RBCs, hemolysis (RBC destruction), clumping together of RBCs which can block small
blood vessels leading to renal failure, and sometimes death.
Rh negative patients can receive on first blood transfusion from a donor with Rh
positive blood without harm as the patients blood plasma doesnt have antibodies
to react with the incoming donors RBCs antigen; but the second transfusion may
be dangerous because the patients blood plasma developed anti-Rh-antibodies.
Blood with Rh negative can be transfused into Rh positive patients in any
number of times without harm.
Often Rh negative pregnant woman carries a fetus with a different Rh blood type to
herself (Rh positive fetus) and sometime after the second succeeding pregnancy
with a Rh positive fetus; the mother with Rh-negative forms antibodies (anti-Rhantibodies) and attack the blood of an Rh-positive fetus in her second pregnancy.
The mothers Rh antibodies destroy some of the fetal red blood cells which cause
hemolytic anemia (hemolytic disease), where red blood cells of the fetus are
destroyed faster than the body can replace them. Severe hemolytic anemia may
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even be fatal to the fetus. This condition is also known as erythroblastosis fetalis
or Rh disease.
As they are TOO LARGE to pass through capillaries, interstitial fluid or tissue fluid does
not consist of:
- plasma proteins ( albumin, fibrinogen, globulin )
- erythrocytes
- platelets
Importance of interstitial fluid:
a. Important to cell because through this fluid that exchanges material between
blood capillaries & cells occurs
b. Nutrient & oxygen diffuse through interstitial fluid into body cells.
c. Carbon Dioxide and waste product diffuse through interstitial fluid into the
blood.
What is lymph?
Interstitial fluid that is not absorbed back to the bloodstream drains into the LYMPH
CAPILLARIES. This collected fluid is known as Lymph. Lymph is a transparent
yellowish fluid.
Lymph also contains tiny droplets of lipids.
-The intestinal lining of the small intestine is covered by villi
-villi contain lacteals
-lacteals are lymph capillaries (droplets of lipid and fat-soluble vitamins are transported
to the bloodstream)
Lymph capillaries collects excess interstitial fluid from the spaces of the cells in a form
of a yellow fluid known as lymph fluid as the lymph capillaries unite to form lymphatic
vessels (lymph vessels).
Lymphatic vessels have valves to:
1. Ensure the continues flow of the lymph away from the tissues
2. Prevent back flow of the lymph fluid
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Lymphatic system does not have its pumps to move the lymph fluid around through the
lymphatic vessels. It moves to the subclavian veins with the help of:1. One-way valves,
2. Muscular contraction
3. Intestinal movements, and
4. Pressure changes that occur during inhalation& exhalation.
This system allows the lymph fluid to pass through the lymph nodes.
Lymph fluid flows into lymph nodes through AFFERENT lymphatic vessels and after
filtration of the lymph fluid, it passes out of the lymph nodes through EFFERENT
lymphatic vessels.
Lymph nodes are oval shaped gland-like structure resemble like seeds, range in size
from 1-25mm in length and found at intervals along the lymphatic vessels.
o Lymph nodes filter microbes and other foreign particles out of the lymph fluid
and then destroy them.
o Lymph nodes store and produce White Blood Cells, e.g. Lymphocytes
o Lymph nodes are important part of the defense system; they defend the body
against infection.
o Lymph nodes often swell up in times of infections.
Lymph nodes are found at the armpits, the neck, back of the knees, and the
groin.
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From the lymphatic vessels, lymph will eventually passes one of two main
channels which are either.
a) Thoracic duct, or
b) Right lymphatic duct.
The following diagram shows the relationship between lymphatic system and circulatory.
3 The process is crucial because water, nutrients and other molecules continuously
leak out of blood capillaries into the surrounding body tissues.
If interstitial fluids not returned to the circulatory system, will cause:
swollen of body tissues ( because too much fluid is retained)
Oedema ( condition of excessive accumulation of interstitial fluid in the spaces
between the cells, cause by a blocked lymphatic vessel)
Major Lymphatic Organs (Lymphoid Organs):
1. Tonsils:
2. Thymus Gland:
3. Spleen:
.
The walls of lymph capillaries are more permeable than the walls of the blood
capillaries, so large molecules such as fats can pass through them.
Not all of the tissue fluid returns to the blood capillary, only 90% of the tissue
fluid carrying carbon dioxide moves back into the capillaries under the process
of osmotic pressure, while the remaining 10% of the tissue fluid in the form
of lymph fluid enters a separate system of capillaries called the lymph
capillaries which are part of the lymph system.
T-lymphocytes initially pass to the thymus (a lymph gland in the neck) where
they are activated (thymus gland develops mature T-lymphocytes).
T-lymphocytes then migrate to the spleen and lymph nodes where they are
stored to. T-lymphocytes recognize and attack a particular type of antigen.
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