Review
Gynecology, Bologna Toniolo Clinic, Bologna, Italy, and 3Department of Public Health, University of Parma, Parma, Italy
Introduction
Hypertension during pregnancy is currently one of the main
causes of maternal mortality and morbidity and is associated with
prematurity and increased perinatal mortality [1].
Blood pressure measurements taken 6h apart equal to or
greater than 140/90mmHg, in formerly normotensive women,
after the 20th week of pregnancy, without proteinuria, defines
pregnancy-induced hypertension (PIH) [2]. Preeclampsia is a
clinical syndrome of unknown etiology characterized by the
occurrence of hypertension and proteinuria after 20 weeks of
gestation, in formerly normotensive women.
During pregnancy and nursing, calcium requirements are
increased in order to maintain calcium balance and maternal
bone density, and to satisfy fetal growth requirements.
Methods
We examined international literature regarding calcium
supplementation for the prevention of preeclampsia. The search
string used by MEDLINE/Pubmed was calcium supplementation
prevention preeclampsia. The electronic research yielded 113
results, 56 reviews. We considered eligible for our meta-analysis
all RCT (random allocation of calcium versus placebo) available
in English-language Journals up to 2/29/2012 regarding calcium
supplementation during pregnancy for preventing preeclampsia,
regardless of the age, parity, clinical and family history of all
Correspondence: Tito Silvio Patrelli, MD, Dipartimento di Scienze Ostetriche, Ginecologiche e di Neonatologia, U.O.C. di Ginecologia e Ostetricia, Viale
Gramsci, 1443100 Parma Italy. Tel.: +39 339 2817381. E-mail: titosilvio.patrelli@gmail.com
2570
Results
In total, 16 studies were examined.
Discussion
The Journal of Maternal-Fetal and Neonatal Medicine
Acknowledgments
The Authors thanks to Mrs. Carolyn David for her precious help
in proofreading the English.
Declaration of Interest: The authors report no conflicts of interest.
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