GENERIC NAME

METRONIDAZOLE

BRAND NAME

Apo-Metronidazole (CAN), Flagyl, Flagyl 375, Flagyl

ER, Flagyl IV, MetroGel, MetroGel-Vaginal, NidaGel
(CAN), Noritate, Protostat
Antibiotic, Antibacterial, Amebicide, Antiprotozoal
Metronidazole is converted to reduction products that
interact with DNA to cause destruction of helical DNA
structure and strand leading to a protein synthesis
inhibition and cell death in susceptible organisms. It is
effective against a wide range of organisms
07/19/13 (Pre-operative)
60mg IV via soluset q8h
Prophylaxis for patients undergoing surgery
History of hypersensitivity to metronidazole or other
nitroimidazole derivatives.
GI disturbances e.g. nausea, unpleasant metallic taste,
vomiting, diarrhoea or constipation.
Numbness or tingling in the extremities, epileptiform
seizures (high doses or prolonged treatment).

CLASSIFICATION
MODE OF ACTION

DATE ORDERED
DOSAGE
INDICATION
CONTRAINDICATIONS
ADVERSE EFFECTS

NURSING
RESPONSIBILITIES

Hypersensitivity reactions. Urethral discomfort

and darkening of urine. Raised liver enzyme
values,
cholestatic
hepatitis,
jaundice.
Thrombophlebitis (IV).

Potentially Fatal: Anaphylaxis.

BLACK BOX WARNING: Avoid use unless

necessary. Metronidazole may be carcinogenic.

Reduce dosage in hepatic disease.

Your urine may be a darker color than usual; this

is expected.

Report severe GI upset, dizziness, unusual

fatigue or weakness, fever, chills.