Artocarpus merupakan salah satu genus terpenting dalam famili moraceae.

Artocarpus memiliki banyak

kegunaan antara lain pengobatan sirosis, hipertensi, diabetes, peradangan, demam malaria, antiplatelet,
antibakteri, antifungi, dan sitotoksik. Karya tulis ini dibuat untuk mengkaji tinjauan pustaka, kandungan
senyawa dan aktivitas farmakologi dari beberapa spesies Artocarpus diantaranya Artocarpus altilis (Sukun),
Artocarpus heterophyllus (Nangka), dan Artocarpus camansi (Kluwih). Genus Artocarpus memiliki kandungan
senyawa yang beragam seperti terpenoid, steroid, fenolik, flavonoid, stilbenoid, arilbenzofuran, dan jacalin.
Berdasarkan penelitian Artocarpus altilis memiliki aktivitas antioksidan yang lebih kuat dibandingkan dengan
Artocarpus heterophyllus dengan nilai IC50 63,79 g/mL. Sedangkan pada pengujian antidiabetes dari ketiga
spesies tersebut diketahui Artocarpus altilis dan Artocarpus heterophyllus memiliki aktivitas sebagai inhibitor
-glukosidase, sedangkan Artocarpus camansi memiliki aktivitas antidiabetes yang mampu meregenerasi selsel -pankreas yang rusak serta diduga dapat memperbaiki reseptor insulin. Dalam beberapa penelitian yang
telah dilakukan Artocarpus altilis dan Artocarpus heterophyllus memiliki aktivitas sebagai inhibitor biosintesis
melanin. Artocarpus heterophyllus memiliki daya inhibisi tirosinase yang lebih kuat dibandingkan Artocarpus
atlilis terlihat dari meningkatnya persentase inhibisi yang menunjukkan bahwa pembentukan produk
dopakuinon mengalami penurunan. Berdasarkan review dari beberapa jurnal penelitian, diketahui bahwa
Artocarpus altilis dan Artocarpus heterophyllus memiliki aktivitas sebagai antioksidan, antidiabetes dan
inhibitor biosintesis melanin. Sedangkan Artocarpus camansi memiliki aktivitas sebagai antidiabetes.
Ke 1

Artocarpus is one of the most important genus in the family Moraceae. Artocarpus has many
uses include the treatment of cirrhosis, hypertension, diabetes, inflammation, fever, malaria,
antiplatelet agents, antibacterial, antifungal, and cytotoxic. This work has been made to study
the literature review, compound and pharmacological activity of some species such
Artocarpus Artocarpus altilis (breadfruit), Artocarpus heterophyllus (Nangka) and Artocarpus
camansi (artocarpus camansi). Genus Artocarpus contains diverse compounds such as
terpenoids, steroids, phenolics, flavonoids, stilbenoid, arilbenzofuran, and jacalin. Based on
research Artocarpus altilis have more powerful antioxidant activity compared with Artocarpus
heterophyllus with IC50 value of 63.79 mg / mL. While the antidiabetic testing of all three
species are known Artocarpus Artocarpus heterophyllus altilis and has activity as an inhibitor
of -glucosidase, while Artocarpus camansi have antidiabetic activity that is able to
regenerate -cells of the pancreas are damaged and could be expected to improve insulin
receptor. In some studies that have been conducted and Artocarpus heterophyllus Artocarpus
altilis have activity as an inhibitor of the biosynthesis of melanin. Artocarpus heterophyllus
has tyrosinase inhibition power is stronger than Artocarpus atlilis evident from the increasing
percentage inhibition indicates that the product formation dopakuinon decreased. Based on a
review of several research journals, note that altilis and Artocarpus Artocarpus heterophyllus
have antioxidant activity, antidiabetic and melanin biosynthesis inhibitor. While Artocarpus
camansi have activity as an antidiabetic.
Ke 2
Artocarpus is one of the most important genus in the family moraceae. Artocarpus has many
uses, among others, the treatment of cirrhosis, hypertension, diabetes, inflammation, malarial
fever, antiplatelet, antibacterial, antifungi, and cytotoxic. This paper was made for examines
the literature review, and pharmacological activity of the compound content of several
species of Artocarpus altilis including Artocarpus (Breadfruit), Artocarpus heterophyllus
(Jackfruit) and Artocarpus camansi, (Kluwih). The genus Artocarpus contain compounds
diverse such as Terpenoids, steroids, flavonoids, phenolic stilbenoid,, arilbenzofuran, and
jacalin. Based on previous research, Artocarpus altilis has stronger antioxidant activity
compared to Artocarpus heterophyllus 63.79 IC50 value of g/mL. While in testing anti
diabetic these third species, Artocarpus altilis and Artocarpus heterophyllus has inhibitors of
-glucosidase activity, while Artocarpus camansi has anti diabetic activity that is able to
regenerate cells of pancreatic -cells are broken and supposedly can improve insulin

receptors. In some of the research that has been done Artocarpus altilis and Artocarpus
heterophyllus has inhibitors of the biosynthesis of melanin activity. Artocarpus heterophyllus
have stronger tyrosinase inhibition than Artocarpus atlilis that have been seen from the
increasing percentage of inhibition which suggests that the form of the dopakuinon products
has decreased. Based on a review of some research journals, Artocarpus altilis and Artocarpus
heterophyllus has known as antioxidant activity, melanin biosynthesis inhibitors and anti
diabetic. While Artocarpus camansi has anti diabetic activity.
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