FLAVONOIDES EXCELENTE
Mecanismos prooxidantes
Debido a las caractersticas estructurales de algunos
flavonoides, como las antocianidinas, provocan bajos
potenciales de oxidacin (EP/2), que les permite reducir
el Fe3+ y el Cu2+ para sufrir una autooxidacin o incluso
involucrarse en un proceso de reciclaje redox, actuando
de esta manera como agentes prooxidantes, lo
que explica los efectos mutagnicos y genotxicos de
algunos flavonoides.18
Algunos de estos mecanismos incluyen la reduccin temporal
de Cu (II) a CU (I), la autooxidacin del radical aroxilo
generando anin superxido (O2-) que siguiendo su secuencia
general el daino radical hidroxilo (HO.), as como la
afeccin de las funciones de los componentes del sistema de
defensa antioxidante nuclear: glutatin y glutatin-S-transferasa.
19
http://metabolomics.jp/wiki/Category:FL
http://taxonomicon.taxonomy.nl).
Las propiedades cido-base muestran que los radicales flavonoides son neutros
en un medio cido (por debajo de pH 3) y con una carga negativa a pH 7. Las
repercusiones de la carga negativa son sumamente
importantes en la evaluacin del potencial antioxidante
de los flavonoides Primero, el radical
cargado negativamente no es probable que pase a
travs de la membrana celular con carga negativa.
Segundo, la reaccin de los radicales flavonoides
con la vitamina E, que es termodinmicamente factible
para algunos radicales flavonoides, tiene un obstculo
adicional a causa de la repulsin electrosttica
entre el anin del radical flavonoide y la membrana
fosfolipdica cargada negativamente, donde la vitamina
E se incrusta. Tercero, la oxidacin de un slo
electrn de los flavonoides por cualquier oxidante
tendr una barrera entrpica, porque por lo menos
dos protones se intercambian en la reaccin. Los
protones pueden intercambiarse entre los reactantes
o con el solvente en el estado de transicin, en este
caso, la interfase del enlace con hidrgeno debe tenerse
en. cuenta15
hacen particiones sucesivas con ter etlico, acetato de etilo y n-butanol. Los
flavonoides
apolares quedan en la fase etrea, los medianamente polares en la fase
acetato de etilo y los
ms polares en el n-butanol
http://www.hindawi.com/journals/tswj/2013/162750/
Flavonoidspossessmanybiochemicalproperties,butthebestdescribed
propertyofalmosteverygroupofflavonoidsistheircapacitytoactasantioxidants.
Theantioxidantactivityofflavonoidsdependsuponthearrangementoffunctional
groupsaboutthenuclearstructure.Theconfiguration,substitution,andtotalnumber
ofhydroxylgroupssubstantiallyinfluenceseveralmechanismsofantioxidant
activitysuchasradicalscavengingandmetalionchelationability
(http://www.hindawi.com/journals/tswj/2013/162750/)
radicalscavengersandinhibitorsoflipidperoxidationin vitro[74].Becauseof
oxidation on the B ring of flavonoids having catechol group a fairly stable
orthosemiquinoneradicalisformedwhichisstrongscavengers.Flavoneslacking
catecholsystemonoxidationleadtoformationofunstableradicalsexhibitweak
scavenging potential [75]. The literature shows that flavonoids having an
unsaturated 23 bond in conjugation with a 4oxo function are more potent
antioxidantsthantheflavonoidslackingoneorbothfeatures.Conjugationbetween
theAandBringsallowsaresonanceeffectofthearomaticnucleusthatprovides
stability to the flavonoid radical. Free radical scavenging by flavonoids is
potentiatedbythepresenceofboththeelementsbesidesotherstructuralfeatures
[76].
The flavonoid heterocycle contributes to antioxidant activity by permitting
conjugationbetweenthearomaticringsandthepresenceofafree3OH.Removal
of a 3OH annuls coplanarity and conjugation which compromises scavenging
ability[77].ItisproposedthatBringOHgroupsformhydrogenbondswiththe3
OH,aligningtheBringwiththeheterocycleandAring.Duetothisintramolecular
hydrogenbonding,theinfluenceofa3OHisenhancedbythepresenceofa3 ,4
catechol,elucidatingthepotentantioxidantactivityofflavan3olsandflavon3ols
that possess the latter feature. Generally Omethylation of hydroxyl groups of
flavonoidsdecreasestheirradicalscavengingcapacity[76].
Occurrence, position, structure, and total number of sugar moieties in flavonoid
(flavonoidsglycosides)playanimportantroleinantioxidantactivity.Aglyconesare
morepotentantioxidantsthantheircorrespondingglycosides.Therearereportsthat
theantioxidantpropertiesofflavonolglycosidesfromteadeclinedasthenumberof
glycosidic moieties increased [78]. Though glycosides are usually weaker
antioxidants than aglycones, bioavailability is sometimes enhanced by a glucose
moiety.Inthediet,flavonoidglycosidicmoietiesoccurmostfrequentlyatthe3or
7position[79].Increasingdegreeofpolymerizationenhancestheeffectivenessof
procyanidinsagainstavarietyofradicalspecies.Procyanidindimersandtrimersare
more effective than monomeric flavonoids against superoxide anion. Tetramers
exhibitgreateractivityagainstperoxynitriteandsuperoxidemediatedoxidationthan
trimers,whileheptamersandhexamersdemonstratesignificantlygreatersuperoxide
scavengingpropertiesthantrimersandtetramers
The precondition to their radical scavenging effect is the number and location
of phenolic groups.2 For example the ortho-dihydroxy (catechol) substitution
raise the radical scavenging activity.3 However, the synthesis of these complex
compounds is complicated given that the selective transfer of oxygen atoms to
non- or little activated carbons is still a challenging reaction in chemical
synthesis.4 (reaccion flavonoide-aromatico)
only does so by being an effective diluent. It does not break down the agglomerates by any
significant amount.
The intention is to then augment the better of these additive compounds with kerosene, thus
initiating viscosity reduction for less volume of diluent.
augment
increases viscosity. The viscosity reduction however may not just be related to the
break down of
the asphaltene agglomerates. A more simple answer may be related to Eyrings theory
of liquid
viscosity (5).
polarities
between 1 and 3 DU. Therefore, partial solubility must be the cause for the lower measurements.
However, solubility experiments should be conducted to prove this hypothesis