1

NAME________________________________________
MULTIPLE CHOICE QUESTIONS. CHOOSE THE BEST ANSWER.
___1. Oral chemotherapeutic drug that induces differentiation of leukemic
cells bearing t(15;17)
A. Cytarabine
C. Tretinoin
B. Methotrexate
D. Daunorubicin
___2. Morphologic FAB classification associated with disseminated
intravascular couagulation
A. M4
C. M2
B. M3
D. M5
___3. All four globin loci are deleted in what form of thalassemia
A. Homozygous thalassemia trait
B. Hemoglobin H disease
C. Heterozygous thalassemia trait
D. Hydrops fetalis
___4. Stage of Iron deficiency in which the demands for iron exceeds the
bodys ability to absorb iron from the diet
A. iron deficient erythropoiesis
C. iron deficiency
anemia
B. negative iron balance
D. Normal
___5. Serum ferritin level diagnostic of absent body iron stores
A. <100ug/L
C. <15ug/L
B. <30ug/L
D. <40ug/L
___6. Diagnostic test for Autoimmune Hemolytic Anemia
A.
B.
C.
D.

Antiglobulin test
Hemoglobin electrophoresis
Immunophenotyping
Osmotic fragility test

___ 7. Key iron regulatory hormone

A. Cubulin
Erythropoietin
B. Hepcidin

C.
D. Cortisol

___ 8. Peripheral blood smear finding in Cobalamin deficiency

A. marked microcytosis
C. presence of
schistocytes
B. hypersegmented neutrophils D. predominance of
myeloblasts
___9. AML cytogenetic abnormality associated with the development of
myeloid sarcomas
A. t(15;17)
C. t(8;21)
B. t(9;11)
D. t(14;18)

___10. Most common preceding infection associated with the development

of aplastic anemia
A. Parvovirus B19
C. Chlammydia
B. Schistosoma
D. Hepatitis
___11. True of the management of hemorrhagic manifestation in DIC
includes
A. Clotting factor concentrates are recommended for control of
bleeding
B. Transfusion must be adjusted according to the patients
clinical and laboratory evolution
C. Use of antifibrinolytic drugs is the cornerstone of treatment in
DIC
D. Platelet concentrate at a dose of 1u/kg is sufficient for DIC

___12. Single most common powerful predictor of survival in Multiple

Myeloma
A.
B.
C.
D.

Hemoglobin level
Presence of skeletal lytic lesions
Creatinine level
2 microglobulin level

___13. Laboratory findings in Thrombotic Thrombocytopenic Purpura EXCEPT:

A. Elevated indirect bilirubin
B. Elevated haptoglobin
C. Elevated reticulocyte count
D.Elevated LDH
___14. The following drugs carry a DEFINITE risk of clinical hemolysis in
persons with G6PD deficiency EXCEPT:
A. Chloramphenicol
B. Co-trimoxazole
C. Dapsone
D. Primaquine
___15. The following drugs are parenteral GPIIb/IIIa receptor antagonists
EXCEPT:
A. Abciximab
B.Argatroban
C. Ebtifibatide
D. Tirofiban

3
CASES. CHOOSE THE BEST ANSWER.
A.J. 24 year old male is a diagnosed case of mild haemophilia A who
presented in the emergency room in pain and was noted to have
hemarthroses on the Left Knee.
_____1. Initial management of AJ
A.
B.
C.
D.

request for an Inhibitor Assay

Screen for hepatitis C
Institute treatment with recombinant FVIII
Infuse synthetic vasopressin analogue

R.T. 27 year old female presented with multiple hematoma on the lower
extremities and fatigue in the emergency room. CBC done showed: Hgb
72g/l Hct 24 WBC 57,800 neutrophils =12 Lymphocyte=32 monocyte=1
blasts=55 platelet count=20,000/cumm
____2. Initial Impression
A. Chronic Leukemia
B. Acute Leukemia
C. Myelodysplastic syndrome
D. Idiopathic Myelofibrosis
Bone marrow aspiration was done as well as cytogentic studies which
revealed t(6;9), inv(3), and inv (16)
____3. Prognosis of patient RT
A. Good prognosis after treatment with cytarabine
B. Favorable response to Daunorubicin
C. Unfavorable due to the presence inv 16
D. Poor prognosis due to complex karyotye
E.H. 75 year old was diagnosed with Chronic Myelogenous Leukemia after
detection of BCR-ABL by FISH
____4. Treatment of Choice for E.H.
A. Imatinib besylate
B. Allogeneic marrow transplantation
C. Sunitinib
D. Busulfan
____5. Cytogenetic hallmark in patients with CML
A. t(8;21)
B. t(9;22)
C. t(15;17)
D. inv 3

4
After 6 months of treatment his CBC showed Hgb 87 Hct 29 WBC 15,000
neu 26 lym 10 mono 5 baso 22 eos 10 blast 2 myelocyte 11 promyelocyte
24 platelet count 95,000/cumm
____6. Patient is in what phase of CML?
A. normal phase
B. blastic phase
C. chronic phase
D. accelerated phase

RP, 56 year old male complains of headache. He is a non-smoker and is a

resident of Manila since childhood. Physical examination showed plethora ,
no cardiac murmurs,no organomegaly and essentially normal neurologic
evaluation. Complete Blood Count: Hgb 200g/dL, Hct 0.60 WBC 12.5x 10 9/l,
neutrophils 85% lymphocytes 15%, platelets: 575,000.
_____7. Mutation of this tyrosine kinase appears to have a central role in the
pathogenesis of poylcythemia vera
A. C-KIT
B. JAK2
C. PIG-A
D. PDGF
_____8. Symptoms distinguishing Polycythemia Vera from relative
erythrocytosis
A. tinnitus
B. digital ischemia
C. aquagenic pruritus
D. erythromelalgia
____9. RP frequently complains of severe joint pains of both big toes. Which
could he be suffering from as a complication of his blood problem?
A.
B.
C.
D.

Digital ischemia
Erythromelalgia
Gout
Thrombosis

____10. Most significant complication of Polycythemia vera

A. Infection
B. Bleeding
C. Thrombosis
D. Malignant degeneration

AV, 49 year old female presents with Left Upper Quadrant discomfort.
Physical examination showed the spleen to be enlarged measuring 20cm
below the left subcostal margin. CBC: Hgb 110 G/L Hct 0.36 WBC: 32x109/L
promyelocytes 15% metamyelocytes 20% myelocytes 10% bands 8%
segmenters 37% lymphocyte 10% platelets 650000. Peripheral smear
showed presence of tear-drop shaped cells and nucleated red blood cells.

____11. What is the most probable diagnosis of AV?

A.
B.
C.
D.

Acute Myelogenous Leukemia

Chronic Myelogenous Leukemia
Chronic Idiopathic Myelofibrosis
Hairy Cell Leukemia

_____12. Blood smear picture of extramedullary hematopoiesis

A. Absence of myelocytes and promyelocytes
B. Increased number of Howell Jolly bodies
C. presence of tear drop shaped cells
D. absence of nucleated RBCs

____13. What is the only curative treatment modality for AV?

A.
B.
C.
D.

Bone marrow transplantation

Danazol
Splenectomy
Thalidomide

F.O. 32 yo male is a diagnosed case of Aplastic Anemia based on bone

biopsy. He consulted at the ER because of fever. CBC done showed Hgb 62
Hct 19 WBC 0.8 neu 0.08, lym 0.92, platelet 40,000/uL retics:0.9%
___14. Major prognostic determinant in Aplastic Anemia
A. Cytogenetic findings
B. Age
C. Blood count
D. Spleen size
___15. Prognostic classification of F.O. based on his absolute neutrophilic
count
A. Stable disease
B. Severe disease
C. Very severe Disease

6
D. Progressive Disease
TRUE or FALSE.
1.

2.

Consistent with Complete Remission in Acute Myelogenous

Leukemia
__T___A. ANC >1000 with no circulating blasts
__F___B. hemoglobin >13g/dL
__T___C. platelet count >100,000u/L
Consistent with Chronic myelogenous Leukemia

__F___A. Typical bone marrow is hypercellular with >20% blasts

__T___B. WBC differential count shows myeloid cells in all stages of
differentiation
__T___C. Cytogenetic hallmark is the translocation between
chromosome 9 and 22
3.

Consistent with Multiple Myeloma

_F___A. Osteosclerosis
_T___B. Renal failure
_T___C. Hypercalcemia

4.

Mechanisms that results to thrombocytopenia

__T___A. sequestration
__T___B. increased destruction
__T___C. decreased bone marrow production

5.

Secondary causes of ITP

__T___A. HIV infection
__T___B. Systemic Lupus Erythematosus
__F___C. Paroxysmal Nocturnal Hemoglobinuria

6.

Laboratory Findings found in Thrombotic Thrombocytopenic

Purpura
__F__A. Increased haptoglobin
__F__B. Positive Coombs Test
__T__C. Increased LDH

7.

Laboratory Findings in patients with Hemophilia

__T__A. Normal Bleeding time
__F__B. Prolonged Prothrombin Time

7
__T__C. Prolonged Activated Partial Thromboplastin Time
8.

General Features of Hemolytic Disorders

__F___A. Decreased Bilirubin
__F___B. Low Reticulocyte count
__T___C. Decreased Haptoglobin levels

9.

True of Autoimmune Hemolytic Anemia

__T___A. Diagnostic Test is the Antiglobulin test
__T___B. May be the first presentation of SLE
__F___C. First line treatment is Rituximab

10. Features of Polycythemia Vera

__T__A. Positive JAK-2 mutation
__T__B. Thrombosis is the most significant complication
__F__C. Arterial oxygen saturation is abnormal