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Zabidah binti Ismail
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ARA Rahman
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ORIGINAL ARTICLE
Bioequivalence of propranolol
43
44
Ismail et al.
45
Bioequivalence of propranolol
120
100
Cp (ng/ml)
80
60
Inderal
Raza
40
20
0
0
10
15
20
25
Time (hr)
Figure 1. Mean plasma concentration of RAZA and Astra Zeneca 2 x 40 mg tablets of
propranolol.
Ismail et al.
46
AFA
AHH
KAJ
KNI
MIA
MRA
RFM
AFW
MAP
MSRH
AFIM
AKAT
AFMU
MFM
MFDB
MFZO
NFMN
BMS
Mean+SD
SEM
C.V.%
Range
RAZA 2 x 40 mg tablets
AUC 0-24 hr
(ng.hr/ml)
t max
(hr)
Cp max
(ng/ml)
AUC 0-24 hr
(ng.hr/ml)
t max
(hr)
Cp max
(ng/ml)
619.91
288.22
543.86
656.83
1061.56
648.85
854.81
485.21
297.61
705.57
566.16
734.11
583.34
476.81
246.57
393.08
1416.27
768.27
630.39
284.96
67.17
45.20
246.57
1416.27
1.6
0.97
0.5
1.03
0.98
0.58
1.12
2.07
2.13
1.00
1.03
2.00
0.77
1.62
1.50
1.53
1.48
1.55
1.30
0.49
0.12
37.55
0.5
2.07
97.01
124.86
102.18
120.73
173.67
134.24
156.18
81.89
42.89
104.61
92.18
129.46
136.51
51.24
43.31
70.67
265.03
147.94
115.26
53.41
12.59
46.34
43.31
265.03
664.55
367.65
483.73
323.26
693.33
487.79
741.36
530.42
239.49
870.05
497.93
716.22
1440.34
364.06
432.83
341.62
1505.53
740.04
635.57
351.01
82.74
55.23
323.26
1505.53
0.98
1.97
0.98
1.52
1.48
1.48
1.07
4.02
1.98
0.60
2.03
1.72
0.50
1.47
1.63
2.12
1.13
1.20
1.55
0.78
0.18
50.32
0.5
4.02
143.92
100.70
118.60
46.15
115.18
108.05
132.22
48.13
38.91
161.44
74.84
119.20
283.67
45.31
62.12
45.66
311.20
160.31
117.53
77.28
17
65.75
45.31
311.2
47
Bioequivalence of propranolol
Table 2.
Inderal)
AUC 0-24hr
ng.hr/ml
AUC 0-
ng.hr/ml
Cp max
ng/ml
t max hr
(Wilcoxon)
RAZA
Inderal
95% C.I
Sig (p)
NS
Powerofstudy
630.4285
635.6351
0.86-1.14
0.8053
NS
70%
670.2+299.2
685.0+350.2
0.87 1.11
0.9216
NS
80%
115.353.4
117.5 77.3
0.83 - 1.15
0.7058
NS
70%
1.3 0.5
1.60.8
NS
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