AML M0
AML M1
AML M2
M3
M4
M5
M6
M7
FLT3
KIT
WIlms Tumor
NPM1
CEBPA
ALL
Other Name
Acute Promyelocytic
(APML)
Acute Myelomonocytic
Acute Monocytic
Acute Erythroleukemia
Acute Megakaryocytic
Catagory
Predominant Cell
AML
AML
AML
AML
Myeloblast
Myeloblast
Myeloblast
AML
AML
AML
Myeloblast, Monocytes
Monocytes
Dysplastic Erythroid,
myeloblasts
AML
AML
mut
AML
mut
AML
mut
AML
mut
AML
mut
ALL
w
w
w
w
w
gene
gene
gene
gene
gene
Lymphocytes, smudge
cells
CML
CML
ATLL
CLL
13
4
11
5
B cells
CLL
PLL
HCL
TPLL
t(8:21)
t(15:17)
Chrom
Chrom
Chrom
Chrom
CLL
Genetic
Change
Prolymphocytes
CD4
CLL
Granular Lymphocytes
T cell
MZL/MALToma
NHL
philadelphia
chrom
t(9:22)
NHL
NHL
Follicular Lymphoma
NHL
NHL
LBCL- Centroblastic
NHL
LBCL- Immunoblastic
NHL
NHL
Anaplastic LBCL
NHL
Thymic LBCL
NHL
NHL
NHL
NHL
Burkitt Lymphoma
NHL
B cells
NHL
Plasma cells,
lymphocytes, eosinophils
Mucosis Fungoides
NHL
NHL
HL
Mixed Cellular HL
HL
lots of lymphocytes w
some tissue macrophages
RSC
Lymphocyte Depleted HL
HL
RSC
Monocytoid B
deletion
7q21
t(14:18) bcl2
and cmyc
t(11:14)
cyclinD
cMyc
t(8:14)
trisomy 8
Nodular Sclerosing HL
HL
Benign
Toxoplasmosis Lymphadenitis
Benign
Benign
Granulomatous Lymphadenitis
Benign
Kikuchi Disease
Benign
Sacoidosis
Benign
Cat Scratch
Benign
Lymphogranuloma venerum
Benign
Benign
Infectious Mono
Benign
Benign
Benign
Viral Lymphadenitis
Benign
Rheumatoid Arthritis
Benign
SLE
Castlemans
Benign
Benign
Rosai-Dorfman
Benign
Histiocytes
Kimuras
Benign
Histiocytes
Whipples
Benign
Foamy Macrophages
Benign
Bland Macros
Dermatopathic Lymphadenitis
Benign
FAS(CD95)
caspase 10
Jak2
Autoimmune Lymphoproliferative
Syndrome
ALPS
Benign
Mycocutaneous Syndrome
Kawasaki Disease
Benign
P Vera
MPD
Russel bodies
Areas
found
Marrow
Marrow
Marrow
Marrow
Marrow
Marrow
Marrow
Markers
Key morphology
Few Granules
Few Granules
FISH test
Auer Rods,
Hypergranular
Non specific esterase Vacuoles in cytoplasm
Blue cytoplasm
Marrow
Marrow
Marrow
Marrow
Marrow
Marrow
TdT+, CD19+, CD10
Prognosis
BM, spleen
CD20, no CD5
TRAP stain
CD3
ATRA
H pylori
general vague
symptoms
Bad
Bad
Bad
Bad
Good
Good
No auer rods, almost no Good: 2-10 yo,
cytoplasm, dense
diploidy. Bad: very
chromatin
young, philly chrom
imatinab
splenomegaly, purpura,
anemia, priapism,
fatigue
Clinical Presentation
Good
Therapy
Large, granules
criboform nuclei
skin lesions,
lymphadenopathy,
hypercalcemia
Red patches all over
marrow,
blood
villous projections
neutrophil infiltation in
marginal zones
bulging follicles
aggressive
CVP,
Rituximab
small cells
indented cells
immunodeficiecy,
autoimmune
comorbidities
aggressive
HIV pts
HIV pts HHV8
aggressive
CD10 BCL6
criboform nuclei
sinusoidal infiltration
Cd15 neg, CD30 neg, popcorn cells, pufy
CD20+
nuclei on RSC
heterogenous cellular
infiltrates
very few lymphocytes
R-CHOP
aggressive
B symptoms present
when disease is
advanced
skin lesions
Rituximab
ABVD,
Stanford 5
ABVD,
Stanford 5
lower
cervical,
supraclavicul
ar,
mediastinal
LN
Lacunar RSC,
collagenic fibrous
bands
unilateral
posterior LN
follicular hyperplasia,
histiocytes, pink pufy
macrophages, maybe a
cyst
Good
ABVD,
Stanford 5
Variation in sizes of
follicles, tingible body
macrophages
surrounds blood
vessels, histiocytes,
capsule, spirochetes
macrophages w C
shaped nuclei,
monocytes w round
nuclei
bartonella
chlamydia
Fever
ateroid bodies,
schaumen bodies
(laminar concretions)
calcium oxalate
crystals
follicular hyperplasia,
granuloma w
pallisading
macrophages
follicular hyperplasia,
granuloma w
pallisading
macrophages
from hyperplasia to
involution to depletion
resembles lymphoma
monocytes and
lymphocytes with
macrophages (looks
like burkitts)
S100
interfollicular
plasmacytosis
Necrotic Debris
Onion skin and
lollipops, sheets of
plasma
cells
Sinus histiocytes
fevers, neutrophilia,
high ESR
fevers, neutrophilia,
high ESR
malabsorbtion in GI,
weight loss, tetani,
seizures, bruising
Sinus histiocytes
Trooheryma whippelii Foamy macros
CD5 B cells
absence of follicles
Phlebotomy
asymptomatic to
splenomegaly,
hyperviscocity, buddchairi syndrome,
pruritis
Age
Sex
Prevalence
Adult
Adult
Adult
Adult
Other
Adult
Adult
Adult
Adult
Tyr Kinase receptor
Tyr Kinase receptor
Children
adult
Men
70 Men
Most
common
leukemia in
Adults
Rare
men
older
females
50-60
white peeps
most
common
Rare
30s women
Most
common
Need Intrathecal
Chemo, therapy results
in sterility
adult
young
black males
40s
over 50
older
Men
least
common HL
young
women
common
women
middle age
men
increases risk of
lymphoma
in young childrenheart attack
adult
males
rare
Drug
Subclass
Class
Mechlorethamin N Mustards
e
Alkylating
Alkylates Guanine,
cross links strands
Cyclophosphami N Mustards
de
Alkylating
Metabolites damage
DNA
Ifosfamide
N Mustards
Alkylating
Chlorambucil
N Mustards
Alkylating
Busulfan
Carmustine
Alkyl
Alkylating
Sulfonates
Nitrosoureas Alkylating
Cisplatin
Metal Salt
Oxaliplatin
Doxorubicin
Bleomycin
Methotrexate
MOA
Stage
Effective
Not CCS
MOR
Tx for
Decrease
Permeability
HL
Not CCS
Decrease
Permeability,
increase repair
BL, Breast
Metabolites damage
DNA
Not CCS
Decrease
Permeability,
increase repair
BL, Breast
Metabolites damage
DNA
Not CCS
Decrease
Permeability,
increase repair
Leukemia/Ly
mphoma
Not CCS
crosslinks and
alkylates especially
in replicating cells
Not CCS
CML
Unknown
Alkylating
HL, NHL,
Brain,
leukemia
Solid Tumors
HL,
testicular,
Lung
Lots and Lots
drug efflux
nonprolif cells
immune, enzyme
changes
Solid Tumors
Lots and Lots
Mercaptopurine Purine
Analog
Cannot transform
drug to active
form
Cytarabine
Pyrimadine
Analog
Leukemia
5-Flurouracil
Pyrimadine
Analog
Vincristine
Vinca
Alkaloid
drug efflux
Rapidly
dividing
tumors
Vinblastine
Vinca
Alkaloid
drug efflux
Rapidly
dividing
tumors
Etoposide
S, G2
P-glycoprotein
G2, M
P-glycoprotein
Not CCS
Not CCS
ALL
Breast
LH
Not CCS
Prostate
Paclitaxel
Asparaginase
Tamoxifen
Leuprolide
Hormones
Breast,
Ovarian
ADR
Notes
Myelosuppression
, Pain at injection,
N/V
alopecia, N/V,
Hemorrhagic
Cystitis
Taken Orally,
P450 metab
Neurotox
Taken Orally,
P450 metab
Hematologic Tox
Pulmonary
Fibrosis
Hemapoeietic
Depression,
Renal Tox
Imatinib
used more
Nephrotox (renal
tube dmg)
Nephrotox (renal
tube dmg)
Cardiotox
PULMONARY
FIBROSIS
Lots of drug
interations
Weak acid,
should
alkalize urine
Bone marrow
suppression
NEUROTOX
Bone marrow
suppression
2ndary leukemia
NEUTROPENIA
Hyperglycemia
menstrual
abnormalities
Drug
MOA
Target
Thrombin
Heparin
Potentiates antithrombin III
Antithrombin III
Bivaliruden Reversible Thrombin inhibitor
Lepirudin
Inhibts thrombin (irreversible
Argatroban Blocks thrombin related rxn
(Fibrin, V, VIII, XIII)
Warfarin
Vit K antagonist
thrombin
Free and Clotted
thrombin
Vit K
plasminogen
plasminogen,
plasmin
Admin
Used for
Topical Powder Burns
IV
DVT, PE
IV
percutaneous
coronary angioplasty
IV
Pts with HIT
IV
Pts with HIT
Side effects
Random hemorrhage
Random hemorrhage
Random hemorrhage
Random hemorrhage
PO
Afib
Random hemorrhage
PO
PO
PO
Random hemorrhage
PO
PO
Acute Cerebral
ischemia
Angioplasty
PO
CV
PO
prothetic heart
valves
TTP
PO
plasminogen
CVA
plasminogen,
fibrin
CVA
IV, PO
myopathy necrosis
Monitoring
Other
PTT
Very short T1/2
PTT
PT
Very narrow
therapeutic range
Systemic activator
systemic activator
Clot specific