body such as coordinating cell growth and development, and is currently
being studied as a means of medulloblastoma treatment (Huang, 2015). We
can also see that the research being done into vascular endothelial growth
factors, which are directly involved in immunosuppression and angiogenesis
in tumor biology, prove as potential for new therapy (Johnson, 2007).
Cancer patients are ostensibly noticed getting smaller as prognosis
continues. Many are under the impression that this is due to the effect of
cancer eating away at the body, however in actuality it is due to starvation
of healthy regions of the body by the cancerous cells. This is a booming area
of research where biologics and genes are now being used to attack those
genes and cancers. If you could take a biopsy of a tumor and conduct a gene
assay on the sample, we can find mutations and design a gene, drug or
antibody. Chemotherapy has been a popular reaction to the discovery of
cancer in a body, but it is actually a means of supplying enough poison that
doesnt kill the entire body. The process by which chemotherapy operates
does not directly target anything, and many times it can result in the
development
of
cancerous
cells
through
ingestion
of
carcinogenic
compounds in the treatment. We can see that the modulation of our immune
system can be the perfect vehicle for destroying tumor cells (Bustamante
Alvarez, 2015). The problem is that we need to develop a technique to train
the immune system to carry out the appropriate response. Though gene
therapy at the cell-response level can potentially be used to treat cancer,
most pre-existing research on the subject has been derived from animal
research and clinical trials.
Cancer is notoriously known for inducing a change in a persons diet.
As such, it may not be farfetched to suggest dietary modifications and
alternative medicine as a means of curing the aforementioned disease.
Ketogenic, paleo, low-sugar and organic diets have been anecdotally known
to positively contribute to the treatment of certain types of cancer (Hao et al,
2015). This stems from the fact that cancer cells metabolize these materials
and induce the activity of the cancer. As mentioned previously, tumorigenic
cells starve the body of nutrients in order to thrive, so to determine a way in
which you can starve the body of the nutrients which the cancer cells need
while keeping the rest of the body of the patient fully functional can be a
potential solution (Kapelner & Vorsanger, 2015).
Combination therapies (multi-faceted treatments comprising the use of
chemotherapy, antibodies, radiation, modulation of the immune system and
gene therapy) are proposed to be the most effective means of treatment of
the disease. Etoposide plus radiation therapy followed by combination
chemotherapy has been one recently tested treatment in children with newly
diagnosed advanced medulloblastoma (Childrens Oncology Group, 2014).
Despite aggressive treatment involving surgery, chemotherapy, radiation
and other therapies, most patients suffer devastating side effects. Thus, the
development of new treatment strategies is urgently needed. The focus of
this study will be to compile past and current information and potentially
determine the best means by which medulloblastoma could be treated given
recent advances that have been made within the field of oncology.
Works Cited
Advanced
Medulloblastoma.
2000-
[cited
October
20 th
2015].
of
Available
https://www.clinicaltrials.gov/ct2/show/NCT00003573
NLM
In:
Medicine
from:
Identifier:
NCT00003573.
Hao, G. W., et al. "Growth of Human Colon Cancer Cells in Nude Mice Is
Delayed by Ketogenic Diet with or without Omega-3 Fatty Acids and
Medium-Chain Triglycerides." Asian Pac J Cancer Prev 16.5 (2015):
2061-8. Print.
Johnson,
B.
F.,
et
al.
"Vascular
Endothelial
Growth
Factor
and
Word Count