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# Perhitungan dosis

Daun Randu =

10 gram direbus
3 gelas = 200 mg (1 gelas) 10 gram/200 ml
Uapkan sampai 38,5 ml

Dosis empiris = 10 gram


Dosis 1 =1/2 x 0.026 gram = 0.013 gram/20 gram BB mencit
Dosis 2 = 0.026 gram /20 gram BB mencit
Dosis 3 = 2 x 0,026 gram = 0.052 gram/20 gram BB mencit
Diambil Dosis 3 = 0.052 gram/0.2 ml
100/2 x 0.052 = 26 gram.
26 gram/ 100 ml
0,052/10 x 200 ml = 1.04 ml
0.52X = 0.2
X=38.5 ml
# Tablet loperamid dipasaran 2mg x 2 = 4 mg.
Konversi ke mencit : 4 mg x 0.0026 = 0.0104 mg /20 gram BB mencit
Berat tablet yang diambil : 0.0104/2 mg x 100 mg = 0.52 mg/0.2 ml
Dibuat larutan 50 ml = 0.52 mg/0.2 mg x 50 ml = 130 mg/ 50 ml
# PGA 1%
1/100 x 100 = 1 gram/100 ml.

Tests of Normality
Kolmogorov-Smirnova

kelompok

Statistic

data

df

Shapiro-Wilk

Sig.

Statistic

df

Sig.

kontrolnegatif

.333

.828

.163

kontrolpositif

.367

.729

.024

dosis 1

.251

.927

.574

dosis 2

.332

.853

.235

dosis 3

.262

.895

.408

a. Lilliefors Significance Correction


HO = data berdistribusi normal
H1 = data tidakberditribusi normal
H0 = ditarikjika sig > (o,05)

Kontrol (-) sig = 0,163> 0,05

95%
100% - 95 % = 5%
H0 diterima /data berdistribusi normal

Test of Homogeneity of Variances


Data
Levene Statistic

df1

.216

df2
4

Sig.
15

.926

H0 = Data Homogen
H1 = Data tidak homogeny
H0 jikaditarik sig > (0,05) 95%
Sig = 0,926 > 0,05

100 95% = 5%

H0 diterima / data homogen.


ANOVA

data
Sum of Squares

df

Mean Square

Between Groups

280.300

70.075

Within Groups

228.500

15

15.233

Total

508.800

19

Sig.

4.600

H0 = data 5 perlakuan tidak berbeda signifikan.


H1 = data 5 perlakuan berbeda signifikan
H0 jika ditarik sig > (0,05)
Sig = 0,13< 0.05

95%

100 95% = 5%

H1 diterima /data 5 perlakuan berbeda signifikan.

.013

Multiple Comparisons
Dependent Variable: data
LSD
(I) kelompok

(J) kelompok

Mean Difference

Std. Error

Sig.

(I-J)

dosis 1

dosis 2

dosis 3

.001

4.87

16.63

dosis 1

7.250*

2.760

.019

1.37

13.13

dosis 2

8.750*

2.760

.006

2.87

14.63

dosis 3

9.000*

2.760

.005

3.12

14.88

-10.750*

2.760

.001

-16.63

-4.87

dosis 1

-3.500

2.760

.224

-9.38

2.38

dosis 2

-2.000

2.760

.480

-7.88

3.88

dosis 3

-1.750

2.760

.536

-7.63

4.13

kontrolnegatif

-7.250*

2.760

.019

-13.13

-1.37

kontrolpositif

3.500

2.760

.224

-2.38

9.38

dosis 2

1.500

2.760

.595

-4.38

7.38

dosis 3

1.750

2.760

.536

-4.13

7.63

kontrolnegatif

-8.750*

2.760

.006

-14.63

-2.87

kontrolpositif

2.000

2.760

.480

-3.88

7.88

dosis 1

-1.500

2.760

.595

-7.38

4.38

dosis 3

.250

2.760

.929

-5.63

6.13

kontrolnegatif

-9.000*

2.760

.005

-14.88

-3.12

kontrolpositif

1.750

2.760

.536

-4.13

7.63

dosis 1

-1.750

2.760

.536

-7.63

4.13

dosis 2

-.250

2.760

.929

-6.13

5.63

*. The mean difference is significant at the 0.05 level.

Ket :

Upper Bound

2.760

kontrolnegatif
kontrolpositif

Lower Bound

10.750*

kontrolpositif
kontrolnegatif

95% Confidence Interval

= berbeda signifikan Artinya obat berkhasiat