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Diabetes Mellitus Type 2

Diabetes Type 2

Insulin Resistance
Hyperglycemia

Blood
Osmolality

Fluid shifting
from
intracellular
to
extracellular
Intracellular
DHN

Thirst
Sensation

Blood
viscosity

Blood
Flow

Tissue
Perfusion

Blood sugar exceeds


renal threshold

Favors
bacterial
growth

Infection

Wound
Healing

Glucose cannot
enter cell

Glycosuria

Cellular
Starvation

Osmotic
Diuresis

Sensation
of hunger

Urine
Output

Polyphagia

Polyuria

Gluconeogenesis
activation

Lipolysis

CHON breakdown

Accumulation
of by product

Muscle Wasting and poor


wound healing

Fatty
Acids

Atherosclerosis

Polydipsia
Gangrene
Formation

Amputation

Ketones

Toxic to Brain tissue

Acetone
Breath

Metabolic
acidosis
Ketonuria

Micropathy
Macropathy

Diabetic
Ketoacidosis
CVA, MI, PVD

Neuropathy
Loss of Sensation
Tingling/numbness
Weakness

Retinopathy

Nephropathy

Loss of vision
Blindness

ESRD