22 - 224CPD-Steroid Dementia Syndrome Sebagai Salah Satu Komplikasi Cushing Syndrome
22 - 224CPD-Steroid Dementia Syndrome Sebagai Salah Satu Komplikasi Cushing Syndrome
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CONTINUING
DEVELOPMENT
PROFESSIONAL
MEDICAL
DEVELOPMENT
EDUCATION
ABSTRAK
Cushing Syndrome adalah kumpulan gejala dan tanda akibat pajanan berkepanjangan hormon glucocorticoid dalam kadar tinggi, yang dapat
terjadi endogen atau eksogen. Salah satu komplikasi Cushing Syndrome adalah menurunnya beberapa aspek kemampuan kognitif, seperti
daya ingat, atensi, dan kemampuan verbal, karena proses perubahan struktural otak akibat pajanan glucocorticoid. Tulisan ini akan membahas
komplikasi Cushing Syndrome terhadap proses kognitif atau dikenal sebagai steroid dementia syndrome.
Kata kunci: Cushing Syndrome, demensia, kognitif, daya ingat, atensi
ABSTRACT
Cushing Syndrome is a group of symptoms and signs caused by prolonged exposure to elevated level glucocorticoid hormone, from
endogenous or exogenous sources. One of the possible Cushing Syndrome complication is cognitive decline, especially memory, attention,
and verbal performance, due to structural changes in the brain after glucocorticoid exposure. This review will discuss Cushing Syndrome effects
to cognitive process or known as steroid dementia syndrome. Dony Prihartanto. Steroid Dementia Syndrome as a Complication of
Cushing Syndrome
Keywords: Cushing Syndrome, dementia, cognitive, memory, attention
Cushing Syndrome
Harvey Cushing, seorang dokter bedah
saraf yang mendapat gelar sebagai Father
of Modern Neurosurgery dari AS dalam
bukunya The Pituitary Body and its Disorders
pada tahun 1910 pertama kali melaporkan
seorang wanita dengan sebuah sindrom
yang ditandai oleh obesitas sentral, striae
abdomen, hirsutisme, amenore, hipertensi,
kelemahan otot proksimal, penipisan rambut,
dan purpura.1 Saat ini Cushing Syndrome
telah dikenal sebagai sindrom akibat pajanan
sistemik berlebihan hormon glucocorticoid.
Penyebab utama adalah pajanan eksogen
hormon glucocorticoid dari obat yang
diminum pasien. Penyebab lain adalah
pajanan glucocorticoid endogen. Cushing
Syndrome endogen adalah penyakit yang
jarang dengan insiden 1,8 - 2,4 kejadian /
1 juta / tahun. Di antara penyebab Cushing
Alamat korespondensi
Tanda
Penyerta
Depresi
Mudah Memar
Hipertensi
Fatigue
Acne
Osteoporosis Vertebral
Diabetes tipe 2
Nyeri punggung
Striae
Hipokalemia
Lemak Dorsoservikal
Batu Ginjal
Penurunan Konsentrasi
Sering Infeksi
Penurunan Libido
Obesitas
Insomnia
Iritabilitas
Dismenore
Kulit Tipis
Pertumbuhan Terhambat
Tubuh Pendek
Hormone). 2 Baik
Cushing
Syndrome
endogen maupun eksogen memiliki gejala
yang serupa.
email: dokdonee30@gmail.com
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Tabel 2 Perbandingan Skor WAIS-R verbal IQ, WAIS-R performance IQ dan WMS memory quotient antara kelompok Cushing
dengan kontrol8
Kontrol
Cushing
nilai P
WAIS-R verbal IQ
106,2
96,2
p < 0,001
WAIS-R performance IQ
108,4
97,7
p < 0,0001
119,3
104,2
p < 0,0001
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