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2009 UpToDate

Vaughan Williams classification of antiarrhythmic drugs

Class IA - slows conduction velocity (less than class IC)
and prolongs action potential duration (APD)
Disopyramide
Procainamide
Quinidine

Class IB - has no effect on conduction velocity and may

shorten APD
Lidocaine
Mexiletine
Phenytoin
Tocainide

Class IC - slows conduction and may prolong APD (mild)

Flecainide
Propafenone
Moricizine

Class II - blocks beta adrenergic receptors

Beta blockers

Class III - prolongs APD and has no effect on conduction

Amiodarone
Dofetilide

Ibutilide
Sotalol*
N-acetyl procainamide (NAPA)
Azimilide

Class IV - calcium channel blockers

Nondihydropyridine calcium channel blockers (verapamil and
dilitiazem)

APD: action potential duration.

* I-sotalol has beta blocking and class III activities; d-sotalol is a
pure class III agent.
Azimilide blocks IKS and IKr others are predominantly IKr blockers.

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