epithelial tumors in
different organs.
Epithelial tumors
ectoderm -skin
mesoderm-kidney
endoderm - GIT
Structure
the parenchyma
Benign
malignant
non-neoplastic stroma
Epithelial tumors
Benign
Papilloma
Gastro-intestinal tract
Malignant
Skin
Epithelial lining of glands
and ducts
Adenoma
Respiratory passages
carcinomas
Endocrine glands
Benign
Malignant
Papillomas
Exophytic lesions
Rarely endophytic lesions
Inverted papilloma
Histology
Papillae
Epithelium lining
Preserved basement
membrane
Connective tissue core
Verrucae
skin
viruses
esophagus
larynx
precancerosis
Condylomata
genitals, anus
condyloma acuminatum
condyloma lata
syphilis
Urothelial papillomas
Transitional epithelium of
ureter, bladder, uretra
Precancerosis
Histology
Fragile papillae
Urine -cytology
Adenomas
Glandular epithelium
Endocrine glands
Exocrine glands
Breast
Exocrine pancreas
Gastrointestinal tracts
Respiratory tract
Ovarium
Liver
Kidney
Adenomas
Macroscopy
nodules, capsulated
Mucosa surface
pedunculated and sessile
polyps
Single, multiple
Gardners syndrome - +
osteomas, fibromas
Various size
< 1 cm
> 3 cm
Adenomas
Histology
Glands
low-grade or high-grade
high grade often
classified with
carcinoma-in-situ
may develop into malignancy
Uterine cervix
Colon polyps
Dysplasia
Normal gland
Moderate dysplasia
Mild dysplasia
Moderate dysplasia
Severe dysplasia
Adenomas
Histological types
acinar
trabecular
tubule, GIT
Papillae, GIT
tubulovilous, GIT
Nests, bronchi
tubular
Villous
Mixed
Solid
Cystic
fibroadenoma
breast
Tumor mixtus
Capsulated,
mucinous cut surface
Histology
Gland structures
Myoepithelial cells
Mucoid substance
Basophilic
Resemble
cartilagous
parenchyma
Gland structures
Loose connective tissue
pericanalicular
Intracanalicular
Fibrous stroma
Ovarian cystadenoma
= Carcinomas
Risk factors
Macroscopy
Histology
Metastases
Lymph nodes
Distant metastases
Seeding
TNM staging
Carcinomas
Carcinomas
Adenocarcinoma
Hepatocellular carcinoma
Renal cell carcinoma
Seminoma
Choricarcinoma
skin
Face
Oral cavity
leukoplakia
Esophagus
Larynx
Bronchus
Metaplasia of stratified
squamous non-ketatinized
epithelium into keratinized
Histology
Keratinization
perls
High differentiation
With keratinization
Moderate differentiation
keratinization
Low differentiation
Without keratinization
= carcinoma planocellulare non-keratodes
WELL?
MODERATE?
POOR?
Grading for Squamous Cell Carcinoma
=Ulcus rodens
Tumor cells resemble the normal epidermal basal cell layer from
which they are derived
2 patterns: superficial type or nodular lesions
= Adenocarcinoma
Breast
Salivary glands
Gastro-intestinal tract
Pancreas
Endocrine glands
Female genital system
endometrium
ovarium
testis - seminoma
Adenocarcinomas
Histology
Gland structures
Various shape
cellular atypia
invasion through tissue
layers
basement membranes
muscularis mucosae
Adenocarcinomas
Histological types
Mucinous
Mucin production
Intra-, extracellular
"signet-ring" cells
Papillary carcinoma
Cystadenocarcinoma
Adenoacantoma
Adenosquamous carcinoma
Mucoepidermoid carcinoma
Mucinous adenosquamous
carcinoma
Adenocarcinoma ventriculi
Intestinal type
Diffuse type
Adenocarcinoma uteri
Seminoma Testis
Choriocarcinoma
Hepatocellular carcinoma
Undifferentiated
carcinomas
2 types
Scirousum
stroma firm
breast
medullare
stroma - soft