UNIVERSITI MALAYSIA PERLIS (UniMAP)

SCHOOL OF BIOPROCESS ENGINEERING

SEMESTER 2, ACEDEMIC SESSION 2015/2016

INTEGRATED PROJECT
ERT320 Bio-Separation Engineering,
ERT321 Process Control & Dynamics,
ERT314 Bioreactor System &
ERT323 Simulation for Bioprocess Engineering

FINAL REPORT
DATE OF SUBMISSION: 25TH MAY 2016

TITLE: PRODUCTION OF BIO-PRODUCTS FROM

Oennococcus Sp.
SUPERVISOR: EN MUHAMMAD FAIQ ABDULLAH
GROUP MEMBERS:
NAME:
WONG SOON THIAN
LUM LI LIAN
MUHAMMAD SHAFIZUL NAIM BIN ABDULLAH
AINON BINTI MD. NOR

MATRIX ID:
131142846
131140873
131141459
131140119

TABLE OF CONTENTS:
No
1.0

Contents
Introduction

Page
1

1.1

Background Of The Project

1-7

1.2

Block Flow Diagram

1.3

Process Flow Diagram (PFD)

1.4

Product Description

10-12

1.5

Process Description

13-23

1.6

Marketibility

24-27

2.0
2.1
2.2

ERT314 Bioreactor System

Identify the types of products and biological systems.
Propose the media formulation for fermentation or

28-29
30-31

process required according to nutritional requirements

2.3

for growth and product formation

Propose the most suitable bioreactor for the desired

32-38

product formation and design the bioreactor according

to the Reynolds number, power input, oxygen transfer
2.4
3.0
3.1

rate and etc.

Examine part 1.1, 1.2 , 1.3 in Discussion Part.
ERT320 Bio-Separation Engineering
Identify the types of desired product (Intra, Extra or

39-40
41-42

whole cell). Apply the rules of thumb for the process of

3.2

bio-separation.
Identify the industrial applications (eg. Pharmaceutical,

43-46

food, therapeutics, etc) and propose the RIPP scheme

for the desired products (block and flow diagrams of the
3.3

downstream processing).
Calculate the recovery (eg. concentrations, purity,

47-50

and/or efficiency) for each of the unit operation in bio3.4

separation process.
Design ONE (1) unit operation only in the downstream

51-53

process (eg. ultrafiltration, sedimentation,

3.5

centrifugation, chromatography, etc).

Examine part 2.1, 2.2, 2.3, in Discussion Part.

54-57

4.0
4.1

ERT321 Process Control

& Dynamics
Identify the parameter(s) that need to be controlled in

58-69

each operation unit and write the control objective.

Hence, determine the controlled variable (CV),
manipulated variable (MV) & disturbance variable
4.2

(DV), and propose the suitable control structure(s).

Derive dynamic models of processes for ONE unit

70-73

operation in your plant using mass balance and energy

balance. From your dynamic models, develop transfer
functions to relate the changes in input variables to the
4.3

changes in output variables. State all assumptions.

If a feedback control system with a proportional

74-76

controller is used in part b, propose a range of

proportional gain values, Kc that result in a stable
4.4

closed-loop system, assuming Gm =1 and Gv = 1.

Simulate open-loop and closed-loop systems as derived

77

in part b) and c), respectively using Matlab-Simulink

4.5

software.
Develop a Process & Instrumentation Diagram (P&ID)

78

5.0
5.1
5.2

of your plant using Microsoft Visio.

ERT323 Simulation for Bioprocess Engineering
Determine the objectives of the Case Design.
Write literature review (description of method

79
79-82

(including flow chart), literature on the case study to

5.3

support your case design etc.)

Develop a process flow diagram for the production

83-93

5.4

using SuperPro.
Discus on economic review, debottlenecking,

94-98

6.0
7.0

throughput analysis and suggestions.

Conclusion
Appendix

99-100
101