Abstract
Obstetric critical illnesses represent a small but important proportion of
all intensive care unit (ICU) admissions in the UK. They are challenging
to the critical care team because of the unique physiology and specific
medical disorders seen in this population. Maternal mortality is fortunately rare, but devastating when it occurs, with the commonest causes
of death being cardiac disease and venous thromboembolism. Massive
obstetric haemorrhage, pre-eclampsia and genital tract sepsis are also
important causes, and these are reflected in the reasons for ICU admission in the obstetric population. Maternal mortality may be reduced by
prompt recognition of critical illness in the pregnant woman, earlier initiation of intensive care, and increased input from senior clinicians.
ICU management involves resuscitation, monitoring \and assessment
of deranged physiology, and the provision of safe organ support. The
overall aims are to ensure adequate oxygen delivery and tissue perfusion,
and to stabilise the patient while awaiting investigations which may guide
further disease-specific management. The normal physiological adaptations to pregnancy and the effects of any drugs or procedures on the
fetus should be taken into account.
Introduction
In the UK, less than 2% of ICU admissions relate to obstetric
illnesses, compared to up to 10% in the developing world. Of these
admissions, 50e80% relate to a direct obstetric cause (Table 1),
and the remainder to medical or surgical causes, with pregnancy
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Obstetric conditions in the Intensive Care National Audit and Research Centre (ICNARC) Coding Method
Haemorrhage
Hypertensive disorder
Other conditions
Antepartum haemorrhage
Peripartum or postpartum haemorrhage
HELLP syndrome
Pre-eclampsia
Eclampsia
Ectopic pregnancy
Amnionitis
Infected retained products of conception
Septic abortion
Intrauterine death
Molar pregnancy
Amniotic fluid embolus
Table 1
recommendations about ICU management including the adherence to major haemorrhage protocols, early identification and
targeted management of sepsis, and increased resuscitation
training of all obstetric staff. Forward planning for high-risk cases
should involve all multidisciplinary team members, and elective
ICU beds should be booked accordingly. Critical care can often be
initiated in the operating theatre or emergency department prior
A&B
No fetal risk in humans
C
Studies inconclusive. Use
when benefit outweighs risk
D
Evidence of fetal risk but
benefit may outweigh risk
X
Contraindicated in
pregnancy: risk outweighs
any benefit
Cardiovascular
Dobutamine
Methyldopa
Analgesic/sedatives
NSAIDS
(1st & 2nd trimesters)
Acyclovir
Cephalosporins
Clindamycin
Macrolides
Penicillins
e
Insulin
Magnesium sulphate
Diazepam
Midazolam
NSAIDS (3rd trimester)
e
Antibiotics
Adenosine
Digoxin
Dopamine
Epinephrine
Norepinephrine
Glyceryl trinatrate
Hydralazine
Milrinone
Nifedipine
Fentanyl
Morphine
Haloperidol
Aminoglycosides
Quinolones (1st trimester)
Trimethoprim (in 1st trimester)
Vancomycin
Heparin
Glucocorticoids
Neuromuscular blockers
e
e
Warfarin
e
Anticoagulants
Other
Abbreviations: FDA, Food & Drug Administration; ACEI, angiotensin converting enzyme inhibitors; ARB, angiotensin receptor blockers; NSAIDS, non-steroidal antiinflammatory drugs.
Table 2
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Respiratory
FRC reduced
O2 desaturation more common
COP reduced
HR, heart rate; SVR, systemic vascular resistance; PVR, pulmonary vascular resistance; CVP, central venous pressure; COP, colloid oncotic pressure; FRC, functional
residual capacity.
Table 3a
Renal
Gastrointestinal/liver
Hydronephrosis
Increased renal plasma flow, glomerular filtration rate, and
creatinine clearance
Proteinuria (<300 mg/24 h)
Reduced excretion of sodium and water load with resultant peripheral oedema
Table 3b
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Cardiovascular
Cardiovascular support may involve fluid administration (e.g.
crystalloids, colloids and blood products), correction of cardiac
rhythm and electrolyte disturbances, use of inotropes (e.g.
dobutamine, milrinone) and vasopressors (e.g. norepinephrine)
and ventilatory support. The concept of a fluid challenge to
determine a patients fluid status is similar to that in a nonpregnant setting. Fluid therapy in obstetrics should be more
cautious than in the non-obstetric setting because of the
increased risk of pulmonary oedema, especially in patients with
pre-eclampsia.
Invasive monitoring may involve central venous pressure
(CVP) monitoring to assess intravascular volume and cardiac
output (CO) monitoring. Methods for measuring the CO include
pulsed continuous cardiac output (PiCCO), lithium dilution
cardiac output (LiDCO), oesophageal Doppler, and rarely the
pulmonary artery catheter.
Gastrointestinal
Nutritional support is usually required to avoid the complications of malnutrition such as impaired wound healing and
immune function. The enteral route is preferred, using a nasogastric or nasojejunal tube, or occasionally surgical gastrostomy or jejunostomy. Prokinetic agents (such as
metoclopramide or erythromycin) facilitate gastric emptying
and are safe in pregnancy. Sometimes total parenteral nutrition
(TPN) is required via a central venous line, but complications
include line-related sepsis, thrombosis and suppressed T-cell
immunity. Stress ulceration and gastrointestinal bleeding are
reduced by early enteral feeding, however, proton pump
inhibitor prophylaxis is required if patients are not able to be
fed. Avoiding hyperglycaemia has been shown to improve
outcome (see below).
Neurological
Neurological support aims to relieve pain and anxiety, and
prevent secondary brain injury following an initial insult. The
level of sedation required will depend on factors such as the
ventilation mode and need for invasive procedures. Drugs used
include analgesics (paracetamol, opiates) and sedative-anxiolytics (benzodiazepines, propofol, haloperidol, and clonidine).
Sometimes patients will also require neuromuscular blockade,
for example, to facilitate ventilation in ARDS and for initial
intubation. Avoiding oversedation and reviewing the need for
sedation at least on a daily basis is imperative.
Respiratory
As well as enhancing oxygen delivery to the tissues with
supplemental oxygen therapy, respiratory support ensures
effective removal of CO2 by either invasive or non-invasive
ventilation (NIV). NIV includes the use of continuous positive
airway pressure (CPAP) and also bi-level pressure support. In
certain settings, for example pulmonary oedema, NIV is a very
effective as first-line treatment, but requires haemodynamic
stability and no severe acidebase disturbance.
Invasive ventilation is indicated in patients with more severe
respiratory failure such as in ALI/ARDS, and a protective lung
strategy should be employed. This strategy involves optimizing
alveolar recruitment and oxygenation, while avoiding pressureinduced lung damage (barotrauma) or over-distension (volutrauma). This necessitates using low tidal volumes (6e8 ml/kg)
and low peak inspiratory pressures (<30 cmH2O). The inspired
oxygen (FiO2) should be reduced to less than 0.7 as soon as
possible. Hypercarbia often results, which is usually well tolerated if the patient is optimally sedated. The effects of a markedly
increased PaCO2 on fetal wellbeing are not clear; however they
are likely to be detrimental with acidosis leading to reduced
ability of fetal haemoglobin to bind oxygen.
Monitoring may involve measurement of arterial blood gases,
pulse oximetry, central venous oxygen saturation (ScvO2) and
blood lactate as a measure of oxygen delivery and global tissue
perfusion. An indication of oxygenation is calculated using ratio
of partial pressure of oxygen (PaO2)/fractional inspired oxygen
(FiO2), the P/F ratio.
Renal
Early recognition and appropriate management of renal impairment and oliguria is important to avoid the development of acute
kidney injury (AKI). Management will depend on the underlying
cause, but involves careful fluid administration with a fluid
challenge where appropriate, diuretics, correction of electrolyte
imbalances, inotropes, and specific measures to treat the
underlying cause (e.g. antibiotics for sepsis). Low-dose renal
dopamine has no proven benefit. In established AKI, renal
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Severe hypoxaemia
P/F ratio <200 mm Hg (or 27 kPa)
Major haemorrhage
Sepsis
Intrauterine fetal death
Hypertensive disease
Preeclampsia
Eclampsia
Acute fatty liver of pregnancy
Table 4
There are two main types of shock: either warm and dilated
or cold and clammy. Patients with warm and dilated shock, as
seen in early sepsis or anaphylaxis, are peripherally vasodilated
[low systemic vascular resistance (SVR)] with a high CO, they
may have a bounding pulse and are flushed. Conversely, patients
with cold and clammy shock, as in hypovolaemia or cardiogenic shock, are peripherally vasoconstricted (high SVR) with
a low CO, so will be shutdown with a low volume pulse. The
jugular venous pressure (JVP) or CVP may help determine the
cause, as it is often high in cardiogenic and obstructive shock,
and low in hypovolaemic and anaphylactic shock, but can be
high, low or normal in septic shock. Patients do not always
follow these rules though, especially young obstetric patients,
hence the CVP should not be overly relied upon. Irrespective of
the cause, patients with shock are at risk of further complications
because of progressive tissue hypoxia, and ARDS, acute renal
failure and multi-organ failure may follow.
Management needs to be initiated early in patients with shock,
as mortality increases steadily with the duration of time that the
patient remains hypotensive. Management includes oxygen
therapy and assistance with ventilation to improve the hypoxaemia, appropriate fluid management, and inotropic and vasopressor drugs to maintain the circulation. It is important to identify
the underlying cause, as some aspects of management vary
depending on the cause. For example, patients with hypovolaemic
Shock
Shock is a broad term used to describe acute circulatory
collapse, with failure of adequate oxygen delivery to the tissues.
Presenting clinical features in all types of shock may include
hypotension, tachycardia (except in spinal shock), tachypnoea,
oliguria and confusion. The underlying causes of shock can be
grouped into one of five categories according to Table 5, and in
the obstetric population, the commonest causes are sepsis and
hypovolaemia following haemorrhage.
Pathophysiology
CO
SVR
Obstetric causes
Hypovolaemia
Distributive
Cardiogenic
Obstructive
Low
High, Low or normal
Low
Low
High
Low
High
High
Low or normal
Low
Neurogenic
Abbreviations: CO, cardiac output; SVR, systemic vascular resistance; DKA, diabetic ketoacidosis; PE, pulmonary embolism; IHD, ischaemic heart disease.
Table 5
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Sepsis in pregnancy
Worldwide, infection is still a significant cause of maternal
death, and there was a small increase in deaths due to genital
tract sepsis in the 2003e2005 Confidential Enquiry. Pregnant
women are more susceptible to certain infections due to
reduced cell-mediated immunity and raised corticosteroid
levels. The onset of life-threatening sepsis in pregnant women
can be insidious, with rapid clinical deterioration, and pyrexia
is not always present. One reason that the prognosis is still
more favorable than the non-obstetric population, is that the
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Pre-eclampsia
Possible crises of pre-eclampsia include the HELLP syndrome
(haemolysis, elevated liver enzymes and low platelets), pulmonary oedema, and eclampsia. The commonest causes of death are
intracranial haemorrhage and ARDS, and other maternal
complications include AKI, haemorrhage, DIC, and liver
dysfunction. Fetal complications include fetal growth restriction
(FGR), placental abruption, preterm delivery, and intrauterine
death. The key management points are control of hypertension
(methyldopa, nifedipine, labetalol, and/or hydralazine), treatment or prophylaxis of seizures (magnesium sulphate), careful
fluid administration to avoid pulmonary oedema, and decision
regarding delivery. Postnatal complications and postnatal onset
of pre-eclampsia may occur even following hospital discharge.
Cardiac disease
Around 1% of pregnant women have serious cardiac disease,
which may be congenital or acquired, and it remains the most
common cause of maternal mortality in the UK. Rheumatic mitral
stenosis is an increasing problem in the immigrant population.
Patients with pulmonary hypertension are at particularly high risk,
with maternal mortality of 25e40%, related to an inability to
tolerate the cardiovascular demands of late pregnancy and especially at delivery. Myocardial infarction secondary to ischaemic
heart disease is now the commonest cause of death, especially in
obese older women, and aortic dissection the next commonest.
Maternal complications include arrhythmias, cardiac failure,
thromboembolism and death. Risks to the fetus/neonate include
FGR, preterm delivery, respiratory distress syndrome, intraventricular haemorrhage, and death. It is crucial that women with
mechanical prosthetic valves remain adequately anti-coagulated.
Invasive procedures (such as valvuloplasty) and surgery are
usually avoided unless there is acute severe deterioration in status.
Cardiopulmonary bypass carries up to 30% fetal mortality, and
outcome is best if surgery is delayed until fetal viability, then the
fetus delivered by CS immediately before carrying out the surgery.
Peripartum cardiomyopathy
This is a cardiomyopathy specific to pregnancy, and defined as
the development of cardiac failure in the last month of pregnancy
or within 5 months of delivery, in the absence of both an identifiable cause and recognizable heart disease before this. The
aetiology is unknown, but risk factors include multiple pregnancy, multiparity, hypertension, pre-eclampsia, and prolonged
tocolysis. Outcomes differ between studies: 25e50% of women
recover, 7e14% require transplantation, with a maternal
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Table 6
Insulin therapy, to avoid hyperglycaemia and aim for appoximately 8 mmol/l, is probably optimal. Avoiding hyperglycaemia may reduce mortality, as well as decreasing
a number of other complications including prolonged
mechanical ventilation, neuropathy and need for renal
replacement therapy.
Recombinant Factor VII
Recombinant activated Factor VIIa (NovoSevenTM) although
unlicensed is used occasionally for intractable blood loss. It
induces short-term local haemostasis, and may buy time to
enable further correction of clotting times with standard blood
product support. It has been used for the treatment of obstetric
haemorrhage, with lifesaving results in some cases, but its use
remains controversial.
A
Corticosteroids in sepsis
Patients in septic shock often have relative adrenocortical
insufficiency (about 50%), and low-dose corticosteroid
replacement (<300 mg hydrocortisone/day) is frequently
used. Most trials have shown improved reversal of shock,
especially in those patients unresponsive to initial fluid
challenges and vasopressors, but large multicentre trials have
not shown a consistent clear reduction in mortality. Glucocorticoids are usually given in the form of intravenous
hydrocortisone (by infusion at 8 mg/hour or 6 hourly boluses
of 50 mg), and are quickly weaned when vasopressors are no
longer required.
FURTHER READING
Brace V, Kernaghan D, Penney G. Learning from adverse clinical outcomes:
major obstetric haemorrhage in Scotland, 2003e2005. BJOG 2007;
114(11): 1388e9.
Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign:
international guidelines for management of severe sepsis and septic
shock: 2008. Intensive Care Med 2008; 34: 17e60.
Farmer JC, Guntupalli KK, Baldisseri M, Gilstrap L. Critical illness of
pregnancy. Crit Care Med 2005; 33(Suppl.): S247e397.
James DK, Steer PJ, Weiner CP, Gonik B, eds. High-risk pregnancy. 3rd edn.
London: WB Saunders, 2005.
Leach R. Critical care medicine at a glance. Oxford: Blackwell Publishing
Ltd, 2004.
Lefkou E, Hunt B. Haematological management of obstetric haemorrhage.
Obstet Gynaecol Reprod Med 2008; 18(10): 265e27.
Lewis, G (ed) 2007. The Confidential Enquiry into Maternal and Child
Health (CEMACH). Saving Mothers Lives: reviewing maternal deaths to
make motherhood safer - 2003e2005. The Seventh Report on
Confidential Enquiries into Maternal Deaths in the United Kingdom.
London: CEMACH.
Nelson-Piercy C. Handbook of obstetric medicine. 3rd edn. London: Taylor
Francis, 2006.
Activated protein C
Recombinant human activated protein C, or drotrecogin alpha
(activated), has been shown to significantly reduce mortality in
severe sepsis and multiple organ failure, and is indicated in
those considered to be at high-risk of death. It has anti-inflammatory, antithrombotic, and profibrinolytic properties, and
a small increased risk of bleeding. There are a few published
case reports of its use in pregnancy in severe sepsis and acute
fatty liver.
Intensive insulin therapy
Insulin resistance and hyperglycaemia are common in critically
ill patients, even in those not previously known to be diabetic.
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Practice points
C
Research directions
C
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