Q.

51 Fermi-resonance occurs when

(a) Energy of overtone more than fundamental mode
(b) Energy of fundamental mode than overtone
(c) Energy of overtone coincides with the fundamental mode. (d) None of the above.
Q.52 The unpaired electron of same spin is called
(a) Singlet excited state (b) Triplet state
(c) Both a and b
(d) Singlet ground state
Q.53 Principle involved in non aqueous titration of weakly basic drug
(a) Proton donation from acetic acid to drug
(b) Proton donation from onium ion to acetic acid
(c) Proton donation from perchloric acid to acetic acid (d) All of the above (e) None of the above
Q.54 The following compound exhibits ESR spectra.
(a) Diamagnetic
(b) Ferromagnetic (c) Paramagnetic
(d) None of the above
Q.55 Match the following
GC detector
Sensitivity
(a) FID
(i) 10-6
(b) ECD
(ii) 10-11
(c) TCD
(iii) 10-4
(iv) 10-12
(v) 10-9
(A) a-i b-ii c-iii
(B) a-i b-iv c ii
(C) a-iib-iv c-I
(D) a-iii b-v c-iv
Q.56 Chromatographic technique used in radio immunoassay
(a) Adsorption chromatography
(b) Affinity chromatography
(c) Gel-permeation chromatography
(d) All the above
Q.57 Edge effect is due to
(a) Unsaturation of the development chamber (b) Excess flow of solvent.
(c) Both a and b
(d) None of the above.
Q.58 Which of the following chromatographic system require the consideration of Compressibility factor
(a) liquid chromatography
(b) solid chromatography (c) both a & b
(d) none
Q.59 Which of the following method used for the calibration of
(a) Analytical or working curve (b) The method of standard addition (c) Internal standard method (d) all
Q.60 Which of the following derivative agent classified in the fluorsent derivatizing agent
(a) 4- Bromo methyl -7- methoxy coumerin
(b) 7- chloro 4- nitro benzyl-3oxo-1-3 diazole
(c) 1-dimethyl amino naphthalene-5-sulfuryl
(d) all
Q.61 Principle involved in detectors used in HPTLC
(a) Optical density
(b) Refractive index
(c) Absorption of light
(d)None of the above
Q.62 Mass chromatography lafferty rearranged ions are observed in the following.
(a) Aldehydes and ketones.
(b) Carboxylic acids and unsaturated compounds.
(c) Amines and amides.
(d) All the above
Note : - For the following questions mark the answer as a if both A and R are true and R is the explanation
for A . Mark the answer as b if both A and R true and R is not the explanation for A . Mark the answer as
c if A is true and R is false. Mark the answer as d if A is false and R is true. Mark the answer as e
if both A and R are false.
Q.63 Assertion : HPL columns are generally run at ambient temperatures , although increased efficiency can be
achieved at higher temperatures C
Reason :- At low temperature eluent Viscosities decrease and corresponding diffusion rates of solute in the
mobile phase and stationary phase increase
Q.64 Assertion : Free radicals and odd electron molecule absorb in visible region
Reason : Loosely bound electron can undergo transition even by absorbing radiation of lower frequency or
lower energy.
Q.65 Assertion :-Ignoring the bending vibrations the O-H stretching frequency in acetic acid is at higher
frequency than the C-H stretching frequency.
Reason :- O-H bond strength is higher than C-H bond.

Q.66 Assertion :- Conductance is an additive property of a solution

Reason:- Conductance depends on all the ions present in the solution, as each ion in solution acts as an
independent current carrier
Q.67 Assertion:Before measuring a polarogram, Nitrogen gas is bubbled through the solution in a polarographic
cell.
Reason :Oxygen is polarographically active.
Q.68 Assertion The CH3 protons in CH3 C Cl experience less deshielding in comparison to CH 3 protons in
CH3 Cl.
Reason: As the distance of the protons from the electronegative atoms Increases, the deshielding effect due to
it decreases.
CH3 Cl
CH3 C Cl
= 3.0
= 1.5
Q.69 Assertion : The compounds contain a hydrogen atom at the position gamma to the carboxyl group show a
relatively intense peak with an even m/e value
Reason : Due to Mc lafferty rearrangement fragmentation accompanied by loss of a neutral molecule.
Q.70 The intensities of fragment ions in the mass spectrum reflect
(a) On the stability of the ion
(b) On the energy relationship of the bond ruptured and formed during the reaction leading to the ion
(c) both are correct
(d) none
Q.71 Match the following colours with their respective indicators in acidic medium
1.Colourless

(a) KMno4

2. Pink

(b) Quinaldine red

3. Yellow green

(c) -naphthol benzene

4. Dark-green

(d) Oracet blue B

(e) Crystal violet

(a)1, B 2, D 3, E 4, B

(b) 1, B 2, E 3, D 4, B (c) 1, D 2, B 3, E 4, B (d) 1, B 2, D 3, B 4, E

Q.72 Match the following drugs with respective methods or reagents used for assaying
1. Metronidazole

(a) Non aqueous titration

2, Chlroambucil

(b) Sodium thiosulphate

3. Potassium permanganate

(c) Oxalic acid

4. Chlorinated lime

(d) Precipitation

(a) 1,A 2, D 3, C 4, B
Q.73 Assertion (A):

(b)1, A 2, D 3, B 4, C

(c) 1, D 2, A 3, C 4, B

(d) 1,B 2, D 3, C 4, A

Tetracyelines and chloramphenicol are the broad spectrum antibiotics.

Reason (R) : These drugs inhibit nucleic acid metabolism

(a) (A) is wrong (b)(R) is wrong (c) (A) & (R) are wrong (d) (R) is not answer for (A)
Q.74 Assertion (A): Imidazole antifungal agents inhibiting the synthesis of proteins are miconazole,
ketoconazole, clotrimazole.
Reason (R): The mechanism of action of those imidazoles are not clear. But they may alter the cell
permeability.

(a) (A) and (R) correct (b) (A) wrong (c) (R) wrog (d) (A) wrong & (R) correct
Q.75 clinically available anticancer agents have one of the underlying mechanism of
action. They act by
(a) improving body defence mechanism (b) inhibition of cell wall synthesis
(c) receptor blockade
(d) cell growth inhibition
Q.76 Benzorthine pencillin is
(a) Ammonium salt of pencillin G
(b) Benzyl salt of pencillin G
(c) Dibenzyl ethylene diamine salt of pencillin G (d) Naph though enter of pencillin G
Q.77 Although classified as antibiotics, dactinomycin and plicamycin are used in cancer chemotherapy
because they have on.
(a) Immuno suppressant effect (b) antiviral effect (c) ability to sterilize the blood (d) cytotoxic effect
Q.78 Match the following drugs with respective of mechanisms.
1. Gentamycin

a) Direct cell membrane action.

2. Ciprofloxacin

b) Inhibition of synthesis of cell wall

3. Cephalosporins

c) Drug binding to cell wall sterols

4. Nystatin

d) Inhibition of DNA sypercoiling and DNA synthesis

e) Inhibition of protein synthesis.

(a)1-e 2-d 3-b 4-c (b) 1-a 2-d 3-b 4-c (c) 1-e 2-a 3-b 4-c (d) 1-e 2-d 3-b 4-a
Q.79 Treatment of systemic fungal infection includes.
(a) Meconazole
(b) cyclonerine
(c) Ketaconazole
Q.80 A sulfonylarea having active metabolites is
(a) Chlorpropamide
(b) Tolbutomide
(c) Acetohexomide

(d) Amphotericin-b.
(d) Sulfacetamide