Basic Medical Sciences Course for TCM Practitioners

General Pharmacology
Quiz 2
Name:

I/C No:

This quiz consists of ten (10) questions. Select one single best answer for every
question.
1. In pharmacodynamics, specificity of a receptor (key and lock model) means
A. A drug will only act against certain disease
B. A drug will only be effective in certain individuals
C. A drug will be more effective in a certain organ rather than another
D. A drug will only be potent in a particular dose range
2. In pharmacodynamics, saturability of a receptor means
A. A given dose will only exert its effects based on the number or available
receptors
B. A given dose will only distribute throughout the body in a given time
frame
C. A given dose will reach a plateau in plasma once excretion of the drug
begins
D. A given dose will not be metabolised unless it is bound to a receptor
3. If a drugs efficacy against a certain disease is 90%, the capacity of a drug to
activate the receptor and produce action is
A. 100%
B. 95%
C. 90%
D. 85%
4. The higher the dose required to produce a response,
A. the higher the potency
B. the lower the potency
C. the higher the sensitivity of the target tissue to the drug
D. the lower the affinity of the drug to the target receptor
5. The following type of drug antagonism will decrease both potency and efficacy
A. Partial competitive antagonism
B. Full competitive antagonism
C. Reversible antagonism
D. Irreversible antagonism

6. The following are pharmacokinetic drug interactions, EXCEPT

A.
B.
C.
D.
7. When
A.
B.
C.
D.

Altered GIT absorption

Displaced protein binding
Altered metabolism
Altered efficacy
a drug induces the enzyme responsible for the metabolism of drug A
The bioavailability of drug A will increase
The half-life of drug A will be shorter
The affinity of drug A for its receptor will decrease
Drug A will start to produce more toxic effects

8. The higher the therapeutic index of a drug,

A. the safer the drug
B. the lower the efficacy of the drug
C. the lower the potency of the drug
D. the higher the affinity of the drug for its receptor
9. The LD50 of a particular drug may be defined as
A. The dose at which 50% of a population may die as a result of being given
the drug
B. The dose at which 50% of patients show no improvement from taking the
drug
C. The dose at which 50% of toxic effects may appear after being given the
drug
D. The dose at which there is a 50% improvement in a patient after being
given the drug
10.The LD50 and ED50 of drug A is given as 90mg and 40mg, respectively. The LD 50
and ED50 of drug B is given as 120mg and 60mg, respectively. The following are
true, EXCEPT
A. The therapeutic index for drug A is 2.25
B. The therapeutic index for drug B is 2
C. Drug A is safer than drug B
D. 50% of patients given drug A will die if given a dose of 40mg