Mechanisms and
management of normal
labour
Tara Selman
Tracey Johnston
Abstract
It is essential that those providing antenatal and intrapartum care understand what constitutes normal labour. This allows complications that can
arise at any stage to be recognized early and can help prevent serious
sequelae. This review covers the physiology, mechanisms and evidence
based management of normal labour.
Term is the end of normal gestation in humans; the range for this
is 37e42 completed weeks. Although the estimated date of delivery (EDD) is 280 days from the first day of the last menstrual
period, only 3e5% of women deliver on their EDD. Labour is
defined as regular, painful uterine contractions leading to progressive effacement and dilation of the cervix from 4 cm dilatation. Towards the end of pregnancy, during what is described as
pre-labour, the tissues of the cervix undergo fundamental
physiological and structural changes, resulting in a marked
reduction in tensile strength. It is this process of cervical ripening
that converts the cervix into a soft, yielding structure that offers
little resistance to the expulsive forces of the myometrium during
labour. This process of cervical ripening is parallelled during prelabour by an increase in the spontaneous contractility of the
myometrium. The BraxtoneHicks contractions that are present
throughout pregnancy increase exponentially in frequency and
amplitude, reaching a peak during labour per se. The stimulus for
the complex changes that result in labour are largely unknown.
What is clear is there that is a complex interplay between
maternal, fetal and placental factors.
Cervix
The main component of the cervix is collagen, along with some
smooth muscle and elastin, all embedded in a connective tissue
Hormones
Maternal: progesterone is so called as it supports pregnancy. It is
made by the corpus luteum until approximately 7e8 weeks
gestation and subsequent to this is produced by the placenta.
Progesterone is known to have potent anti-inflammatory properties, and antiprogestins have been demonstrated to effectively
induce cervical ripening. Progesterone has an inhibitory effect on
contractile proteins via its ability to block the formation of gap
junctions. It also decreases prostaglandin production and inhibits
oxytocin release and the formation of oxytocin receptors.
Although there is no systematic decrease in progesterone with
advancing gestation, there is a decrease in the number of
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vertex position and ending with the mother and fetus in good
condition following a spontaneous delivery. In the UK almost
90% of women will give birth to a single baby after 37 weeks of
pregnancy with the baby presenting head first and two thirds go
into labour spontaneously. Labour is traditionally divided into
three stages of unequal length.
First stage
This stage is divided into the latent and active phase. The latent
phase in when there are painful contractions and cervical change
including effacement (shortening of the cervix to less that 0.5
cm); these changes may not necessarily be continuous. The
active phase is characterized by regular painful contractions and
progressive cervical dilation from 4 cm. The length of the active
phase varies between nulliparous and multiparous women. First
labours last an average of 8 h and are unlikely to last over 18 h
and subsequent labours last on average 5 h and are unlikely to
last over 12 h.
Second stage
The second stage of labour begins at full dilation and ends with
the delivery of the baby. This stage has two phases; an initial
passive phase which beings at full dilation prior to or in the
absence of involuntary expulsive efforts, and an active phase, the
onset of which is defined as the baby being visible, expulsive
contractions with a finding of full cervical dilation or active
maternal effort following confirmation of full cervical dilation in
the absence of expulsive contractions. The duration of second
stage is variable and again varies with parity. For nulliparous
women, birth should be expected to take place within 3 h of the
start of the active stage and for multiparous women 2 h. An
unduly prolonged second stage is associated with adverse
maternal and fetal outcome. The pH of the fetal blood decreases
during the second stage and therefore if the fetus is already
compromised when pushing commences, hypoxia can occur. An
excessively prolonged second stage can be associated with urinary tract damage and vesicovaginal fistula formation.
Third stage
The third stage of labour is the time from the birth of the baby to
the expulsion of the placenta and membranes. Signs of spontaneous separation of placenta include a gush of vaginal blood,
lengthening of the umbilical cord and a rise in the uterine fundus.
The commonest complication of the third stage is haemorrhage,
but this is significantly reduced by active management, which
has been shown to reduce the incidence of blood loss greater
than 500 ml from 15% to 5%. Active management of the third
stage involves three components; firstly the routine use of a
uterotonic drug, the most commonly used oxytocic agents either
Syntocinon 5 iu or Syntometrine (Syntocinon 5 iu and ergometrine 0.5 mg). Secondly, early clamping and cutting of the cord.
Thirdly, controlled cord traction; gentle cord traction is applied
while guarding the fundus to deliver the placenta and membranes once signs of separation have been seen. Even with active
management, studies indicate that there should be a delay in
clamping of the cord of over a minute to increase neonatal iron
stores at 4 months, this does not increase maternal complications. The third stage should be completed within 30 min of birth
of the baby with active management and within 90 min with
Normal labour
The WHO (World Health Organisation) defines normal labour as
low risk throughout, spontaneous in onset, with the fetus in
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Other mechanisms
Other mechanisms occur with malposition of the fetus. With right
or left occipitoposterior positions at the onset of labour, rotation to
an occipitoanterior position usually occurs before delivery. A
direct occipitoposterior position is associated with an occipitofrontal diameter of 11.5 cm and often a long dysfunctional labour.
Also, because this diameter is wider than the conventional suboccipitobregmatic diameter it is associated with relative cephalopelvic disproportion. If vaginal delivery occurs, the sinciput
emerges from under the symphysis pubis. Some occipitoposterior
positions arrest during internal rotation in an occipitotransverse
position, which can rarely be delivered spontaneously. A face
presentation results if extension rather than flexion occurs in early
labour. The face presentation continues to descend with increasing
extension when the chin reaches the pelvic floor. If rotation to a
mentoanterior position occurs, delivery can occur by flexion of the
neck. If the internal rotation results in a mentoposterior position,
the chin lies in the hollow of the sacrum and there is no mechanism
for delivery of the baby vaginally as the fetal neck can extend no
further. If extension is incomplete, a brow presentation may occur,
which is associated with a mentovetical diameter of 13.5 cm. A
brow presentation is unstable; most convert to a deflexed vertex or,
occasionally a face presentation by full dilatation. If the brow
persists at full dilation, there is usually cephalopelvic disproportion and delivery should be undertaken by caesarean section unless the baby is small (e.g. preterm, second twin), in which case
successful vaginal delivery can be achieved.
The mechanism of labour for breech presentation involves
descent, internal rotation of the buttocks and descent of the
bitrochanteric diameter in the anteroposterior diameter. The hip
is delivered under the symphysis pubis by lateral flexion of the
body and restitution occurs once the posterior buttock is delivered. Internal rotation of the shoulders occurs as the sacrum
rotates anteriorly, and the head descends into the pelvis with the
sagittal suture in the transverse diameter. The head undergoes
internal rotation and is delivered with flexion of the neck.
Rotation to sacroposterior after delivery of the body leads to
difficulty in delivery of the head and should be prevented.
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Management of labour
heart rate is abnormal (greater than 160 bpm, less than 110 bpm or
declarations after a contraction), in the presence of a maternal
pyrexia, fresh vaginal bleeding, if oxytocin is to be used, or finally if
the mother requests it.
Passenger
The progress of labour is influenced by fetal size and position.
Abdominal palpation should be performed to assess the descent
of the presenting part. Cervical assessment also provides information about the station of the presenting part in relation to the
ischial spines. The development of caput and moulding are
important, as these may be indicators of disproportion.
Passages
Abnormality of the bony pelvis may cause a delay in the progress
of labour. With improvements in maternal nutrition, such abnormalities are less common than in the past. Cephalopelvic
disproportion may occur between a macrosomic fetal head and a
pelvis of normal proportions. Relative cephalopelvic disproportion can occur when a wider diameter of the fetal head is trying
to negotiate the normal pelvic diameters, as in malposition. A
rigid perineum can occasionally lead to delay in delivery, and the
situation regarding the need for episiotomy should be assessed
by an experienced midwife.
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Posture in labour
An environment helpful to the mother may include ample space
and the use of aids such as birth pool, mats on the floor, cushions, rocking chair and gym balls. Changes to position may help
labour progress. Women should be discouraged from lying supine or semi-supine in the second stage of labour as this is
associated with delay and an increased incidence of instrumental
delivery. They should be encouraged to adopt any other position
they find most comfortable as long as fetal well-being can be
confirmed. Squatting increases the pelvic diameter by 8 mm and
is similar to McRoberts manoeuvre employed in the management of shoulder dystocia.
A
FURTHER READING
Birthplace in England Collaborative Group. Perinatal and maternal outcomes by planned place of birth for healthy women with low risk
pregnancies: the Birthplace in England national prospective cohort
study. BMJ 2011; 343: d7400.
Intrapartum care. NICE clinical guidelines September 2007.
Philpot RH. Graphical records in labour. BMJ 1979; IV: 163e5.
Rogers D, Wood J, McCandish R, Ayres S, Truesdale A, Elsborne P. Active
management versus expectant management of the third stage of labour:
the Hinchingbrooke randomised control trial. Lancet 1998; 351: 693e9.
Steer P, Flint C. ABC of labour care. Physiology and management of
normal labour. BMJ 1999; 218: 793e6.
Weeks AD, Alia G, Vernon G, Namayanja A, et al. Umbilical vein oxytocin
for the treatment of retained placenta (release study): a double-blind,
randomised controlled trial. Lancet 2010; 375: 141e7.
Practice points
Pain relief
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