Immune
Response to
InfectiousDiseases
Zhong yiwei
20110430
ImmunedefenseVSpathogeninfection
Infectious Diseases
InfectiousDiseases
ViralInfections
Bacterial Infections
BacterialInfections
ProtozoanDiseases
DiseasesCausedbyParasiticWorms(Helminths)
sitesofinfection
Mechanismsofviral entryintohost
cells.
cells
acuteinfectionsandpersistent
infection
Hostresponseagainstacuteinfection
Theinnateimmuneresponsetoviral
infection
AdaptiveImmuneResponsetoViral
Infections
VirusesCanEvadeHostDefense
Mechanisms
i fl
influenzavirusinfection
i i f i
1918
19182009
2009
Sitesofinfluenzaentryinthe
respiratorytract.
Theadaptiveimmuneresponseduring
infectionwithinfluenzavirus.
influenzaVirusesEvadedHostDefense
Mechanisms
Theviruscanchangeitssurfaceantigensso
completelythattheimmuneresponse
Twodifferentmechanismsgenerateantigenic
Two different mechanisms generate antigenic
variationinHAandNA:antigenicdriftand
antigenicshift.
i i hif
Antigenicshift
Types of vaccine
Typesofvaccine
Inactivatedvirus
Liveattenuatedvirus
Live attenuated virus
Recombinantsubunit,DNAandvectored
vaccines.
i
Universalinfluenzavirusvaccines.
Newresearchforinfluenza
Eachgroupseemstosharearegionofsequence
conservationinthestemthatcanserveasatargetof
broadlyneutralizingantibodiesdirectedtothis
region.
i
HBV
ThethreemainpathwaysofHBvreplicationin
HBeAg positive patients
HBeAgpositivepatients
immuneresponsetoHBVinfection
p
1
1
HBV
HBV
2
2
TLRIFN
APC
APC
Ttreg
Differenthepaticantigenpresentingcellsuse
B7H1topromotelocalTcelltolerance.
HIV Infection
HIVInfection
dendriticcell
(DC)
(DC)mediated
di t d
HIVtransmission
CD4andCD8cellnumberduringthe
courseofHIVinfection
MechanismsofCD4+TcelldeathinHIVinfection
viralload,andCD4cell countwillhelpyourdoctordeterminethe
righttimetostarttherapy
HIVmedicationsorARVtherapy,including:
NNRTIs(ornonNucs):Nonnucleosidereversetranscriptaseinhibitors
NRTIs(orNucs):Nucleosidereversetranscriptaseinhibitors
PIs:Proteaseinhibitors
hb
Entryinhibitors
Integraseinhibitors
HIVVaccine
ImmuneResponsetoBacterial
Infections
Extracellular vs intracellularbacteria
Extracellularvs
intracellular bacteria
Extracellularbacteria:
Phagocyte avoidance!!
Phagocyteavoidance!!
Intracellularbacteria:
Cellmediated
Cell
mediatedisthemajorimmuneresponse
is the major immune response
againstintracellularbacteria.
ImmuneResponsetoBacterialInfections
Antibodymediated
mechanisms
forcombating
infection by
infectionby
extracellularbacteria.
Invademechanismsbyextracellular
bacteria
bacteria
Tuberculosis
Tuberculosis
PhasesofinfectionMycobacterium
tuberculosis.
tuberculosis
ThenaturalhistoryofMycobacterium
tuberculosisinfection.
Macrophagesarekeyeffectorcellsinmycobacterialkilling,butcanalsoprovidea
nicheforbacterialmultiplication.
EventsthatmightleadtofailureofBCGindeveloping
countries
ImmuneResponsetoDiseases
Immune
Response to Diseases
CausedbyParasiticWorms
y
Bodycovering
Sex
Examplediseasesin
humans
Cestodes (tapeworms)
Trematodes (flukes)
Nematodes
Nematodes
(roundworms)
Tegument
Tegument
Cuticle
Hermaphroditic
Hermaphroditic,except
Hermaphroditic,
except
schistosomes whichare Dioecious
dioecious
Tapeworminfection
p
Schistosomiasis,
swimmer's itch
swimmer'sitch
Ascariasis,,
dracunculiasis,
elephantiasis,
enterobiasis (pinworm),
filariasis hookworm
filariasis,hookworm,
onchocerciasis,
trichinosis,trichuriasis
( p
(whipworm)
)
Schistosomiasis
Schistosomiasisiscausedbydigeneticbloodtrematodes.
ThethreemainspeciesinfectinghumansareSchistosoma
haematobium S japonicum and S mansoni
haematobium,S.japonicum,andS.mansoni.
Life Cycle
LifeCycle
Afterinfectionwith
Schistosoma mansoni,
theinitialimmune
response
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