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.


E-mail: cdalla@med.uoa.gr





(PDD)

:
: 4 / 2 2020 (20%)
: 2/1 /

*
*

2010
30.300.000


2/3
.

*
ECNP/ECB report 2010

Stahl, S. M., 2000. In: Essential Psychopharmacology of Depression and Bipolar Disorder

:


(TCA)

, , , , , ,
, , ,

(MAO)

, , , ,


(SSRIs)
, , , ,

(SNaRIs)
, ,

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,


, , , , ,

X
: , ,

: K ,
,
, ,
( SnRI)
(SSRIs)
(SSRIs)
(ADHD) ()
/ ( SSRI)
, ( SnRI)


(1954,
).
,
60-70% .
()



(5-)
()

(1965)
( )
/
5-

:


:
(),
(5-)
(DA)

5- ,



, 5-

5-

2- 3

Glutamate

5-HT

NA

BDNFTrkB

AC

Ras
Raf
MEK

NMDA R

Ca2+

PLC

cAMP
CaMK

PKC

PI-3K

Akt
Erk

PKA

RsK
P
CREB

BDNF
Bcl2


--
: ,
-

: , ,
, ,
, ,
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, ,
,

Imipramine



(1, 1, 1, + Ca2+ )
(1): , , , ,
,
(1): , ,
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( +), ( 1 2), ,

/
3 , , , ,
, ,


-
( ). 1- 3
. .
( )
: , , ,


.
: Parkinson -

- (RIMAs):
, ,

( - )


(SSRIs)
, , , ,

S-


(SSRIs)
H
1986.
1/2 16-24hrs
(: 8
)

Tryptophan
5-OHtryptamine
5-HTT

Serotonin


(5),

24 (
70% )

5-HT1A
5-HT2A/C

5-HT2A/C
5-HT1A


(SSRIs)
:
.
P450-2D6 (, ),
.
: , ,
.
.
.
.
:
.
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:
,
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,
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, ()
(SSRI, MAOIs ..),
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), 5-T1 (), ,
.

SSRIs
SSRIs





.

5-HT
(SNRIs)
(XR),
( 5-)
1,
/

, , .
(): ,
, , , , ,
, ,
IR 1/2
XR

2 5- :
/
,
5-2 5-
: ,
( 7-12 .,
XR)
DA (NDRIs)
: , , ,


(MT1, 2) 5-2

~ 4%
-
: >14H, / ,
(, , )

Stahl, S. M., In: Essential Psychopharmacology of Depression and Bipolar Disorder



: Antonin Arteaux, Charles Baudelaire, Robert Burns, Lord Byron, Emily
Dickinson, T.S. Eliot, Friedrich Hlderlin, Victor Hugo, Samuel Johnson, John Keats,
Vladimir Mayakovsky, Boris Pasternak, Sylvia Plath, Cesare Pavese, Edgar Allan
Poe, Ezra Pound, Alexander Pushkin, Lord Tennyson, Dylan Thomas,Walt Whitman
: Hans Christian Andersen, Honor de Balzac, Joseph Conrad, Charles
Dickens, William Faulkner, Nikolai Gogol, Maxim Gorky, Graham Greene, Ernest
Hemingway, Herman Hesse, Henrik Ibsen, Henry James, Herman Melville, Eugene
O Neal, Mary Shelley, R. L. Stevenson, August Strinberg, Leo Tolstoy, Tennessee
Williams, Virginia Woolf, Emile Zola,
-: Hector Berlioz, Edward Elgar, G.F. Haendel, Gustav
Mahler, Charles Mingus, Charlie Parker, Cole Porter, Sergey Rachmaninoff, G.
Rosini, Robert Schumann, Peter Tchaikovsky
: Richard Dadd, Paul Gaugin, Vincent van Gogh, E.L. Kirchner,
Michelangelo, Edvard Munch, Jackson Pollock

,




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60-80% .
. . .
95%.
( )
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(Therapeutic drug monitoring): 0,7-1,0 mmol/L
( >1,2~1,5). .

(.. +)

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IP3, glycogen synthase kinase-3

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+
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