Topic:Lipids (Topics 6)

1. The synthesis of 3-hydroxy-3-methyl-glutaryl-CoA can occur:

(A)
Only in mitochondria of all mammalian tissues
(B)
Only in the cytosol of all mammalian tissue
(C)
In both cytosol and mitochondria
(D)
In lysosomes
2. In humans under normal conditions loss of ketone bodies via urine is usually less
than
(A)
1 mg/24 hr
(B)
4 mg/24 hr
(C)
8 mg/24 hr
(D)
10 mg/24 hr
3. The calorific value of lipid is
(A)
4.0 Kcal/gm
(B)
6.0 Kcal/gm
(C)
9.0 Kcal/gm
(D)
15 Kcal/gm
4.The
(A)
(B)
(C)
(D)

major lipid in chylomicrons is

Triglycerides
Phospholipids
Cholesterol
Free fatty acids

5. Number of carbon atoms in cholesterol is

(A)
17
(B)
19
(C)
27
(D)
30
6. Which of the following is a polyunsaturated fatty acid?
(A)
Palmitic acid
(B)
Palmitoleic acid
(C)
Linoleic acid
(D)
Oleic acid
7. HDL is synthesized in
(A)
Adipose tissue
(B)
Liver
(C)
Intestine
(D)
Liver and intestine
8. Which of the following has the highest cholesterol content?
(A)
Meat
(B)
Fish
(C)
Butter
(D)
Milk

9. Arachidonic acid contains the number of double bonds:

(A)
2
(B)
3
(C)
4
(D)
5
10. Phrynoderma is a deficiency of
(A)
Essential fatty acids
(B)
Proteins
(C)
Amino acids
(D)
None of these
11. Atherosclerosis and coronary heart diseases are associated with the diet:
(A)
High in total fat and saturated fat
(B)
Low in protein
(C)
High in protein
(D)
High in carbohydrate
12. The importance of phospholipids as constituent of cell membrane is because
they possess
(A)
Fatty acids
(B)
Both polar and no-polar groups
(C)
Glycerol
(D)
Phosphoric acid
13.
(A)
(B)
(C)
(D)

Long chain fatty acids penetrate the inner mitochondrial membrane

Freely
As acyl-CoA derivative
As carnitine derivative
Requiring Na+ dependent carrier

14. Glycosphingolipids are a combination of

(A)Ceramide with one or more sugar residues

(B) Glycerol with galactose
(C) Sphingosine with galactose
(D) Sphingosine with phosphoric acid
15. The importance of phospholipids as constituent of cell membrane is because
they possess
(A) Fatty acids
(B) Both polar and nonpolar groups
(C) Glycerol
(D) Phosphoric acid
16. Deterioration of food (rancidity) is due to presence of
(A) Cholesterol
(B) Vitamin E
(C) Peroxidation of lipids
(D) Phenolic compounds
17. Molecular formula of cholesterol is
(A) C27H45OH
(B) C29H47OH
(C) C29H47OH
(D) C23H41OH
18. Dietary fats after absorption appear in the circulation as
(A) HDL
(B) VLDL
(C) LDL
(D) Chylomicron
19. Free fatty acids are transported in the blood
(A) Combined with albumin
(B) Combined with fatty acid binding protein
(C) Combined with -lipoprotein
(D) In unbound free salts
20. The enzymes of -oxidation are found in
(A) Mitochondria
(B) Cytosol
(C) Golgi apparatus
(D) Nucleus

21. The lipoprotein richest in cholesterol is

(A) Chylomicrons
(B) VLDL

(C) LDL
(D) HDL
22. Which of the following is omega-3 polyunsaturated fatty acid?
(A) Linoleic acid
(B) -Linolenic acid
(C) -Linolenic acid
(D) Arachidonic acid
23. Which one of the following Acyl Carrier Protein contains the vitamin?
(A) Biotin
(B) Lipoic acid
(C) Pantothenic acid
(D) Folic acid
24. All the following have 18 carbon atoms except
(A) Linoleic acid
(B) Linolenic acid
(C) Arachidonic acid
(D) Stearic acid
25. Triglycerides are transported from liver to extrahepatic tissues by
(A) Chylomicrons
(B) VLDL
(C) HDL
(D) All of these
26. Cholesterol is transported from liver to extrahepatic tissues by
(A) Chylomicrons
(B) VLDL
(C) HDL
(D) LDL
27. -Oxidation of fatty acids requires all the following coenzymes except
(A) CoA
(B) FAD
(C) NAD
(D) NADP
28. Which of the following can be oxidized by -oxidation pathway?
(A) Saturated fatty acids
(B) Monosaturated fatty acids
(C) Polyunsaturated fatty acids
(D) All of these
29. Carnitine is required for the transport of

(A) Triglycerides out of liver

(B) Triglycerides into mitochondria
(C) Short chain fatty acids into mitochondria
(D) Long chain fatty acids into mitochondria

30. How many carbon atoms are removed during each cycle of -oxidation proper?
(A) One carbon atom is removed from the carboxyl end of the fatty acid
(B) One carbon atom is removed from the methyl end of the fatty acid
(C) Two carbon atoms are removed from the carboxyl end of the fatty acid
(D) Two carbon atoms are removed from the methyl end of the fatty acid

31. How many ATPs net generated during oxidation of palmitic acid?
(A) 129 ATP equivalents
(B) 131 ATP equivalents
(C) 146 ATP equivalents
(D) 148 ATP equivalents

32. Acetyl CoA formed from pyruvate can be used for the synthesis of all the
following except
(A) Glucose
(B) Fatty acids
(C) Cholesterol
(D) Steroid hormones

33. Hypocholesterolaemia can occur in patients suffering from following.

(A) Hyperthyroidism

(B) Nephrotic syndrome

(C) Obstructive jaundice
(D) Diabetes mellitus

34. Bile pigments are present and urobilinogen absent in urine in.
(A) Haemolytic jaundice
(B) Hepatocellular jaundice
(C) Obstructive jaundice
(D) Crigler-Najjar syndrome

35. Bile pigments are absent and urobilinogen increased in urine in

(A) Haemolytic jaundice
(B) Hepatocellular jaundice
(C) Obstructive jaundice
(D) Rotors syndrome

36. A test to evaluate detoxifying function of liver is

(A) Serum albumin: globulin ratio
(B) Galactose tolerance test
(C) Hippuric acid test
(D) Prothrombin time

37. Which of the following are classified as essential fatty acids?

(A) Arachidonic acid
(B) Oleic acid

(C) Acetic acid

(D) Butyric acid
38. Cholesterol is the precursor for the biosynthesis of
(A) fatty acid
(B) prostaglandins
(C) bile acids
(D) sphingmyelin