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IESAC

Efcacy

Indication

CEFTRIAXONE1GM
IVPDR.FORINJ

ProteinBinding:
83%to96%

Distribution
Prostatetissue,0.6to
50mcg/g:
Ceftriaxone
concentrations4
hoursaftera2gram
IVdosewere1to50
mcg/gandwere0.6to
5.6mcg/gat48hours

Safety

E.coli
52.8%

ADR
Common
Indurationatinjectionsite,Warmth,
tightness,orindurationDiarrhea
EosinophiliaThrombocytosis
Serious
Erythemamultiforme,
StevensJohnsonsyndrome,Toxic
epidermalnecrolysis
Pseudomembranousenterocolitis
Hemolyticanemia
Hypersensitivityreaction,Renal
failure,Injuryoflung

Adherence
Admin Regimen
IV

QD

Cost

16.00
/vial
(

1course

(2

/14)
224

Efcacy

Indication

CIPROFLOXACIN
400MG/200ML
SOL.FORINJ.

ProteinBinding:
20%to40%

DistributionProstatic
tissue,excellent:
Ciprofloxacin
achieveshigh
concentrationsin
prostatictissue,with
tissuelevelsbeing
approximatelytwice
ashighas
correspondingserum
concentrations

Safety

E.coli
37.6

ADR
Common
Rash(upto1.8%)
Diarrhea(1.6%to4.8%),Nausea
(2.5%to4%),Vomiting(1%to
4.8%)
Headache(oralextendedrelease
tablets,3%IV,greaterthan1%)
Irritability(5%)
Nasaldischarge(3%),
Nasopharyngitis(5%)
Serious
Aorticaneurysm,Ordissection,
Cardiorespiratoryarrest(upto1%),
Myocardialinfarction(upto1%),
ProlongedQTinterval,Syncope(up
to1%),Torsadesdepointes
Photosensitivity(upto1%),
StevensJohnsonsyndrome(upto
1%),Toxicepidermalnecrolysis
(upto1%)

Adherence
Admin Regimen
IV

BID

Cost

106.47
/200ml
(

1course

(2

/14)
2981.16

Clostridiumdifficilediarrhea(upto
1%),Gastrointestinalhemorrhage
(upto1%),Pancreatitis(upto1%
),Pseudomembranousenterocolitis
Agranulocytosis,Aplasticanemia,
Bonemarrowdepression,
Hemolyticanemia,Leukopenia
(0.4%),Pancytopenia(0.1%),
Thrombocytopenia
Hepaticnecrosis(upto1%),
Hepatitis(upto1%),
Hepatotoxicity,Liverfailure
Hypersensitivityreaction(upto1%
)
Myastheniagravis,Exacerbation,
Ruptureoftendon,Tendinitis
Raisedintracranialpressure,
Seizure(upto1%)
Retinaldetachment
Depression(upto1%),Psychotic
disorder(upto1%)
Acuterenalfailure(upto1%),
Hemorrhagiccystitis(upto1%)

Efcacy

Indication

GENTAMICIN80
MG/2MLSOL.FOR
INJ.

ProteinBinding:
Low,0%to30%

Distribution
Urogenitaltissue:
good:Gentamicin
concentrationsmay
reachupto8times
higherintherenal
cortexcomparedwith
usualserumlevels.
Urineconcentrations
above100mcg/mL
maybeachieved

Safety

E.coli
63.1

ADR
Serious
Neuromuscularblockade
finding,Ototoxicity,Nephrotoxicity,
Respiratorytractparalysis,
Concomitantanesthesia,muscle

relaxants

Adherence
Admin Regimen
IV

Cost

5mg/kg 5.35
qd
(

1course

(2

/14)

Indication

AMIKACIN500MG
SOL.FORINJ.

Efcacy

ProteinBinding:
4%to11%

Absorption
INTRAVENOUS24
hours

Safety

E.coli
97.1

Adherence

ADR

Admin Regimen

Serious
Neuromuscularblockade
finding,Ototoxicit,Nephrotoxicity,

Respiratorytractparalysis,

IV

Cost

32.10
15mg/kg (

qd

1course

(2

/14)