Sodium Ferrous Citrate

sodium salt of ferrous 2-hydroxy -1,2-3-propanetricarboxylate

Content

Sodium Ferrous Citrate contains 10.011.0% of Fe (=55.85).

Description

Sodium Ferrous Citrate occurs as a green-white to greenish yellow

powder. It is odorless and has a weak iron taste.

Identification

(1)

To 5 ml of Sodium Ferrous Citrate solution (1 100), add 1

ml of diluted hydrochloric acid (1 4) and 0.5 ml of freshly prepared potassium

ferricyanide solution (1 10). A blue color develops.
(2)

To 5 ml of Sodium Ferrous Citrate solution (1 100), add 2 ml of aqueous

ammonia. A red-brown color develops, but no precipitate is formed.

(3)

Ignite 3 g of Sodium Ferrous Citrate at 500600 for 3 hours. The resulting

residue responds to all tests for Sodium Salt as described in the Qualitative Tests.
(4)

To 0.5 g of Sodium Ferrous Citrate, add 5 ml of water and 10 ml of potassium

hydroxide solution (1 25), heat in a water bath for 10 minutes while stirring well,
cool, and filter. Take a portion of the filtrate, neutralize with diluted acetic acid (1
2), add an excessive amount of calcium chloride solution (3 40), and boil. A white,
crystalline precipitate is formed. Collect the precipitate, and add sodium hydroxide
solution (1 25) to a part of it. The precipitate does not dissolve. Add diluted
hydrochloric acid (1 4) to the other part of the precipitate. It dissolves.
Purity

(1)

Sulfate

Not more than 0.48% as SO4.

Proceed as directed under Purity (2) for Ferric Citrate.

(2)

Ferric salt

Weigh 2.0 g of Sodium Ferrous Citrate, transfer into a flask with

a ground-glass stopper, dissolve in 5 ml of hydrochloric acid and 30 ml of water, add 4 g

of potassium iodide, stopper, and allow to stand in a dark place for 15 minutes. Add 2
ml of starch TS, and shake well. Even if a color develops, the color disappears on
addition of 1.0 ml of 0.1 mol/l sodium thiosulfate to the solution.
(3)

Heavy metals

Not more than 20 g/g as Pb.

Proceed as directed under Purity (4) for Ferric Citrate.

(4)

Arsenic

Not more than 4.0 g/g as As2O3.

Test Solution Weigh 1.0 g of Sodium Ferrous Citrate, add 10 ml of water, 1 ml of

sulfuric acid, and 10 ml of sulfurous acid, evaporate to about 2 ml, and add water to
make 10 ml. Use 5 ml of this solution as the test solution.

Apparatus Apparatus B.

Standard Color To 4.0 ml of Arsenic Standard Solution, add 10 ml of water, 1 ml

of sulfuric acid, and 10 ml of sulfurous acid. Proceed in the same manner as for the test
solution.
(5)

Tartrate

Weigh 1.0 g of Sodium Ferrous Citrate, add 5 ml of water and 10

ml of potassium hydroxide solution (1 15), heat in a water bath for 10 minutes

while stirring well, cool, and filter. Measure 5 ml of the filtrate, add diluted acetic acid
(1 4) to make it weakly acidic, then add 2 ml of acetic acid, and allow to stand for 24
hours. No white, crystalline precipitate is formed.
Assay

Weigh accurately about 1 g of Sodium Ferrous Citrate, transfer into a

flask with a ground-glass stopper, add 25 ml of diluted sulfuric acid (1 20) and 2 ml
of nitric acid, and boil for 10 minutes. After cooling, add 20 ml of water and 4 g of
potassium iodide, immediately stopper tightly, allow to stand in a dark place for 15
minutes, add 100 ml of water, and titrate the liberated iodine with 0.1 mol/l sodium
thiosulfate (indicator: starch TS). Perform a blank test in the same manner.
1 ml of 0.1 mol/l sodium thiosulfate = 5.585 mg of Fe