This gene encodes the most abundant protein in human blood. This protein
functions in the regulation of blood plasma colloid osmotic pressure and acts as
a carrier protein for a wide range of endogenous molecules including
hormones, fatty acids, and metabolites, as well as exogenous drugs.
Additionally, this protein exhibits an esterase-like activity with broad substrate
specificity. The encoded preproprotein is proteolytically processed to generate
the mature protein. A peptide derived from this protein, EPI-X4, is an
endogenous inhibitor of the CXCR4 chemokine receptor.
Este gen codifica la protena ms abundante en la sangre humana. Esta protena
funciona en la regulacin de coloide plasma sanguneo presin osmtica y acta como
una protena vehculo para una amplia gama de molculas endgenas incluyendo las
hormonas, cidos grasos, y metabolitos, as como las drogas exgenas. Adems, esta
protena exhibe una actividad esterasa-como con una amplia especificidad de sustrato.
La preprotena codificada se procesa proteolticamente para generar la protena
madura. Un pptido derivado de esta protena, EPI-X4, es un inhibidor endgeno de los
receptores de quimiocinas CXCR4.
The complete nucleotide sequence of human serum albumin mRNA has been
determined from recombinant cDNA clones and from a primer-extended cDNA
synthesis on the mRNA template. The sequence is composed of 2078
nucleotides, starting upstream from a potential ribosome binding site in the 5'
untranslated region. It contains all the translated codons and extends into the
poly(A) at the 3' terminus. Part of the translated sequence codes for a
hydrophobic prepeptide, Met-Lys-Trp-Val-Thr-Phe-Ile-Ser-Leu-Leu-Phe-Leu-PheSer-Ser-Ala-Tyr-Ser, followed by a basic propeptide, Arg-Gly-Val-Phe-Arg-Arg.
These signal peptides are absent from mature normal serum albumin and, so
far, have not been identified in their nascent state in humans. A remaining
1755 nucleotides of the translated mRNA sequence code for 585 amino acids,
which are in agreement, with few exceptions, with the published amino acid
sequence for human serum albumin. The mRNA sequence verifies and refines
the repeating homology in the triple-domain structure of the serum albumin
molecule.