Introduction:
The prostate is a fibro-muscular gland which
surrounds the prostatic urethra. It is traversed
by the urethra and ejaculatory ducts. The
prostate gland is lobulated but can only be
distinguished in the fetal gland. The zonal
anatomy of the glandular part is clinically
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RCMC Journal
Parameters:
The following parameters were studied for
each animal & comparative studies were made
among different group of animals.
i)
RCMC Journal
Table: I
Grouping of rats, doses of drugs, and vehicle, duration of treatment and sacrifice schedule of the experiment.
Groups
(n)
Feeding status
Route of
administration
Duration of
treatment
(days)
Day of sacrifice
(15th days)
A (Control)
12
Normal food +
water
Subcutaneous
14
15
B (Experimental
control) 12
Normal food +
water
Testosterone propionate
200g
Subcutaneous
14
15
C (Experimental)
12
Normal food +
water
Testosterone
propionate 200g +
Finasteride 4mg
Subcutaneous
14
15
D (Experimental)
12
Normal food +
water
Testosterone
propionate 200g +
Finasteride 8mg
Subcutaneous
14
15
Table: II
Comparison of initial and final body weight of the rats of different groups
Initial (Mean SD)
(Range)
196.67 3.892
190 - 200
p Value
206.67 6.853
200 - 220
> .05
196.67 6.155
190 - 205
202.50 5.00
195 - 205
> .05
197.08 6.557
185 - 205
203 5.721
195 - 210
> .05
195.94 5.894
180 - 200
202.08 6.557
195 - 205
> .05
Groups
A
Body wt in gm
250
200
150
100
50
0
Gr. A
Gr. B
Gr. C
Gr. D
Fig I - Initial and final body weight (gm) of rats of Fig II -Weight (mg) of the prostate of different
different groups
groups of rats
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RCMC Journal
Table III
Comparison of weight of the prostate between
diffierent groups
Weight of the prostate (mg)
Group
Mean SD
Range
476.75 9.196
465 - 491
637.92 18.520
600 - 665
378.75 8.001
370 - 390
73.50 6.289
165 - 182
Gr A vs B
p - Value
< .001
Gr A vs C
< .001
Gr A vs D
< .001
Gr B vs C
< .001
Gr B vs D
< .001
Gr C vs D
< .001
Discussion:
Finasteride is one of the new class of drug 5alpha reductase inhibitor that are potentially
useful in treating benign prostatic
hyperplasia.5 It slows the conversion of
testosterone to dihydrotestosterone. The
present study was an attempt to evaluate the
effect of finasteride at two different doses on
androgen induced prostatic hyperplasia in
experimental rats. The average body weight
gain in all groups of rats treated with
testosterone plus finasteride has no significant
effect on general metabolism of animals of
having normal hormonal status. So there was
no significant difference in body weight gain
in control and experimental groups. The result
of present findings was compatible with the
results of Fleshner and Trechtenberg7,
Begum.8
Weight of the prostate, testes and seminal
vesicle increased significantly in the
RCMC Journal
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Conclusion:
Comparative study of finasteride with other
5-reductase inhibitor is necessary. The study
of hormone profile and studies with larger
samples with different doses and duration
are recommended.
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References:
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