7/17/2014

Inhalers
J.Sanjeyan [2010/FM/26]
Lingagini.S [2010/FM/92]
33rd Batch
FacultyofMedicine
UniversityofJaffna

Delivery depends on..

Particle
Size & Shape
particle density
solid
solid or liquid phase
Type of inhalation
device
Technique
Airwayobstruction
Drug molecule

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Aim of Inhalers
Aim
To makeaerosolfromthedrug
solution orsolid particles
To
To deliver thelung
the lung efficiently.
efficiently

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Pharmacokinetics

Why inhalers
Targeted delivery of
medication tothelungs
Rapid onsetof action
Smaller doses
Less systemic and GIadverse
effects
Relatively comfortable
J. Sanjeyan & S.Lingagini,
Faculty of Medicine, University of Jaffna,
Sri Lanka

Classification
1.Metered-Dose Inhalers
2.Dry Powder Inhalers
3.Nebulizers

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

7/17/2014

Metered-Dose Inhalers
MDI/ DPI

Nebulizer

Small volumes
Ready for use

High volume(>1ml)
Preparation
required
Severe respiratory
insufficiency
(asthmaattack,
CO PD etc.)

Stable
obstructive
disease

Gas Phase

(Liquid Phase)

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

MDI Disadvantages
Handbreathe coordinations
Ineffective inpoor ventilated
patiens
Oropharyngeal deposition and
localside effects
Not include dose meter
J. Sanjeyan & S.Lingagini,
Faculty of Medicine, University of Jaffna,
Sri Lanka

MDI advantages
Rapid application
Easy handling
Multidose

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

MDIefficientuse

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

MDIefficientuse
Spacer

Spacer

(For those who areunable to afford)

Decrease off
oropharyngeal
deposition

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

7/17/2014

MDIefficientuse
Baby Mask

MDIefficientuse
Autohaler

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Dry Powder Inhalers

DPhaler
Diskhaler
Flowhaler
Turbuhaler
Handihaler
Etc
J. Sanjeyan & S.Lingagini,
Faculty of Medicine, University of Jaffna,
Sri Lanka

Checking doses

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Dry Powder Inhalers

DPhaler

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Dry Powder Inhalers

Diskhaler

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

7/17/2014

Dry Powder Inhalers

Turbuhaler

Dry Powder Inhalers

Flowhaler

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Small and
convenient to
carry.

Require a deep,
fast breath.

MDI with
spacer
Less convenient to
carry than a
metered dose
inhaler without a
spacer.
Doesn't require a
deep, fast breath.
J. Sanjeyan & S.Lingagini,
Faculty of Medicine, University of Jaffna,
Sri Lanka

Handihaler

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

MDI, Spacer & DPI

MDI

Dry Powder Inhalers

MDI, Spacer & DPI

Dry powder
inhaler

MDI

MDI with
spacer

Small and
convenient to
carry.

Accidently
breathing out a
little isn't a
problem.

Accidently
breathing out a
little isn't a
problem.

Requires a deep,
fast breath.

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Dry powder
inhaler

Accidently
breathing out a
little can blow
away the
medication.
Can result in
Less medication
Can result in
medication on the settles on the back medication on the
back of throat and
back of throat and of throat
and
J. Sanjeyan & S.Lingagini,
University of Jaffna,
tFoacnultgy ouf Meed.icine,
tongue.
tongue.
Sri Lanka

MDI, Spacer & DPI

MDI with
spacer

Dry powder
inhaler

Requires shaking

Requires shaking
and correct use of
the spacer.
spacer

Humidity doesn't
affect medication.

Humidity doesn't
affect medication.

Single-dose
models require
loading capsules
High humidity can
cause medication
to clump.

Require
coordinating
No dose meter

Makes easier to
coordinate
.Line
gagtine
i, r
NoJ.dSanojeysane& Sm

MDI

Faculty of Medicine, University of Jaffna,

Sri Lanka

Doesn't require
high coordinating
Dosemeter

7/17/2014

NEBULIZERS
Nonpressurised liquid formulation

NEBULIZERS

JetNebulizer

Nonpressurised liquid formulation

Foot pumped model for areas
where is no electricity.

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

Ultrasonic Nebulizer

Thank you
J. Sanjeyan & S.Lingagini,
Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka

J. Sanjeyan & S.Lingagini,

Faculty of Medicine, University of Jaffna,
Sri Lanka