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Home A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TIROFIBAN HYDROCHLORIDE IN PURE AND MARKETED FORMULATION
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Ayurvedic Method
HPLC Method
About Authors:
Sukanto Paul, Krishan R Bhadu
Department of Quality Assurance, School of Pharmaceutical Sciences,
Jaipur National University,
Jagatpura, Jaipur-302025,
Rajasthan, India.
ABSTRACT
A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Tirofiban
hydrochloride in pure and marketed formulation. Chromatography was carried out on a BDS Hypersil C18 (4.6 mm 250 mm, 5 m) using Buffer:
Acetonitrile in the ratio of 80:20 (v/v) as the mobile phase at a flow rate of 1.5 mL/min and eluents were monitored at 274 nm using UV detector at
ambient temperature. The average retention time of Tirofiban was found to be 9.124 min. The method was validated for linearity, precision, accuracy,
specificity, robustness and solution stability. The calibration curve was linear (R 20.9999) over the range of 12.5-75 g/mL.Limit of detection (LOD) and
Limit of quantitation (LOQ) were 0.11 g/mL and 0.33 g/mL respectively. This method can be successfully employed for the quantitative analysis of
Tirofiban hydrochloride in bulk drugs and formulations.
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