What are the different types of stem cell transplants performed by DIAD?
Transplant Source of Stem Cells
Autologous. The patient
Allogeneic Matched sibling
Syngeneic Identical twin
* The type of transplant is determined by the autoimmune disease being treated.
What is a conditioning regimen?
For stem cell transplants performed by DIAD, the conditioning regimen involves chemotherapy and
immunosuppressant drugs that target components of the immune system.
What is neutropenia?
Neutropenia means low neutrophil count. Neutrophils are a type of white blood cell responsible for
fighting infections. Chemotherapy will cause a reduction in neutrophil count.
What is the difference between myeloablative and non-myeloablative therapy?
Myeloablative and non-myeloablative refers to the potency of the drugs and treatments that are
used to eradicate the bone marrow cells.
- Myeloablative: The use of a conditioning regimen usually reserved for cancer therapy that
causes complete destruction to the stem cell compartment. A stem cell transplant is
necessary for recovery and survival.
- Non-myeloablative: The use of a conditioning regimen that removes much of the immune
system, however, recovery will occur without stem cell transplant.
What are the advantages of using a non-myeloablative conditioning regimen?
- Fewer side effects
- Faster recovery
- Less risk of serious infections
- Less risk of transplant related complications and mortality
- Less risk of developing treatment related cancers later
- Uses a conditioning regimen in which the bone marrow will recover without the infusion of
stem cells
Pre-Transplant Testing
Mobilization
Harvest
Day 0
Stem cells are thawed and infused through
the PICC line in hospital room
Takes approximately 30 minutes
Day +1 to engraftment
White blood cells, red blood cells, and
platelets will decrease
Blood transfusions may be required
IV antibiotics given
Daily lab draws
Engraftment
Diseases Treated
Autologous
Multiple Sclerosis
CIDP
Systemic Sclerosis
Devics
Stiff Person Syndrome
Crohns Disease
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Vasculitis
Polymyositis
Allogeneic
(Matched Sibling)
Crohns Disease
Rheumatoid Arthritis
Vasculitis
Systemic Lupus Erythematosus
Pansclerotic Morphea