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ChEn 3701: Introduction to Biomolecular Engineering

Fall 2016

Objective
To apply engineering principles to biological molecules and systems to improve our fundamental
understanding and our ability to leverage them for benefit.
Instructors
Professor Ben Hackel
356 Amundson Hall
hackel@umn.edu
Teaching Assistants
Max Kruziki
kruzi007@umn.edu

Sadie Johnson
joh10470@umn.edu

Katie Geldart
gelda002@umn.edu

Thu Phan
phanx247@umn.edu

Pedram Motallebnejad
motal005@umn.edu

Schedule
Lecture
Recitation 2
Recitation 3
Recitation 4
Recitation 6
Recitation 7

9:05 9:55 am
8:00 8:50 am
9:05 9:55 am
10:10 11:00 am
12:20 1:10 pm
2:30 3:20 pm

M, W, F
Tu
Tu
Tu
Tu
Tu

Office Hours
Monday
Monday
Tuesday
Tuesday
Thursday
Friday

2:30 4:30 pm
4:30 6:30 pm
2:00 4:00 pm
4:00 6:00 pm
2:30 4:30 pm
2:30 4:30 pm

Prof. Hackel
Katie Geldart
Sadie Johnson
Thu Phan
Pedram Motallebnejad
Max Kruziki

Content
Week of
Sept. 5
Sept. 12
Sept. 19
Sept. 26
Oct. 3
Oct. 10
Oct. 17
Oct. 24
Oct. 31
Nov. 7
Nov. 14
Nov. 21
Nov. 28
Dec. 5
Dec. 12

B75 Amundson Hall


116 Amundson Hall
124 Amundson Hall
212 Mechanical Engr.
120 Amundson Hall
6 Vincent Hall

Topics
Engineering in biology; cellular biology
Biological molecules
Enzymes
Enzymes; Protein-Protein Interactions
Protein-Protein Interactions
Protein-Protein Interactions
Pharmacokinetics
Replication, Transcription, Translation; Genomics
Protein Engineering
Recombinant Biologics, Cellular Reactors
Cellular Reactors
Cellular Reactors, Genetic stability
(no class Friday, November 25)
Metabolic Network Analysis + Engineering
Advances in Biomolecular Engineering
Review + Project Lecture

Prof. Hackel
Prof. Hackel
Prof. Hackel
Prof. Hackel
Sadie Johnson
Katie Geldart

356 Amundson Hall


161 Amundson Hall
161 Amundson Hall
161 Amundson Hall
161 Amundson Hall
161 Amundson Hall

Exams

Exam 1 (Oct. 5)

Exam 2 (Nov. 14)

Exam 3 (Dec. 12)


Final Exam (Dec. 20, 1:30 pm)

Instructional Materials
No textbook is required for this course since there is not a single text that adequately addresses all of the
topics in the course. Rather than requesting the purchase of several books, materials will be available in
multiple forms. Some materials will be posted to the Moodle website. Quality notes should be taken at
lecture and recitation. Reference books are available on reserve at Walter Library:
1. Biochemical Engineering Fundamentals, Bailey and Ollis
2. Bioprocess Engineering, Shuler and Kargi
3. Lehninger Principles of Biochemistry, Nelson and Cox
4. Molecular Cell Biology, Lodish
Homework
Homework will be assigned every week on Wednesday, will be due the following Wednesday at the
beginning of lecture, and will be returned in recitation the Tuesday thereafter. No late work will be
accepted. Collaboration on homework is acceptable, but each student is responsible to generate his/her
own, original solution. Homework must be presented neatly; credit will only be given if the method of
solution and final answer(s) are clearly evident.
Project
Literature research and quantitative analysis of one element (biology, production, processing, therapeutic
use, etc.) of a biological product will be performed in groups of three students and detailed in a report and
presentation. Details will be provided in recitation and on the class website.
Exams
Three midterm exams will be held during normal lecture time. The final exam will be Tuesday, December
20, 1:30 3:30 pm, B75 Amundson Hall.
Grading
Homework
Project
Midterm exams (15% each)
Final exam

18%
12%
45%
25%

Requests for regrades, including the homework/exam and a separate sheet describing what is disputed,
should be submitted to Prof. Hackel within three days after return of the homework/exam.
Student Academic Integrity and Scholastic Dishonesty
Academic integrity is essential to a positive teaching and learning environment. All students enrolled in
University courses are expected to complete coursework responsibilities with fairness and honesty. Failure
to do so by seeking unfair advantage over others or misrepresenting someone elses work as your own,
can result in disciplinary action. The University Student Conduct Code defines scholastic dishonesty as:
Scholastic Dishonesty: Scholastic dishonesty means plagiarizing; cheating on assignments or
examinations; engaging in unauthorized collaboration on academic work; taking, acquiring, or using test
materials without faculty permission; submitting false or incomplete records of academic achievement;
acting alone or in cooperation with another to falsify records or to obtain dishonestly grades, honors,
awards, or professional endorsement; altering forging, or misusing a University academic record; or
fabricating or falsifying data, research procedures, or data analysis.
Within this course, a student responsible for scholastic dishonesty can be assigned a penalty up to and
including an "F" or "N" for the course. If you have any questions regarding the expectations for a specific
assignment or exam, ask.

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