INTRAVENA

HASIL DISKUSI INTRAVENA

A. INTRAVENA
Data Intravena
t (Jam)
3
4
6
8
12
24

Cp (g/mL)
62,98
52,32
36,08
24,88
11,83
1,27

Log Cp (g/mL)
1,799
1,718
1,557
1,395
1,072
0,103

1. Menentukan orde reaksi

Orde 0 (t vs cp):

Orde 1 (t vs log cp):

a = 56,999
b = -2,677
r = -0,883
2. Tetapan Laju Eliminasi (K)
K = -b . 2,3
= -(-0,080) . 2,3
= 0,184 Jam-1
3. Waktu Paruh (t 1/2)
t 1/2 = 0,693
K
= 0,693
0,092
= 3,766 Jam

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150 2012 0109

a = 2,041
b = -0,080
r = -0,999 (mengikuti orde 1)

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INTRAVENA
4. Volume Distribusi (VD)
Diketahui :
Fraksi intravena : 1
Dosis obat
: 100 mg (100.000 g)
VD
= F x Do
Cp
= 1 x 100.000
109,900
= 909,918 mL
5. Area Under Curve (AUC)
1 [ AUC ]tntn1=

[ AUC ]3 =

Cp n+Cp n 1
(t nt n1)
2

52,32+62,96
( 43 )
2
115,3
( 1)
2

57,65 g . Jam/mL
6

[ AUC ]4 =

36,08+ 52,32
( 64 )
2
88,4
(2)
2

88,4 g . Jam/ mL

[ AUC ]86=

24,88+36,08
( 86 )
2
60,96
(2)
2

60,96 g . Jam/mL

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150 2012 0109

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INTRAVENA
[ AUC ]12
8 =

11,83+24,88
(128 )
2

36,71
(4 )
2

73,42 g . Jam/mL
[ AUC ]24
12 =

1,27+11,83
( 2412 )=70,9
2

13,1
(12 )
2
78,6 g . Jam/mL

AUC=57,65+88,4 +60,96+73,42+78,6
359,03 g . Jam /mL

2 [ AUC ]ttn =

Cpn
K
1,27
0,184
6,902 g . Jam/mL

3 [ AUC ] =

F Do
VD K

1 100.000
909,918 x 0,184

100.000
167,424

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150 2012 0109

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INTRAVENA
597,285 g . Jam/mL
t

4 [ AUC ] ekstrapolasi=

[ AUC ] tn
AUC

100

6,902
100
359,03

1,922
DAFTAR PUSTAKA
Shargel, L. & Andrew B.C.YU. 2012. Biofarmasetika Farmakokinetik dan
Terapan. Airlangga University Press: Surabaya.

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150 2012 0109

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