Maam Gutierrez
Hemostasis
- maintaining the blood in a clot free/fluid state inside a vascular
compartment
- process by which the body stops bleeding
Secondary HS. When fibrin gets deposited at the injury site together
with the platelets, it makes the platelet plug more stable.
The Clotting/Coagulation Factors
- most are inherited: autosomal recessive
- almost all of them are glycoproteins so expect them to be
manufactured in the Liver.
In liver disorder, it is not impossible for the patient to bleed.
Exceptions:
Fibrinogen
FACTOR II
Prothrombin
FACTOR III
Tissue Thromboplastin
FACTOR IV
Calcium
- mediators of inflammation
vWF
- not in itself a clotting factor, only a cofactor.
FACTOR V
Labile Factor/Proaccelerin
Stable Factor/Proconvertin/
Serum Prothrombin Conversion
Accelerator (SPCA)
FACTOR VII
Antihemophilic Factor A/
FACTOR VIII
FACTOR IX
- autosomal recessive
Plasma Thromboplastin/
Christmas Factor/
Antihemophilic Factor B
FACTOR X
FACTOR XI
Antihemophilic Factor C
Hageman Factor/Contact
FACTOR XII
Factor/Glass Factor
Laki-lorand Factor/
FACTOR XIII
Fibrin Stabilizing Factor
PREKALLIKREIN
Fletcher Factor
Fitzgerald Factor/Contact
KINNINOGEN
Kinins
activation Factor/Williams/Flaujeac
F.
- Paul Morawitz
TF = (thromboplastin + phospholipid)
Intrinsic Pathway
- called intrinsic because all that is needed in this pathway is
already present, not like the tissue factor which is released only after a
vascular injury. All factors are initially found inside the vascular
compartment.
- initiated by Collagen Exposure. Collagen has a negatively
charged surface that through contact activates Factor 12, becomes
Factor 12a. (Contact Phase)
Collagen + CF12 -- CF12a
CF12a combines with HMWK and leads to 2 different events.